Effects of ventilation with 100% oxygen during early hyperdynamic porcine fecal peritonitis*

Abstract

During early hyperdynamic porcine septic shock, 100% oxygen improved organ function and attenuated tissue apoptosis without affecting lung function and oxidative or nitrosative stress. Therefore, it might be considered as an additional measure in the first phase of early goal-directed therapy.

DNA damage after long-term repetitive hyperbaric oxygen exposure

“…EXPOSURE TO HYPERBARIC OXYGEN (HBO), i.e., pure oxygen breathing at supra-atmospheric pressures, increases the formation of oxygen radical species (21,27), which in turn results in consumption of antioxidants (2,23) and reduces antioxidant enzyme activity (4), ultimately causing lipid peroxidation (3,4,26,31), organ injury (5), and DNA damage (10, 11, 17, 20, 26, 32-37, 39 -42). On the other hand, HBO was reported to promote protective preconditioning against ischemia-reperfusion-induced oxidative organ injury in the brain, spinal cord, heart, and liver (16,28,45,46).…”

Adaptation of the NDIR technology to13CO2breath tests under increased inspiratory O2concentrations

“…The experiments were performed in the frame of a hyperoxia study (1), in adherence to the National Institutes of Health Guidelines on the Use of Laboratory Animals. The study protocol was approved by the University Animal Care Committee and the Federal Authorities for Animal Research (Regierungspräsidium Tübingen, Germany).…”

“…After induction of fecal peritonitis, 20 anesthetized and instrumented domestic pigs of either sex were ventilated, with either 100% oxygen, or oxygen as needed to maintain arterial hemoglobin saturation Ͼ90%. Throughout the experimental phase of 24 h, the pigs received glucose to keep glycemia in the range of 4 -6 mmol/l and a constant infusion of [1,2,3,4,5,[6][7][8][9][10][11][12][13] C6]glucose at a rate of ϳ3 mg ⅐ kg Ϫ1 ⅐ h Ϫ1 . Breath gas and blood samples were taken for ϳ25 different time points.…”

Efeito da ressuscitação tardia na gravidade da sepse, na intensidade do tratamento e na função mitocondrial em um modelo experimental de peritonite fecal

“…Examples include studies with brief exposure to peritonitis (25)(26)(27), those starting supportive care immediately after peritonitis induction (24,(28)(29)(30)(31)(32), and variable use of catecholamines (28,30,33). With the exception of needing to maintain anesthesia while peritonitis developed, we attempted to reproduce the typical clinical scenario of sepsis in this experimental model.…”

“…Experimental sepsis research has largely focused on acute models (24)(25)(26)(27)(28)(29)(30)(31)(32)(33), whereas clinical sepsis typically develops over hours or days (8). Furthermore, in the clinical setting, timing of resuscitation seems to have an important impact on systemic, organ-specific, and cellular effects of sepsis.…”