Effects of vancomycin linoleic acid nanoparticles on male reproductive indices of Sprague–Dawley rats

Abstract

The management of bacterial infections, especially trains of methicillin-resistant Staphylococcus aureus observe in health care settings, has markedly improved with the introduction of established drugs but using newer nano-based formulations. This study investigates the effects of vancomycin-linoleic acid nanoparticles on testicular tissue in an experimental animal model. Twenty-five adult male Sprague-Dawley rats maintained at the Animal House of the Biomedical Resources Unit were assigned to five groups namely Esolid lipid nanoparticles; Fvancomycin solid lipid nanoparticle; Glinoleic acid nanoparticle; Hvancomycin linoleic acid; and Acontrol. Perturbations in seminal fluid parameters showed a reduced sperm count in groups F & G which was statistically significant (p < .05) but motility and morphology were not significant when compared to controls (A). Reduced testosterone levels were found in groups E, F and H but were not statistically significant (p > .05). There was also increased luteinizing hormone (LH) and decreased in follicular stimulating hormone (FSH) levels was statistically significant (p < .05). Hypoplasia, tubular atrophy and shrinkage were observed in histologic sections of the treated groups with basement membrane thickening. Vancomycin solid lipid nanoparticle and its constituents SLN and LA disrupted testicular morphometry and the hormonal milieu sufficient to potentially induce altered reproductive function.

Effect of COVID‐19 vaccination on semen parameters: A systematic review and meta‐analysis

“… 28 However, these nanoparticles may cross the biological barriers to deposit in reproductive organs including testis, and thus impair semen quality by increasing inflammation, disrupting DNA structure, decreasing mitochondrial function, and promoting reactive oxygen species production and apoptosis. 39 , 40 , 41 To address this issue, Olana et al 18 analyzed the reactive oxygen metabolites, electrolytes, and interleukin‐6 in seminal plasma, but found no significant differences between the pre‐ and postvaccination stages of BNT162b2. Therefore, these seemingly rational claims had little or no scientific evidence from basic research, and were not supported by our pooled analysis of clinical data as well.…”

“…For example, both mRNA‐1273 and BNT162b2 are lipid nanoparticle‐formulated vaccines for COVID‐19 28 . However, these nanoparticles may cross the biological barriers to deposit in reproductive organs including testis, and thus impair semen quality by increasing inflammation, disrupting DNA structure, decreasing mitochondrial function, and promoting reactive oxygen species production and apoptosis 39–41 . To address this issue, Olana et al 18 analyzed the reactive oxygen metabolites, electrolytes, and interleukin‐6 in seminal plasma, but found no significant differences between the pre‐ and postvaccination stages of BNT162b2.…”

“…For example, both mRNA-1273 and oxygen species production and apoptosis. [39][40][41] To address this issue, Olana et al 18 analyzed the reactive oxygen metabolites, electrolytes, and interleukin-6 in seminal plasma, but found no significant differences between the pre-and postvaccination stages of BNT162b2. Therefore, these seemingly rational claims had little or no scientific evidence from basic research, and were not supported by our pooled analysis of clinical data as well.…”

Resveratrol Ameliorates Vancomycin-Induced Testicular Dysfunction in Male Rats

“…Several recent studies have reported that vancomycin may adversely affect the testes and cause apoptosis in some cases. [ 16 , 17 ]. It is still unclear how vancomycin causes testicular toxicity.…”