Effects of Urginea sanguinea, a traditional asthma remedy, on embryo neuronal development

Marx, Jean L.; Pretorius, Etheresia; Bester, Megan Jean

doi:10.1016/j.jep.2005.09.022

Cited by 12 publications

(13 citation statements)

References 33 publications

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“…The mesencephalon was used because the midbrain develops from this area and many ERs are found here (Kuiper et al, 1998). Also, Marx et al (2006), Pretorius et al (in press), and da Silva et al (in press) found that the mesencephalon is easily distinguishable when dissecting the brain; therefore for consistency in dissecting this area was chosen. The tissue was covered with 2.5% glutaraldehyde (in 0.075 M NaPO 4 buffer and 2 mM MgCl 2 added, pH ¼ 7.4).…”

Section: Animals and Treatmentsmentioning

confidence: 99%

“…The developmental events characterized by discrete transitions in morphological development of the chicken embryo have been well established (Rogers, 1996) and is welldepicted by the Carnegie Stages (Butler and Juurlink, 1987). Marx et al (2006) adapted the methodology of the chicken in ovo model to use the material for scanning (SEM) and transmission electron microscopy (TEM). For a detailed discussion of the model, see Marx et al (2006).…”

Section: The Chicken Prenatal In Ovo Modelmentioning

confidence: 99%

“…Marx et al (2006) adapted the methodology of the chicken in ovo model to use the material for scanning (SEM) and transmission electron microscopy (TEM). For a detailed discussion of the model, see Marx et al (2006).…”

Section: The Chicken Prenatal In Ovo Modelmentioning

confidence: 99%

“…Embryonic tissue is characterized by rapid growth, is highly sensitive to toxic and teratogenic effects, and is therefore ideal for testing the cytotoxic effects of drugs. The chicken prenatal in ovo model provides a relatively easy way in which the embryonic endocrine environment can be influenced without confounding maternal influences (Jenkins and Porter, 2004;Marx et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…(a) represents a typical unexposed 8-day-old chicken neurons viewed by the SEM (Â3700) (fromMarx et al, 2006; reproduced with permission courtesy of Elsevier).…”

mentioning

confidence: 99%

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Ultrastructural effects of DDT, DDD, and DDE on neural cells of the chicken embryo model

Bornman¹,

Pretorius²,

Marx³

et al. 2007

Environmental Toxicology

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Human exposure to environmental compounds with estrogenic activity and the potential effects on human health is the subject of ongoing scientific debates. Their potential effects raise concern regarding neurological development after prenatal exposure. Central to this debate is the pesticide 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT). Although it has apparent low acute toxicity in mammals, DDT has a long residual persistence and laboratory research has indicated that it acts on the CNS by interfering with Na(+)/K(+) pump mechanism of the neuronal membranes, causing disruption in Ca(2+) homeostasis. Potentially this may lead to both apoptosis and necrosis. The present study investigates the effects of DDT and two of its metabolites DDD and DDE on the ultramorphology of neural cells, using a previously published chicken embryo model. Results indicate cellular swelling, budding, and increased membrane permeability for all three chemicals, accompanied by karyolysis in the DDE group (typical features of oncosis). These results support the finding of other researchers as well as the concerns of the WHO that DDT and its metabolites may cause neurotoxicity after prenatal exposure.

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Section: Animals and Treatmentsmentioning

confidence: 99%

Section: The Chicken Prenatal In Ovo Modelmentioning

confidence: 99%

Section: The Chicken Prenatal In Ovo Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…(a) represents a typical unexposed 8-day-old chicken neurons viewed by the SEM (Â3700) (fromMarx et al, 2006; reproduced with permission courtesy of Elsevier).…”

mentioning

confidence: 99%

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Ultrastructural effects of DDT, DDD, and DDE on neural cells of the chicken embryo model

Bornman¹,

Pretorius²,

Marx³

et al. 2007

Environmental Toxicology

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Necroptosis: a potential, promising target and switch in acute pancreatitis

Wang

et al. 2015

Apoptosis

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Pancreatic acinar cell death is the major pathophysiological change in early acute pancreatitis (AP), and the death modalities are important factors determining its progression and prognosis. During AP, acinar cells undergo two major modes of death, including necrosis and apoptosis. Acinar necrosis can lead to intensely local and systemic inflammatory responses, which both induce and aggravate the lesion. Necrosis has long been considered an unregulated, and passive cell death process. Since the effective interventions of necrosis are difficult to perform, its relevant studies have not received adequate attention. Necroptosis is a newly discovered cell death modality characterized by both necrosis and apoptosis, i.e., it is actively regulated by special genes, while has the typical morphological features of necrosis. Currently, necroptosis is gradually becoming an important topic in the fields of inflammatory diseases. The preliminary results from necroptosis in AP have confirmed the existence of acinar cell necroptosis, which may be a potential target for effectively regulating inflammatory injuries and improving its outcomes; however, the functional changes and mechanisms of necroptosis still require further investigation. This article reviewed the progress of necroptosis in AP to provide a reference for deeply understanding the pathogenic mechanisms of AP and identifying new therapeutic targets.

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Effects of Rhodocodon madagascariensis extracts on embryo–larval development of medaka fish, Oryzias latipes

Rakotobe¹,

Berkal²,

Huet³

et al. 2009

Food and Chemical Toxicology

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Effects of Urginea sanguinea, a traditional asthma remedy, on embryo neuronal development

Cited by 12 publications

References 33 publications

Ultrastructural effects of DDT, DDD, and DDE on neural cells of the chicken embryo model

Ultrastructural effects of DDT, DDD, and DDE on neural cells of the chicken embryo model

Necroptosis: a potential, promising target and switch in acute pancreatitis

Effects of Rhodocodon madagascariensis extracts on embryo–larval development of medaka fish, Oryzias latipes

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