Effects of urban particulate matter on the quality of erythrocytes

Tian, Yaxian; Li, Yuxuan; Sun, Shuli; Dong, Yanrong; Tian, Zhaoju; Zhan, Linsheng; Wang, Xiaohui

doi:10.1016/j.chemosphere.2022.137560

Cited by 6 publications

(2 citation statements)

References 55 publications

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“…A similar study in the Mexico–US border region reflected the same consistency in an increasing trend in the RBC hemolysis rate and PM 2.5 concentrations [ 37 ]. Similar results have been reported in an in vivo study: oxidative and metabolic damage occurred in a dose-dependent manner with increasing particle concentration [ 16 ]. Studies show that PM 2.5 will not be completely removed by the human body in a short time, and a small part will accumulate in the lungs or be transferred to regional lymph nodes [ 35 ].…”

Section: Discussionsupporting

confidence: 90%

“…The composition of PM 2.5 is very complex and diverse, containing a range of toxic substances such as heavy metals, polycyclic aromatic hydrocarbons (PAHs), sulfates, bacteria, and viruses [ 14 , 15 ]. The sub-micron toxic substances can enter the respiratory system and penetrate the intima or enter the capillary lumen via endocytosis [ 16 ]. Shimada et al found that PM 2.5 could enter blood circulation in a short time through the “interstitial permeation pathway” induced by the air–blood barrier.…”

Section: Introductionmentioning

confidence: 99%

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Hemolytic Properties of Fine Particulate Matter (PM2.5) in In Vitro Systems

Bai,

Zhang,

Shao

et al. 2024

Toxics

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Epidemiological studies have suggested that inhalation exposure to particulate matter (PM) air pollution, especially fine particles (i.e., PM2.5 (PM with an aerodynamic diameter of 2.5 microns or less)), is causally associated with cardiovascular health risks. To explore the toxicological mechanisms behind the observed adverse health effects, the hemolytic activity of PM2.5 samples collected during different pollution levels in Beijing was evaluated. The results demonstrated that the hemolysis of PM2.5 ranged from 1.98% to 7.75% and demonstrated a clear dose–response relationship. The exposure toxicity index (TI) is proposed to represent the toxicity potential of PM2.5, which is calculated by the hemolysis percentage of erythrocytes (red blood cells, RBC) multiplied by the mass concentration of PM2.5. In a pollution episode, as the mass concentration increases, TI first increases and then decreases, that is, TI (low pollution levels) < TI (heavy pollution levels) < TI (medium pollution levels). In order to verify the feasibility of the hemolysis method for PM toxicity detection, the hemolytic properties of PM2.5 were compared with the plasmid scission assay (PSA). The hemolysis results had a significant positive correlation with the DNA damage percentages, indicating that the hemolysis assay is feasible for the detection of PM2.5 toxicity, thus providing more corroborating information regarding the risk to human cardiovascular health.

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Section: Discussionsupporting

confidence: 90%