Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial

Pakfetrat, Maryam; Basiri, Fatemeh; Malekmakan, Leila; Roozbeh, Jamshid

doi:10.1007/s40620-014-0039-2

Cited by 74 publications

(78 citation statements)

References 32 publications

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“…Its effect on itching in randomized trials was less than gabapentin, and its most common side effect is insomnia (14). There remains a need for a more robust evidence base for these and other agents, such as turmeric, montelukast, zinc sulfate, and nalbuphine (15)(16)(17)36).…”

Section: Discussionmentioning

confidence: 99%

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International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis

Rayner¹,

Larkina²,

Mia³

et al. 2017

CJASN

159

205

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Background and objectives Uremic pruritus in patients on hemodialysis is associated with depression, lower quality of life, and mortality. We studied the prevalence, awareness, and treatment of pruritus to assess how well this important condition is currently managed internationally.Design, setting, participants, & measurements Data from 35,452 patients on hemodialysis in up to 17 countries from the Dialysis Outcomes and Practice Patterns Study were analyzed to describe pruritus prevalence from 1996 to 2015. Data from 6256 patients and 268 medical directors in 17 countries in 2012-2015 were analyzed to describe predictors, effects, medical directors' awareness, and treatment of pruritus.Results Patients very much or extremely bothered by itching declined from 28% in 1996 to 18% in 2015. In 2012-2015, among patients nearly always or always bothered by itching, pruritus had a major effect on work and social life; 18% used no treatment for pruritus, and 17% did not report itching to health care staff. In total, 69% of medical directors underestimated the prevalence of pruritus in their unit. Managing high serum phosphorus and low Kt/V was ranked as the most important intervention, but no relationship was found between these factors and pruritus; 57% of medical directors used oral antihistamines for first-line chronic treatment of pruritus. Gabapentin was used by 45% as first-, second-, or third-line treatment. Nalfurafine was only used in Japan.Conclusions The prevalence of pruritus in people on hemodialysis is decreasing but remains underestimated. Large numbers of patients on hemodialysis with severe pruritus do not receive treatment. There is wide variation in the use of unlicensed medications for the treatment of pruritus. These data provide a benchmark for initiatives to improve the management of uremic pruritus.

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Section: Discussionmentioning

confidence: 99%

“…Single randomized, controlled trials of turmeric, montelukast, and zinc sulfate have shown a significant reduction in itch compared with placebo and warrant further study (15)(16)(17).…”

Section: Introductionmentioning

confidence: 96%

International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis

Rayner¹,

Larkina²,

Mia³

et al. 2017

CJASN

159

205

View full text Add to dashboard Cite

show abstract

“…In particular, the evaluation of treatment efficacy from non-controlled, non-blinded, and/ or underpowered trials is problematic. First, the importance of control groups in pruritus studies is illustrated by the dramatic improvements in itching in these groups in CKDaP trials, up to 80% in a study by Duque et al 64,67 Second, double-blinding participants and investigators are important given the subjective nature of pruritus. There is a potential for bias when participants or investigators are aware of assigned groups, as this may influence pruritus assessments.…”

Section: Challenges Of Treatmentmentioning

confidence: 99%

“…64 In a 4-week RCT of 50 HD patients, oral nicotinamide significantly improved pruritus compared to placebo. 65 Two non-controlled trials showed that pentoxyfilline and sericin cream improved CKD-aP; however, these results have not been confirmed with a subsequent RCT.…”

mentioning

confidence: 99%

Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges

Shirazian¹,

Aina²,

Park³

et al. 2017

IJNRD

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Chronic kidney disease-associated pruritus (CKD-aP) is a distressing, often overlooked condition in patients with CKD and end-stage renal disease. It affects ~40% of patients with end-stage renal disease and has been associated with poor quality of life, poor sleep, depression, and mortality. Prevalence estimates vary based on the instruments used to diagnose CKD-aP, and standardized diagnostic instruments are sorely needed. Treatment studies have often yielded conflicting results. This is likely related to studies that are limited by small sample size, flawed designs, and nonstandardized diagnostic instruments. Several large well-designed treatment trials have recently been completed and may soon influence CKD-aP management.

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“…This difference implies that HD patients with UP have an overactivity of Th1 (14). In another study, turmeric decreased UP and high-sensitivity C-reactive protein (HS-CRP), possibly because of its antiinflammatory properties (15).…”

Section: Introductionmentioning

confidence: 98%

Effects of Fumaria parviflora L on Uremic Pruritus in Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

Akrami

Hashempur

Tavakoli

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Uremic pruritus (UP) is a common, bothersome symptom in hemodialysis (HD) patients with end-stage renal disease. Immunohypothesis is currently favored as an explanation of the cause of UP. Fumaria parviflora L (FP) is a medicinal herb with several pharmacological properties, including prominent anti-inflammatory activity. Objectives: This study aimed to assess the efficacy of FP for reducing UP severity among HD patients. Methods: A total of 79 HD patients with pruritus were randomly assigned to receive either FP or a placebo for eight weeks. The visual analogue scale (VAS), the Duo score for calculating pruritus score, serum interferon-γ (IFN-γ) level, interleukin-4 (IL-4), and high-sensitivity C-reactive protein were measured in the patients before and after treatment. Results: At the end of the treatment phase, the pruritus score decreased in both groups (P < 0.001); however, the mean reduction

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Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial

Abstract: This study demonstrates the possible efficacy of turmeric in decreasing hs-CRP and uremic pruritus in end stage renal disease patients. Future studies are needed to further evaluate the efficacy and safety of turmeric.

Cited by 74 publications

References 32 publications

International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis

International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis

Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges

Effects of Fumaria parviflora L on Uremic Pruritus in Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

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