Effects of triiodothyronine (T3) on the potentiation by antidepressants of l-5-hydroxytryptophan-induced head-twitches in mice

Antidepressant-like effect of novel 5-HT3 receptor antagonist N-n-butyl-3-ethoxyquinoxalin-2-carboxamide (6p): An approach using rodent behavioral antidepressant tests

“…The antidepressant-like effect of 6p appears to be modulated by an increase in monoamines’ level, particularly 5-HT concentrations in the synapse. [22] In the current investigation, pargyline and 5-HTP–induced head twitch response were significantly increased by 6p and paroxetine treatment.…”

Antidepressant-like effect of novel 5-HT3 receptor antagonist N-n-butyl-3-ethoxyquinoxalin-2-carboxamide (6p): An approach using rodent behavioral antidepressant tests

“…The antidepressant-like effect of 6p appears to be modulated by an increase in monoamines’ level, particularly 5-HT concentrations in the synapse. [22] In the current investigation, pargyline and 5-HTP–induced head twitch response were significantly increased by 6p and paroxetine treatment.…”

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“…This effect provides a model for the study of antidepressants. This model proved an attractive model for the study of transmitter interactions with 5-HTergic mechanisms and verified a role for dopaminergic 40 and noradrenergic [41][42][43] mechanisms in the modulation of the 5-HTergic head-twitch response. This test provides a relatively rapid and accurate index of SSRI potency in vivo.…”

Antidepressant & anxiolytic activities of N-(pyridin-3-yl) quinoxalin-2-carboxamide

“…In our previous studies121317, 5-HT 3 receptor antagonist showed the antidepressant activity at higher dose without the anxiolytic effect. The possible anxiolytic and antidepressant activities of QCF-21 may result from its interaction with diversely localized 5-HT 3 receptors and/or from the indirect influence on neurotransmitter systems which are thought to contribute to the modulation of emotional states.…”

“…5-Hydroxy tryptophan induced head twitch response (5-HTP-HTR) : The method has been described elsewhere17. QCF-21 pretreated mice were treated (p.o.)…”

Antidepressant-like effect of novel 5-HT3 receptor antagonist N-n-butyl-3-ethoxyquinoxalin-2-carboxamide (6p): An approach using rodent behavioral antidepressant tests

“…The antidepressant-like effect of 6p appears to be modulated by an increase in monoamines’ level, particularly 5-HT concentrations in the synapse. [22] In the current investigation, pargyline and 5-HTP–induced head twitch response were significantly increased by 6p and paroxetine treatment.…”

Untitled

“…This effect provides a model for the study of antidepressants. This model proved an attractive model for the study of transmitter interactions with 5-HTergic mechanisms and verified a role for dopaminergic 40 and noradrenergic [41][42][43] mechanisms in the modulation of the 5-HTergic head-twitch response. This test provides a relatively rapid and accurate index of SSRI potency in vivo.…”

Antidepressant & anxiolytic activities of N-(pyridin-3-yl) quinoxalin-2-carboxamide

“…In our previous studies121317, 5-HT 3 receptor antagonist showed the antidepressant activity at higher dose without the anxiolytic effect. The possible anxiolytic and antidepressant activities of QCF-21 may result from its interaction with diversely localized 5-HT 3 receptors and/or from the indirect influence on neurotransmitter systems which are thought to contribute to the modulation of emotional states.…”

“…5-Hydroxy tryptophan induced head twitch response (5-HTP-HTR) : The method has been described elsewhere17. QCF-21 pretreated mice were treated (p.o.)…”

Antidepressant-like effect of novel 5-HT3 receptor antagonist N-n-butyl-3-ethoxyquinoxalin-2-carboxamide (6p): An approach using rodent behavioral antidepressant tests

“…The antidepressant-like effect of 6p appears to be modulated by an increase in monoamines’ level, particularly 5-HT concentrations in the synapse. [22] In the current investigation, pargyline and 5-HTP–induced head twitch response were significantly increased by 6p and paroxetine treatment.…”

Untitled

“…This effect provides a model for the study of antidepressants. This model proved an attractive model for the study of transmitter interactions with 5-HTergic mechanisms and verified a role for dopaminergic 40 and noradrenergic [41][42][43] mechanisms in the modulation of the 5-HTergic head-twitch response. This test provides a relatively rapid and accurate index of SSRI potency in vivo.…”

Antidepressant & anxiolytic activities of N-(pyridin-3-yl) quinoxalin-2-carboxamide

“…In our previous studies121317, 5-HT 3 receptor antagonist showed the antidepressant activity at higher dose without the anxiolytic effect. The possible anxiolytic and antidepressant activities of QCF-21 may result from its interaction with diversely localized 5-HT 3 receptors and/or from the indirect influence on neurotransmitter systems which are thought to contribute to the modulation of emotional states.…”

“…5-Hydroxy tryptophan induced head twitch response (5-HTP-HTR) : The method has been described elsewhere17. QCF-21 pretreated mice were treated (p.o.)…”