Effects of tretinoin on photodamaged skin. A histologic study

Bhawan, Jag

doi:10.1001/archderm.127.5.666

Cited by 63 publications

(56 citation statements)

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“…RA remains the gold standard to reverse some aspects of the regressive changes in chronologic aging an photoaging [1, 2, 3, 4, 5, 6, 7]. Our results conform to previous reports.…”

Section: Discussionsupporting

confidence: 92%

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Comparative Effects of Retinoic Acid, Glycolic Acid and a Lipophilic Derivative of Salicylic Acid on Photodamaged Epidermis

Pierard

Kligman²,

Stoudemayer³

et al. 1999

Dermatology

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Background: Studies comparing purported antiaging compounds are rare. Objective: To compare in a randomized, placebo-controlled double-blind study 10% glycolic acid (GA), 2% 2-hydroxy-5-octanoyl benzoic acid (β-lipohydroxy acid, LSA) and 0.05% all-trans-retinoic acid (RA). Methods: Women volunteers treated one forearm twice daily with one of the active products and the other one with the vehicle. Comparative evaluations of efficacy were made using histochemistry and quantitative immunohistochemistry. Results: Improvement in the various epidermal compartments was the most prominent finding at the RA-treated site. The LSA-treated site also exhibited similar positive changes, although to a lesser degree. GA showed no significant effect. Conclusion: In the presently tested concentrations and formulations, RA had a beneficial impact upon the aging epidermis. LSA mimicked RA but with somewhat lesser efficacy. By contrast, GA appeared almost inactive.

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“…RA remains the gold standard to reverse some aspects of the regressive changes in chronologic aging an photoaging [1, 2, 3, 4, 5, 6, 7]. Our results conform to previous reports.…”

Section: Discussionsupporting

confidence: 92%

“…The corrective influence of retinoids on the proliferation and differentiation of keratinocytes has been documented conclusively [1, 2, 3, 4, 5, 6, 7]. Even short-term applications of RA (1 month) can increase epidermal thickness and modify markers of terminal differentiation [6].…”

Section: Introductionmentioning

confidence: 99%

Comparative Effects of Retinoic Acid, Glycolic Acid and a Lipophilic Derivative of Salicylic Acid on Photodamaged Epidermis

Pierard

Kligman²,

Stoudemayer³

et al. 1999

Dermatology

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“…An additional study should be useful for evaluating the efficacy of 0.05% retinaldehyde cream on epidermal damage following UVB irradiation in the same ex vivo skin model, since epidermal damage has previously been shown to improve with tretinoin treatment [3]. …”

Section: Discussionmentioning

confidence: 99%

“…Indeed, histological epidermal changes have been described in tretinoin-treated human subjects, i.e. increased epidermal thickness, increased granular layer thickness, decreased melanin content and stratum corneum compaction [3]. At the dermal level, improvement of connective tissue was observed in tretinoin-treated photodamaged skin [4]as well as increased glycosaminoglycans [5], new collagen formation (types I and III) [6, 7]and improvement of elastic fibers [4].…”

Section: Introductionmentioning

confidence: 99%

Repair of UVA-Induced Elastic Fiber and Collagen Damage by 0.05% Retinaldehyde Cream in an ex vivo Human Skin Model

et al. 1999

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Background: Cellular effects of UV exposure are implicated in cutaneous aging. UV radiations induce structural and cellular changes in all the compartments of skin. Aim: To study the antiaging efficacy of a cream containing 0.05% retinaldehyde with an ex vivo technique using human skin in order to approximate in vivo metabolic conditions. Methods: Human skin explants were maintained alive in organ culture for 18 days and subjected to UVA exposure, thus simulating skin photoaging. Retinaldehyde cream was then applied to the surface of the epidermis for 2 weeks and the results were compared with those of nontreated skin explants. Dermal repair was analyzed histologically with quantification of collagen and elastic fibers, and biochemically by the measure of newly synthesized collagen as shown by adding tritiated proline to the culture medium. Results: UVA exposure induced significant alterations of collagen and elastic fibers as shown by morphometric analysis. In all UVA-exposed and then retinaldehyde-treated skin specimens, collagen and elastic fibers were restored to the level of nonexposed skin. UVA exposure induced a decrease in collagen synthesis, whereas in retinaldehyde-treated UVA-exposed skin the synthesis was similar to that of unexposed skin. Conclusion: It has been shown that retinaldehyde has many of the properties of tretinoin in its biological and beneficial effects on photoaging. We have verified some of these previous observations, especially on dermal connective tissue, by obtaining significant repair of elastic fibers and collagen alteration induced by UVA exposure.

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“…Several studies that have been reported in the literature measured the melanin content for various skin types and suggest that p mel ranges from approximately 3% for light skin to 50% for dark skin. [31][32][33][34][35] We represent light, moderately pigmented, and dark skin by using the values p mel ϭ 5, 25, 50%, respectively.…”

Section: Methodsmentioning

confidence: 99%

Optimum pulse duration and radiant exposure for vascular laser therapy of dark port-wine skin: a theoretical study

Tunnell¹,

Wang²,

Anvari³

2003

Appl. Opt.

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Laser therapy for cutaneous hypervascular malformations such as port-wine stain birthmarks is currently not feasible for dark-skinned individuals. We study the effects of pulse duration, radiant exposure, and cryogen spray cooling ͑CSC͒ on the thermal response of skin, using a Monte Carlo based optical-thermal model. Thermal injury to the epidermis decreases with increasing pulse duration during irradiation at a constant radiant exposure; however, maintaining vascular injury requires that the radiant exposure also increase. At short pulse durations, only a minimal increase in radiant exposure is necessary for a therapeutic effect to be achieved because thermal diffusion from the vessels is minimal. However, at longer pulse durations the radiant exposure must be greatly increased. There exists an optimum pulse duration at which minimal damage to the epidermis and significant injury within the targeted vasculature occur. For example, the model predicts optimum pulse durations of approximately 1.5, 6, and 20 ms for vessel diameters of 40, 80, and 120 m, respectively. Optimization of laser pulse duration and radiant exposure in combination with CSC may offer a means to treat cutaneous lesions in dark-skinned individuals.

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Effects of tretinoin on photodamaged skin. A histologic study

Cited by 63 publications

References 0 publications

Comparative Effects of Retinoic Acid, Glycolic Acid and a Lipophilic Derivative of Salicylic Acid on Photodamaged Epidermis

Comparative Effects of Retinoic Acid, Glycolic Acid and a Lipophilic Derivative of Salicylic Acid on Photodamaged Epidermis

Repair of UVA-Induced Elastic Fiber and Collagen Damage by 0.05% Retinaldehyde Cream in an ex vivo Human Skin Model

Optimum pulse duration and radiant exposure for vascular laser therapy of dark port-wine skin: a theoretical study

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