volume 93, issue 0, P3-O-082 2020
DOI: 10.1254/jpssuppl.93.0_3-o-082
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Abstract: Introduction] It is recently reported that sustained activation of inflammasomes (cytosolic protein complexes) in microglia and neural progenitor cells (NPC) may induce neuroinflammation and impaired neurogenesis in neurodegenerative diseases. While liver X receptor (LXR) activation induces transcription of lipid metabolism related genes through a mechanism called transactivation, the activation suppresses expression of genes, such as interleukin-6 (IL-6) and IL-1beta, a mechanism called transrepression. We ha…

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