2018
DOI: 10.1590/0103-8478cr20170071
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Effects of tramadol and acepromazine on intraocular pressure and pupil diameter in young healthy cats

Abstract: This study aimed to investigate the effects of the systemic administration of acepromazine, tramadol and the association of both on intraocular pressure (IOP) and pupil diameter (PD) in young healthy cats. Cats were randomly allocated into three groups (n=10/each) and intramuscular acepromazine (AG), tramadol (TG) or acepromazine combined with tramadol (ATG) were injected. PD (electronic caliper) and IOP (applanation tonometry) were assessed before (baseline) and following 15, 30, 60, and 120 minutes of treatm… Show more

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Cited by 5 publications
(11 citation statements)
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References 16 publications
(38 reference statements)
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“…However, the parameter had a significant decrease at the 15th and 20th min in the M group, compared to baseline time, but it was not significant in the MA group. In a study by Schroder et al (2018) that investigated the effects of tramadol and Acepromazine and their combination on dog eye factors, they found that injection of acepromazine alone or in combination with…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…However, the parameter had a significant decrease at the 15th and 20th min in the M group, compared to baseline time, but it was not significant in the MA group. In a study by Schroder et al (2018) that investigated the effects of tramadol and Acepromazine and their combination on dog eye factors, they found that injection of acepromazine alone or in combination with…”
Section: Discussionmentioning
confidence: 99%
“…In a study by Schroder et al. (2018) that investigated the effects of tramadol and Acepromazine and their combination on dog eye factors, they found that injection of acepromazine alone or in combination with tramadol did not cause any significant changes in the intraocular pressure. Injecting Acepromazine alone to dogs in the first 30 min caused a significant increase and then a decrease in the intraocular pressure, but no significant change occurred in intraocular pressure in the Acepromazine‐tramadol group during this period, probably due to the predominant effect of Acepromazine on tramadol.…”
Section: Discussionmentioning
confidence: 99%
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“…In many cases, the neuroleptoanalgesia afforded by acepromazine increases the weak analgesic effect of the opioid. In particular, this pre-anesthetic association has also been considered a suitable option for ophthalmic surgery in cats [ 88 ], with benefits such as unaltered intraocular pressure and sustained mydriasis when co-administered with tramadol (3 mg/kg IM), distinct from acepromazine alone (0.05 mg/kg IM) [ 89 ]. The analgesic potency of 2 mg/kg IM tramadol or EPI tramadol co-administered with lidocaine (3 mg/kg EPI) was also evaluated in terms of painful mechanical stimuli following pressure application from hemostatic forceps in the skin of several body regions.…”
Section: Therapeutic Efficacy Of Tramadol In Catsmentioning
confidence: 99%
“…The effects of systemic opioid narcotics on the PD vary greatly between species and between classes of mixed and pure opioid agonists (Sharp, 1991). One study has demonstrated that tramadol alone or in association with acepromazine caused significant mydriasis and did not change IOP values in normal cats (Schroder et al, 2018).…”
Section: Introductionmentioning
confidence: 99%