Effects of topical mechlorethamine on skin lesions of psoriasis

Epstein, E.

doi:10.1001/archderm.102.5.504

Cited by 15 publications

(4 citation statements)

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“…The results obtained from the model parallel those known for the treatment of psoriasis. Thus, in a previous publication (du Vivier & Stoughton, 1975) we have shown that 5-fluorouracil and nitrogen mustard topically are effective in the hairless mouse system as they are clinically (Nurse, 1963;Epstein & Ugel, 1970). Systemic cyclophosphamide is also effective in both situations (Higgins & Thompson, 1966) whereas topical cyclophosphamide is ineffective (du Vivier & Stoughton, 1975).…”

Section: Discussionmentioning

confidence: 93%

An animal model for screening drugs for antipsoriatic properties using hydroxyapatite to isolate DNA rapidly from the epidermis

et al. 1976

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A new, rapid, simple and accurate procedure for extracting DNA from the epidermis is described involving hydroxyapatite. This compound has an unique property of high affinity for double stranded native DNA, but none for RNA and protein. The technique has been applied to a hairless mouse model for screening systemic and topical agents for cell inhibitory properties in proliferating epidermis for potential use in the therapy of psoriasis. Mitotic counts, autoradiography and a standard chloroform procedure for isolating DNA have confirmed the results obtained using hydroxyapatite column chromatography. In addition, compounds which are known to be effective in psoriasis, have been found to be effective in the system suggesting that it should be a good predictive screen for new therapies. Of several compounds screened for topical activity, cycloheximide has been found to be very effective in the system and preliminary clinical studies confirm its efficacy in psoriasis.

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Section: Discussionmentioning

confidence: 93%

An animal model for screening drugs for antipsoriatic properties using hydroxyapatite to isolate DNA rapidly from the epidermis

et al. 1976

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“…Both PUVA therapy (Parrish et al, 1974) and topically applied mechlorethamine (Epstein & Ugel, 1970;Mandy, Taylor & Halprin, I97t) have been demonstrated to be eflfective in the treatment of psoriasis. The commonest complication of topical mechlorethamine therapy is the development of contact dermatitis which may be ofthe irritant or more frequently ofthe allergic type involving delayed hypersensitivity.…”

Section: Discussionmentioning

confidence: 99%

PUVA therapy prevents sensitization to mechlorethamine in patients with psoriasis

1985

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Two groups of 20 patients with psoriasis were treated with mechlorethamine applied topically (group A) or with PUVA combined with mechlorethamine (group B). In group B mechlorethamine was started after six PUVA treatments.Results showed a significant decrease of the incidence of contact dermatitis in group B (30%) compared with group A (75%). Allergic dermatitis, demonstrated by a positive patch test to mechlorethaniine with an histology of eczema, was observed in 55% of patients in group A and 20% in group B. The incidence of irritant dermatitis was not significantly different in the two groups. Allergic dermatitis was observed later in group B: after an average of 32 2 applications of mechlorethamine compared with 25 applications in group A.Possible mechanisms responsible for these results are reduction of epidermal Langerhans cells by PUVA therapy and induction of antigen-specific suppressor T cells.Patients living far from a specialized centre might be treated initially with PUVA therapy then with mechlorethamine alone, at home. This schedule may reduce the incidence of contact dermatitis to mechlorethamine.Correspondence: Pr. J.Thivolet.

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“…This was described by Van Scott and Eeinertson (1959). Epstein and Ugel (1970) reported 12 patients so treated. The response was good in 10, but nine developed hypersensitivity reactions during eight months.…”

Section: Introductionmentioning

confidence: 99%