2020
DOI: 10.1155/2020/8948723
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Abstract: Reactive oxygen species (ROS) at a normal level are important molecules involved in several cellular processes including immune response and cell signalling. Overproduction of ROS may lead to elevated oxidative stress and consequently to age-related diseases. Most of the studies related to oxidative stress in humans have been done on blood samples. However, blood sampling might be painful, requires special qualified personnel, and has to be performed at medical centers. An alternative to blood is saliva. Saliv… Show more

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Cited by 5 publications
(3 citation statements)
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References 47 publications
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“…Exercise and increased muscle activity result in higher amounts of ROS due to increased ATP production and oxygen utilisation [ 312 ]. ROS are highly reactive and can damage macromolecules such as proteins, DNA, and lipids.…”
Section: Health Effectsmentioning
confidence: 99%
See 1 more Smart Citation
“…Exercise and increased muscle activity result in higher amounts of ROS due to increased ATP production and oxygen utilisation [ 312 ]. ROS are highly reactive and can damage macromolecules such as proteins, DNA, and lipids.…”
Section: Health Effectsmentioning
confidence: 99%
“…ROS such as peroxides and superoxides can be damaging to cells if concentrations are excessive [ 313 , 314 ]. Regular exercise builds resistance of the body against oxidative stress by upregulating the expression of genes that synthesise antioxidant enzymes such as superoxide dismutase [ 312 ].…”
Section: Health Effectsmentioning
confidence: 99%
“…It is ubiquitous in the body, chemically stable in biological fluids and widely considered a reliable, sensitive and specific non-invasive biomarker of in vivo systemic OS [ 17 , 18 ]. Recently it has been speculated that 15-F 2t -IsoP excretion is associated with 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dGuo or 8-oxo-dG) [ 19 , 20 ], a guanine modification induced by free radicals and adopted as a non-invasive biomarker of OS [ 21 ]. The accumulation of such damages can lead to genetic information changes, and, consequently, to mutagenesis and cells apoptosis [ 22 ].…”
Section: Introductionmentioning
confidence: 99%