Effects of Tobacco Smoke Exposure in Childhood on Atopic Diseases

Ciaccio, Christina E.; Gentile, Deborah A.

doi:10.1007/s11882-013-0389-1

Cited by 30 publications

(26 citation statements)

References 52 publications

(46 reference statements)

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“…In line to this, nicotine has been shown to reduce atopic disorders such as asthma and preeclampsia [30]. Mechanism of action in these cases may be, nicotine interfering with the inflammationrelated disease process, as nicotine has vaso-constrictive effects [31].…”

Section: Discussionmentioning

confidence: 95%

In vivo effect of chronic nicotine exposure on outcome of Plasmodium berghei ANKA malaria

Ketema¹,

Bacha²,

Yohannes³

et al. 2017

APJTD

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Section: Discussionmentioning

confidence: 95%

In vivo effect of chronic nicotine exposure on outcome of Plasmodium berghei ANKA malaria

Ketema¹,

Bacha²,

Yohannes³

et al. 2017

APJTD

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“…Another study (29) reported that higher expression of CD14 and TLR genes was related to protective factors (farming environments, endotoxin, extracellular polysaccharides) against the development of asthma and wheezing in children. Air pollutants such as those contained in environmental tobacco smoke present a considerable health problem to the general population, including non-smokers (16,(30)(31)(32). Some studies suggest that active and passive smoking present the risk of IgE sensitisation and atopic conditions, atopic rhinitis and dermatitis in particular (32,33).…”

Section: Discussionmentioning

confidence: 99%

“…Air pollutants such as those contained in environmental tobacco smoke present a considerable health problem to the general population, including non-smokers (16,(30)(31)(32). Some studies suggest that active and passive smoking present the risk of IgE sensitisation and atopic conditions, atopic rhinitis and dermatitis in particular (32,33). Our study however found no correlation between passive smoking and elevated IgE in either atopic or non-atopic adolescents, but in atopics passive smoking showed a borderline significant effect on sCD14 levels.…”

Section: Discussionmentioning

confidence: 99%

Soluble CD14 and total IgE in the serum of atopic and nonatopic adolescents in relation to environmental factors: a pilot study / Topivi receptor CD14 i ukupni IgE u serumu mladih atopičara odrasle dobi u ovisnosti o čimbenicima iz okoliša: pilot istraživanje

Prester

Varnai

Macan

2015

Archives of Industrial Hygiene and Toxicology

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The CD14 receptor is expressed on the surfaces of monocytes, macrophages, and, to a lesser extent, of activated granulocytes and B lymphocytes (mCD14). It also exists in soluble form in the serum (sCD14), in which it binds microbial compounds and indoor allergens. The objectives of this study were to see whether serum sCD14 concentrations could be used as a marker of atopic disorders and to estimate the effects of environmental factors (tobacco smoke exposure, childhood residence in urban or rural areas, and having a pet) on sCD14 and IgE values. Mass fraction of sCD14 and total IgE were determined in the sera of atopic (N=53) and non-atopic (N=35) participants using the standard enzyme-linked immunosorbent assay. Exposure to pets and environmental tobacco smoke was estimated based on the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC). Median sCD14 concentration was significantly lower in atopic than in non-atopic girls (3.49 vs. 3.83 μg mL -1 ; p<0.010). The number of smokers at home positively correlated with the sCD14 level in atopics, and urban atopics had significantly lower sCD14 levels than rural atopics (3.47 vs. 3.92 μg mL -1 , p=0.028). Median total IgE concentration was significantly lower in atopic pet owners than in atopics with no pets (161 vs. 252 kIU L -1 ; p=0.021). In conclusion, while sex and environmental factors might be involved in sCD14 expression, particularly in atopics, we found no correlation between sCD14 and total IgE concentrations. The usefulness of sCD14 as a marker of atopic disorders should be investigated further, particularly in relation to the severity of allergic disorders.KEY WORDS: allergy; atopy; environmental tobacco smoke; immunoglobulin E; sCD14; pets Prester Lj, et al. Soluble CD14 and total IgE in the serum of atopic and non-atopic adolescents in relation to environmental factors: a pilot study Arh Hig Rada Toksikol 2015;66:41-49

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“…The cytomorphological and functional integrity of these membranesis animportant element of the first line of defense against the effectsof unfavorable environmental factors associated with exposure to tobacco smoke [14][15][16]. Tobacco smoke can trigger allergic sensitization that directly affects immunoglobulin-E at the cellular level and can increase the permeability of the epithelium of the airways, further reducing its function as a protective barrier [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

The Role of Genetic Polymorphism of IL-4 (C-589T) and TNfa (G-308A) and Regular Passive Smoking in Clinical Manifestations of Pneumonia in Infants

Kuzmenko¹,

Aryayev²,

Lowe³

2016

Clin Pediatr

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Objective: This study set out to investigate the relationship between molecular-genetic mechanisms that modulate cytokine in infants whose parents expose them to cigarette smoke and those that do not expose their infants to cigarette smoke with the possible effects on the severity of pneumonia at presentation to hospital. Methods:This cross sectional study recruited infants and parents from a regional Children's Hospital. The infants where classified into three groups:1. Where the infant was exposed to cigarette smoke through the mother directly (N = 50). 2. The mother did not smoke but the infant was exposed to tobacco smoke from the relatives in the family (N = 50). 3. The infant was in a family in which no one smoked. Analysis of genetic polymorphisms (regional frequencies) and determination of CRP and IgE concentrations were performed to investigate if exposure to cigarette smoke could be linked to the severity of pneumonia.Results: Exposure to cigarette smoke in infants changed the likelihood of the severity of pneumonia. The results suggest a possible link between the duration of clinical manifestation of pneumonia within infants that are exposed to cigarette smoke. Infants who are exposed to cigarette smoke had higher plasma concentrates in both IgE and CRP. Among infants with the mutant variant of the TNF-α (G-308A) gene, infants from households where both parents smoked or had a father who smoked had longer duration of clinical signs of pneumonia than did infants with no exposure to tobacco smoke. The plasma concentration of IgE in infants in families where one or both parents smoke was significantly higher than in infants with no smoke exposure. Conclusion:The study begins to develop evidence that if the newborn infant is exposed to tobacco smoke either directly from their mother or from others in the household including automobiles, the severity of pneumonia is increased. Both nurses and pediatricians should reinforce the consequences of smoke around the baby to all parents at every opportunity.

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Effects of Tobacco Smoke Exposure in Childhood on Atopic Diseases

Cited by 30 publications

References 52 publications

In vivo effect of chronic nicotine exposure on outcome of Plasmodium berghei ANKA malaria

In vivo effect of chronic nicotine exposure on outcome of Plasmodium berghei ANKA malaria

Soluble CD14 and total IgE in the serum of atopic and nonatopic adolescents in relation to environmental factors: a pilot study / Topivi receptor CD14 i ukupni IgE u serumu mladih atopičara odrasle dobi u ovisnosti o čimbenicima iz okoliša: pilot istraživanje

The Role of Genetic Polymorphism of IL-4 (C-589T) and TNfa (G-308A) and Regular Passive Smoking in Clinical Manifestations of Pneumonia in Infants

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