Effects of Three Colloid Solutions on Plasma Volume and Hemodynamics After Coronary Bypass Surgery

Karanko, Meri S.

doi:10.1097/00003246-198711000-00006

Cited by 24 publications

(6 citation statements)

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“…The purpose of using volume expanders after cardiac bypass surgery is to maintain stable haemodynamics 2. Applying an appropriate fluid with enough volume at this stage may prevent systemic hypoperfusion and cellular hypoxia, which lead to systemic lactic acidosis 3.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the effects of gelatin, Ringer's solution and a modern hydroxyl ethyl starch solution after coronary artery bypass graft surgery : cardiovascular topic

Alavi

Baharvand-Ahmadi²,

Baharestani³

et al. 2012

CVJA

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ObjectiveThe aim of this study was to compare the effect of 6% hydroxyl ethyl starch solution with 4% gelatin and Ringer’s solutions on the haemodynamic stability of patients after coronary artery bypass graft (CABG) surgery and immediately after discontinuation of cardiopulmonary bypass (CPB).MethodsThis was a randomised, double-blind clinical trial of 92 patients who were candidates for on-pump CABG. After discontinuation of CPB, all patients were transferred to the intensive care unit (ICU) and divided randomly into three groups. The first group received Ringer’s solution, the second group 4% gelatin, and the third 6% hydroxyl ethyl starch (HES) solution (Voluven). Haemodynamic parameters such as heart rate, mean arterial pressure, systolic blood pressure, diastolic blood pressure, central venous pressure, cardiac output and the presence of arrhythmias were documented.ResultsThe volume needed for maintaining normal blood pressure and central venous pressure in the range of 10–14 mmHg was less in the HES group than in the other groups. The volume was similar however in the gelatin and Ringer’s groups in the first 24 hours after surgery. Urinary output in the first four and 24 hours after surgery were significantly higher in the HES group than in the other two groups. Mean creatinine levels were significantly lower in the HES group.ConclusionHES (6%) had a better volume-expanding effect than gelatin (4%) and Ringer’s solutions, and its short-term effects on renal function were also better than gelatin and Ringer’s solutions.

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Section: Introductionmentioning

confidence: 99%

Comparison of the effects of gelatin, Ringer's solution and a modern hydroxyl ethyl starch solution after coronary artery bypass graft surgery : cardiovascular topic

Alavi

Baharvand-Ahmadi²,

Baharestani³

et al. 2012

CVJA

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“…It has been shown to have good PV expanding properties, in some studies even superior to that of all other colloids studied, in states of normal capillary permeability 18,19 and in states of increased capillary permeability. 20,21 Based on recent studies, the use of HES is no longer recommended in sepsis, 22 which has reduced the synthetic colloid treatment alternatives in the critically ill patients to a minimum. This could mean an increased interest in the use of dextran.…”

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confidence: 99%

Infusion rate and plasma volume expansion of dextran and albumin in the septic guinea pig

Bark

Grände

2013

Acta Anaesthesiol Scand

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“…The hemodynamic profiles of various colloids have been quite similar because the rate of colloid infusion has been relatively slow. The administration of HES (130, 200 kDa), gelatin, or albumin resulted in comparable hemodynamics during 20-48 h in patients undergoing cardiac or abdominal surgery [46][47][48][49][50][51]. Similar hemodynamics were also observed with HES 200 kDa or gelatin in patients with sepsis and during normovolemic hemodilution in patients who had undergone hip arthroplasty [52][53][54].…”

Section: Colloid Choice For Hypovolemiamentioning

confidence: 90%

Colloid solutions: a clinical update

2010

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Albumin, dextran, gelatin, and hydroxyethyl starch (HES) solutions are colloids that efficiently expand the circulating blood volume. The administration of colloids restores the intravascular volume with minimal risk of tissue edema in comparison with crystalloid solutions alone. However, colloids are always given for surgical and critically ill patients. The type of the colloid, volumes applied, aggressiveness of fluid resuscitation, and the volume status at the initial phase of administration determine their clinical responses. The outcome after fluid resuscitation with various colloids in critically ill patients seems to be comparable according to systematic reviews. A randomized, adequately powered clinical trial comparing modern nonprotein colloid to albumin is still lacking. Rapidly degradable HES solutions have good hemodynamic effects, and the risk of adverse renal and coagulation effects, as well as allergic reactions, is minimal. The current investigation has also shown the beneficial effect of HES solution (especially HES 130/0.4) on inflammatory response, postoperative nausea and vomiting, and postoperative outcome. The indication of colloids with an assessment of the degree of hypovolemia and safety profiles should thus be taken into consideration before colloid administration.

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Effects of Three Colloid Solutions on Plasma Volume and Hemodynamics After Coronary Bypass Surgery

Cited by 24 publications

References 0 publications

Comparison of the effects of gelatin, Ringer's solution and a modern hydroxyl ethyl starch solution after coronary artery bypass graft surgery : cardiovascular topic

Comparison of the effects of gelatin, Ringer's solution and a modern hydroxyl ethyl starch solution after coronary artery bypass graft surgery : cardiovascular topic

Infusion rate and plasma volume expansion of dextran and albumin in the septic guinea pig

Colloid solutions: a clinical update

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