Effects of the topical hemostatic agent Ankaferd Blood Stopper on the incidence of alveolar osteitis after surgical removal of an impacted mandibular third molar

Tek, Mustafa; Akkaş, İsmail; Toptaş, Orçun; Özan, Fatih; Şener, İsmail; Bereket, Cihan

doi:10.4103/1119-3077.122847

Cited by 19 publications

(16 citation statements)

References 59 publications

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“…The proteomics of the structural and functional properties of the proteins related to the wound healing should also be matched with the already established proteomics of ABS [41]. Experimental trials indicated that ABS is effective in wound healing [39,42,43,44,45,46,47]. The results of our present study disclosed that ABS has antimicrobial effects against bacteria that are active in wound and burn complications.…”

Section: Discussionmentioning

confidence: 54%

Antibacterial Activities of Ankaferd Hemostat (ABS) on Shiga Toxin-Producing Escherichia coli and Other Pathogens Significant in Foodborne Diseases

Koluman¹,

Akar²,

Haznedaroğlu³

2017

Tjh

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Objective:Ankaferd hemostat (Ankaferd Blood Stopper®, ABS)-induced pharmacological modulation of essential erythroid proteins can cause vital erythroid aggregation via acting on fibrinogen gamma. Topical endoscopic ABS application is effective in the controlling of gastrointestinal (GI) system hemorrhages and/or infected GI wounds. Escherichia coli O157:H7, the predominant serotype of enterohemorrhagic E. coli, is a cause of both outbreaks and sporadic cases of hemorrhagic colitis. The aim of this study is to examine the effects of ABS on 6 different Shiga toxigenic E. coli serotypes including O26, O103, O104, O111, O145, and O157 and on other pathogens significant in foodborne diseases, such as Salmonella Typhimurium, Campylobacter jejuni, and Listeria monocytogenes, were also assessed.Materials and Methods:All strains were applied with different amounts of ABS and antimicrobial effect was screened. S. Typhimurium groups were screened for survival using the fluorescence in situ hybridization technique.Results:The relative efficacy of ABS solutions to achieve significant logarithmic reduction in foodborne pathogens E. coli O157:H7 and non-O157 serogroups and other emerging foodborne pathogens is demonstrated in this study. ABS has antibacterial effects.Conclusion:Our present study indicated for the first time that ABS may act against E. coli O157:H7, which is a cause of thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome, and hemorrhagic colitis. The interrelationships between colitis, infection, and hemostasis within the context of ABS application should be further investigated in future studies.

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Section: Discussionmentioning

confidence: 54%

Antibacterial Activities of Ankaferd Hemostat (ABS) on Shiga Toxin-Producing Escherichia coli and Other Pathogens Significant in Foodborne Diseases

Koluman¹,

Akar²,

Haznedaroğlu³

2017

Tjh

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“…Alveolar osteitis is a common complication after extraction of impacted mandibular third molars. The incidence varies from 0 to 45%. The treatment method used to manage the alveolar osteitis in this study was emphasised in an earlier study to be reliable in the management of this condition.…”

Section: Discussionmentioning

confidence: 96%

Comparison of treatment outcome between symptomatic and asymptomatic impacted mandibular third molars: a pilot study

Anyanechi

Saheeb

2017

Oral Surgery

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Aim:To determine and compare the treatment outcome between symptomatic and asymptomatic impacted mandibular third molars in the same patients who presented with bilateral impacted mandibular third molars. Methods: This preliminary study was done at the Dental and Maxillofacial Surgery Clinic of our institution over a period of 18 months. The variables analysed were age, gender, socio-economic class, duration of symptoms before treatment, types of impaction and complaints during the follow-up. Descriptive and bivariate statistics were computed and the P value was set at 0.05. Results: The sample was composed of 27 patients, and their ages ranged from 18 to 41 years with a mean age of 31 AE 2.3 years. There were more males than females, with male: female ratio of 1.1:1. The complication rate was 8 (29.6%) in 5/27 (18.5%) patients under symptomatic wisdom teeth impaction while in asymptomatic impacted teeth, the rate was 2 (7.4%) in 2/27 (7.4%) patients and this difference was significant (P = 0.02). The complications occurred only in patients in the lower socio-economic class (P = 0.01) and in symptomatic cases, the longer the duration of symptoms before treatment, the more the complications (P = 0.001). The complications following treatment were alveolar osteitis, numbness of the ipsilateral lower lip and hypersensitivity of the adjacent second molar. Conclusion: This study shows that the surgical extractions of symptomatic and asymptomatic impacted mandibular third molars were associated with post-operative complications that were more in the symptomatic cases. The findings in this study may have to be investigated further in a future study. Clinical relevanceScientific rationale for studyThe prophylactic surgical extraction of asymptomatic impacted mandibular third molars in the absence of defined indication is controversial among researchers in clinical dental surgery practice. Principal findingsThe surgical extractions of symptomatic and asymptomatic impacted mandibular third molars were Oral Surgery 10 (2017) e40--e47.

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“…In another study which was conducted by 25 patients who were undergone bronchoscopy procedure, ABS has successfully controlled the bleeding episodes of the cases (Uzun et al 2014). There are three different clinical studies which confirms ABS as a successful hemostatic agent that was conducted with 25, 50 and 113 patients, respectively (Kazancıoğlu et al 2013; Tek et al 2014; Beyazit et al 2011). ABS could also be used in gynecological cases.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical efficacy of ABS in numerous systems had been demonstrated in the literature. For instance; ABS is very effective in the controlling of hemorrhages within the gingival tissue (Amer et al 2014), lung tissue (Uzun et al 2014), tooth extraction (Kazancıoğlu et al 2013; Tek et al 2014; Beyazit et al 2011), perineal tissue (Eyi et al 2013), oral mucosa tissue (Leblebisatan et al 2012), gastrointestinal tissue (Karaman et al 2012), thyroid tissue (Guler et al 2011), nasopharyngeal tissue (Iynen et al 2011; Yasar and Ozkul 2011), nasal tissue (Teker et al 2010), peritonsillary tissue (Teker et al 2009). Also, it has been reported that partial nephrectomy operation in human was performed without any complication with ABS (Huri et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural analyses of the novel chimeric hemostatic agent generated via nanotechnology, ABS nanohemostat, at the renal tissue level

et al. 2016

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Ankaferd Blood Stopper (ABS), a hemostatic agent of plant origin, has been registered for the prevention of clinical hemorrhages. Currently there is no data regarding the ultrastructural analysis of ABS at the tissue level. The aim of this study is to assess renal tissue effects via scanning electron microscopy (SEM) analyses for the ABS and ABS nanohemostat (formed by the combination of self-assembling peptide amphiphile molecules and ABS). SEM experiments were performed with FEI Nova NanoSEM 230, using the ETD detector at low vacuum mode with 30 keV beam energy. SEM analyses revealed that significant erythroid aggregation are present inside the capillary bed of the renal tissue. However, neither the signs of necrosis nor any other sign of tissue damage are evident in the surrounding renal tissue supplied by the microcapillary vasculature. Our study is important for several reasons. Firstly, in our study we used ABS nanohemostat which was recently developed. This study adds valuable information to the literature regarding ABS nanohemostat. Secondly, this study is the first ultrastructural analysis of ABS that was performed at the tissue level. Thirdly, we disclosed that ABS nanohemostat could induce vital erythroid aggregation at the renal tissue level as detected by SEM. Lastly, we detected that ABS nanohemostat causes no harm to the tissues including necrosis and any other detrimental effects.

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Effects of the topical hemostatic agent Ankaferd Blood Stopper on the incidence of alveolar osteitis after surgical removal of an impacted mandibular third molar

Abstract: The results showed that ABS administration did not increase the incidence of AO formation. Thus, ABS can be used safely for hemostasis after impacted mandibular third molar surgery.

Cited by 19 publications

References 59 publications

Antibacterial Activities of Ankaferd Hemostat (ABS) on Shiga Toxin-Producing Escherichia coli and Other Pathogens Significant in Foodborne Diseases

Antibacterial Activities of Ankaferd Hemostat (ABS) on Shiga Toxin-Producing Escherichia coli and Other Pathogens Significant in Foodborne Diseases

Comparison of treatment outcome between symptomatic and asymptomatic impacted mandibular third molars: a pilot study

Ultrastructural analyses of the novel chimeric hemostatic agent generated via nanotechnology, ABS nanohemostat, at the renal tissue level

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