Effects of the spermicide nonoxynol-9 on the pregnant uterus and the conceptus of rat

Amended Final Report on the Safety Assessment of Nonoxynol-1, -2, -3, -4, -5, -6, -7, and -81

“…For dams dosed on day 7, 9.2 normal implantation sites per uterus and 4.8 resorption sites per uterus were found. Compared to the saline-treated control group, the number of normal implantation sites was smaller and the number of resorption sites was greater in experimental groups; the difference was significant (p < 0.01) (Tryphonas and Buttar 1986).…”

Amended Final Report on the Safety Assessment of Nonoxynol-1, -2, -3, -4, -5, -6, -7, and -81

“…For dams dosed on day 7, 9.2 normal implantation sites per uterus and 4.8 resorption sites per uterus were found. Compared to the saline-treated control group, the number of normal implantation sites was smaller and the number of resorption sites was greater in experimental groups; the difference was significant (p < 0.01) (Tryphonas and Buttar 1986).…”

Final Report on the Safety Assessment of Octoxynol-1, Octoxynol-3, Octoxynol-5, Octoxynol- 6, Octoxynol-7, Octoxynol-8, Octoxynol-9, Octoxynol-10, Octoxynol-11, Octoxynol-12, Octoxynol-13, Octoxynol-16, Octoxynol-20, Octoxynol-25, Octoxynol-30, Octoxynol-33, Octoxynol-40, Octoxynol-70, Octoxynol-9 Carboxylic Acid, Octoxynol-20 Carboxylic Acid, Potassium Octoxynol-12 Phosphate, Sodium Octoxynol-2 Ethane Sulfonate, Sodium Octoxynol-2 Sulfate, Sodium Octoxynol-6 Sulfate, and Sodium Octoxynol-9 Sulfate1

“…For dams dosed on day 7, 9.2 normal implantation sites per uterus and 4.8 resorption sites per uterus were found. Compared to the saline-treated control group, the number of normal implantation sites was smaller and the number of resorption sites was greater in experimental groups; the difference was significant ( p < .01) (Tryphonas and Buttar 1986).…”

“…The investigators also stated that whether the lack of genotoxic response was due to low affinity of the male germinal cells for Nonoxynol-9 and its metabolites, or to the existence of a blood-testicular barrier in adult mice was not known (Buttar, Swierenga, and Matula 1986). Tryphonas and Buttar (1986) evaluated the embryotoxicity of Nonoxynol-9 using groups of nulliparous female Wistar rats (five per group; weights = 180-200 g). Each rat was dosed intravaginally with 5 mg Nonoxynol-9/100 g (0.1 ml Nonoxynol/100g) on GDs 3 and 7.…”

Male Reproductive Health and Environmental Xenoestrogens

“…Intravaginal administration of nonoxynol-9 in rats caused damage to the vaginal epithelium and acute inflammation in the vagina, cervix, and uterus (61). When administered to rats during the first week of pregnancy, nonoxynol was found to be embryotoxic (62).…”

Amended Final Report on the Safety Assessment of Nonoxynol-1, -2, -3, -4, -5, -6, -7, and -81

“…For dams dosed on day 7, 9.2 normal implantation sites per uterus and 4.8 resorption sites per uterus were found. Compared to the saline-treated control group, the number of normal implantation sites was smaller and the number of resorption sites was greater in experimental groups; the difference was significant (p < 0.01) (Tryphonas and Buttar 1986).…”

Final Report on the Safety Assessment of Octoxynol-1, Octoxynol-3, Octoxynol-5, Octoxynol- 6, Octoxynol-7, Octoxynol-8, Octoxynol-9, Octoxynol-10, Octoxynol-11, Octoxynol-12, Octoxynol-13, Octoxynol-16, Octoxynol-20, Octoxynol-25, Octoxynol-30, Octoxynol-33, Octoxynol-40, Octoxynol-70, Octoxynol-9 Carboxylic Acid, Octoxynol-20 Carboxylic Acid, Potassium Octoxynol-12 Phosphate, Sodium Octoxynol-2 Ethane Sulfonate, Sodium Octoxynol-2 Sulfate, Sodium Octoxynol-6 Sulfate, and Sodium Octoxynol-9 Sulfate1

“…For dams dosed on day 7, 9.2 normal implantation sites per uterus and 4.8 resorption sites per uterus were found. Compared to the saline-treated control group, the number of normal implantation sites was smaller and the number of resorption sites was greater in experimental groups; the difference was significant ( p < .01) (Tryphonas and Buttar 1986).…”

“…The investigators also stated that whether the lack of genotoxic response was due to low affinity of the male germinal cells for Nonoxynol-9 and its metabolites, or to the existence of a blood-testicular barrier in adult mice was not known (Buttar, Swierenga, and Matula 1986). Tryphonas and Buttar (1986) evaluated the embryotoxicity of Nonoxynol-9 using groups of nulliparous female Wistar rats (five per group; weights = 180-200 g). Each rat was dosed intravaginally with 5 mg Nonoxynol-9/100 g (0.1 ml Nonoxynol/100g) on GDs 3 and 7.…”

Male Reproductive Health and Environmental Xenoestrogens

“…Intravaginal administration of nonoxynol-9 in rats caused damage to the vaginal epithelium and acute inflammation in the vagina, cervix, and uterus (61). When administered to rats during the first week of pregnancy, nonoxynol was found to be embryotoxic (62).…”

Amended Final Report on the Safety Assessment of Nonoxynol-1, -2, -3, -4, -5, -6, -7, and -81

“…For dams dosed on day 7, 9.2 normal implantation sites per uterus and 4.8 resorption sites per uterus were found. Compared to the saline-treated control group, the number of normal implantation sites was smaller and the number of resorption sites was greater in experimental groups; the difference was significant (p < 0.01) (Tryphonas and Buttar 1986).…”

Final Report on the Safety Assessment of Octoxynol-1, Octoxynol-3, Octoxynol-5, Octoxynol- 6, Octoxynol-7, Octoxynol-8, Octoxynol-9, Octoxynol-10, Octoxynol-11, Octoxynol-12, Octoxynol-13, Octoxynol-16, Octoxynol-20, Octoxynol-25, Octoxynol-30, Octoxynol-33, Octoxynol-40, Octoxynol-70, Octoxynol-9 Carboxylic Acid, Octoxynol-20 Carboxylic Acid, Potassium Octoxynol-12 Phosphate, Sodium Octoxynol-2 Ethane Sulfonate, Sodium Octoxynol-2 Sulfate, Sodium Octoxynol-6 Sulfate, and Sodium Octoxynol-9 Sulfate1

“…For dams dosed on day 7, 9.2 normal implantation sites per uterus and 4.8 resorption sites per uterus were found. Compared to the saline-treated control group, the number of normal implantation sites was smaller and the number of resorption sites was greater in experimental groups; the difference was significant ( p < .01) (Tryphonas and Buttar 1986).…”

“…The investigators also stated that whether the lack of genotoxic response was due to low affinity of the male germinal cells for Nonoxynol-9 and its metabolites, or to the existence of a blood-testicular barrier in adult mice was not known (Buttar, Swierenga, and Matula 1986). Tryphonas and Buttar (1986) evaluated the embryotoxicity of Nonoxynol-9 using groups of nulliparous female Wistar rats (five per group; weights = 180-200 g). Each rat was dosed intravaginally with 5 mg Nonoxynol-9/100 g (0.1 ml Nonoxynol/100g) on GDs 3 and 7.…”

Male Reproductive Health and Environmental Xenoestrogens

“…Intravaginal administration of nonoxynol-9 in rats caused damage to the vaginal epithelium and acute inflammation in the vagina, cervix, and uterus (61). When administered to rats during the first week of pregnancy, nonoxynol was found to be embryotoxic (62).…”