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Cited by 116 publications
(71 citation statements)
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References 24 publications
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“…After comprehensive literature review, our Divisions of Neonatology and Infectious Disease recommended that RV5 be administered in the NICU with routine 2-month vaccinations to infants receiving some amount of enteral nutrition. [5][6][7][8][9] The reported RV5 shedding rate at that time was 8.9% of infants. 7 The risk of symptomatic transmission was thought to be low due to the poor replication of bovine-human vaccine in human intestines.…”
Section: Resultsmentioning
confidence: 99%
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“…After comprehensive literature review, our Divisions of Neonatology and Infectious Disease recommended that RV5 be administered in the NICU with routine 2-month vaccinations to infants receiving some amount of enteral nutrition. [5][6][7][8][9] The reported RV5 shedding rate at that time was 8.9% of infants. 7 The risk of symptomatic transmission was thought to be low due to the poor replication of bovine-human vaccine in human intestines.…”
Section: Resultsmentioning
confidence: 99%
“…Viral shedding rates after the first dose of RV5 vary in the literature from 1% to 87%, particularly due to differences in frequency of stool sampling and stool testing methods (enzyme-linked immunosorbent assay, PCR, or culture). 8,11,12,15,16 Shedding seems to be highest after the first dose and among preterm infants. 7,12 This shedding with RV5 is rarely associated significant clinical disease in immunocompetent patients or transmission to household contacts.…”
Section: Discussionmentioning
confidence: 99%
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“…However, the vaccine was withdrawn from the market in less than a year because its delivery was associated with intussusception [10]. Recently, two RV vaccines, RotaTeq and Rotarix, were developed and shown to efficiently protect against severe diarrhea, however, they are produced using live attenuated RV strains [11][12][13][14][15]. Besides the side effects, live attenuated vaccines have the risk of possible virulence reversion.…”
mentioning
confidence: 99%