Effects of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat

The Influence of Endotoxemia on the Pharmacokinetics and the Electroencephalographic Effect of Propofol in the Rat

“…It is interesting to note that Chaudry et al19 showed that normal liver enzyme levels did not preclude hepatocellular dysfunction. Increased plasma creatinine levels after administration of endotoxin seen in our experiments were also observed by others,15,20,21 and reflect impaired renal function. The mild hypothermia observed in the present study after endotoxin administration contrasts with the study of Rosser et al14 showing no change in body temperature.…”

The Influence of Endotoxemia on the Pharmacokinetics and the Electroencephalographic Effect of Propofol in the Rat

“…It is interesting to note that Chaudry et al19 showed that normal liver enzyme levels did not preclude hepatocellular dysfunction. Increased plasma creatinine levels after administration of endotoxin seen in our experiments were also observed by others,15,20,21 and reflect impaired renal function. The mild hypothermia observed in the present study after endotoxin administration contrasts with the study of Rosser et al14 showing no change in body temperature.…”

Role for endogenous endothelin in the regulation of plasma volume and albumin escape during endotoxin shock in conscious rats

“…The present results raise the question of whether endogenous ET‐1 would be beneficial in endotoxin shock, as suggested by Ruetten et al . (1996).…”

Effect of the endothelin receptor antagonist tezosentan on alpha‐naphthylthiourea‐induced lung injury in rats

“…Similarly, Ruetten et al. [45] found that pretreatment with a nonselective ET receptor antagonist in endotoxin‐challenged rats markedly augmented hemodynamic deterioration and reduced the 6‐hour survival rate. Conversely, Rossi et al.…”

The Influence of Endotoxemia on the Pharmacokinetics and the Electroencephalographic Effect of Propofol in the Rat

“…It is interesting to note that Chaudry et al19 showed that normal liver enzyme levels did not preclude hepatocellular dysfunction. Increased plasma creatinine levels after administration of endotoxin seen in our experiments were also observed by others,15,20,21 and reflect impaired renal function. The mild hypothermia observed in the present study after endotoxin administration contrasts with the study of Rosser et al14 showing no change in body temperature.…”

Role for endogenous endothelin in the regulation of plasma volume and albumin escape during endotoxin shock in conscious rats

“…The present results raise the question of whether endogenous ET‐1 would be beneficial in endotoxin shock, as suggested by Ruetten et al . (1996).…”

Effect of the endothelin receptor antagonist tezosentan on alpha‐naphthylthiourea‐induced lung injury in rats

“…Similarly, Ruetten et al. [45] found that pretreatment with a nonselective ET receptor antagonist in endotoxin‐challenged rats markedly augmented hemodynamic deterioration and reduced the 6‐hour survival rate. Conversely, Rossi et al.…”

The Influence of Endotoxemia on the Pharmacokinetics and the Electroencephalographic Effect of Propofol in the Rat

“…It is interesting to note that Chaudry et al19 showed that normal liver enzyme levels did not preclude hepatocellular dysfunction. Increased plasma creatinine levels after administration of endotoxin seen in our experiments were also observed by others,15,20,21 and reflect impaired renal function. The mild hypothermia observed in the present study after endotoxin administration contrasts with the study of Rosser et al14 showing no change in body temperature.…”

Role for endogenous endothelin in the regulation of plasma volume and albumin escape during endotoxin shock in conscious rats

“…The present results raise the question of whether endogenous ET‐1 would be beneficial in endotoxin shock, as suggested by Ruetten et al . (1996).…”

Effect of the endothelin receptor antagonist tezosentan on alpha‐naphthylthiourea‐induced lung injury in rats

“…Similarly, Ruetten et al. [45] found that pretreatment with a nonselective ET receptor antagonist in endotoxin‐challenged rats markedly augmented hemodynamic deterioration and reduced the 6‐hour survival rate. Conversely, Rossi et al.…”