Effects of the chorda tympani damage on submandibular glands: scintigraphic changes

Yağmur, Cengiz; Miman, MC; Karataş, Erkan; Akarçay, Mustafa; Erdem, Tamer; Özturan, Orhan

doi:10.1258/002221504772784531

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…99m Tc-pertechnetate uptake and clearance by major salivary glands correlate with salivary flow rates. 21 It is like that 99m Tc-pertechnetate uptake can be changed whether there is secretor unit damage. Concurrently, clearance may be reflecting a non-secretory ability, due to any drug use or compromised central nervous system stimulation.…”

Section: Discussionmentioning

confidence: 99%

Major salivary gland damage in allogeneic hematopoietic progenitor cell transplantation assessed by scintigraphic methods

Coracin

Corrêa

Camargo

et al. 2006

Bone Marrow Transplant

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Salivary gland dysfunction is a common sequela of hematopoietic progenitor cell transplantation (HPCT). The investigation of major salivary gland dysfunction with sodium pertechnetate scintigraphy is a non-invasive method that provides images of the parotid and submandibular glands. In this prospective trial, 20 HPCT patients were submitted to scintigraphic study with 99m Tcpertechenate and 67 Ga in order to evaluate the major salivary glands early involvement following HPCT. Major salivary glands were evaluated prior to HCPT as well as at Days þ 30, þ 60 and þ 100 post transplant. Major salivary glands uptake and clearance of 99m Tc-pertechenate results did not demonstrate any functional differences between pre-versus post transplant periods. Results of the 67 Ga scan revealed inflammatory infiltration following HPCT, primarily in submandibular glands, suggest a persistent involvement of major salivary glands up to Day þ 100 after HPCT. Bone Marrow Transplantation (2006) 37, 955-959.

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Section: Discussionmentioning

confidence: 99%

Major salivary gland damage in allogeneic hematopoietic progenitor cell transplantation assessed by scintigraphic methods

Coracin

Corrêa

Camargo

et al. 2006

Bone Marrow Transplant

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“…it had hypertrophied), rather than the ipsilateral gland being smaller. In the second study, the ability of the denervated gland to take up, concentrate and secrete radioisotope was significantly reduced 45 . Therefore, it seems that unilateral chorda tympani damage impairs the function of the ipsilateral submandibular salivary gland but does not cause atrophy 45 …”

Section: What Are the Effects Of Chorda Tympani Injury?mentioning

confidence: 92%

Iatrogenic injury of the chorda tympani: a systematic review

2011

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“…Thus, atrophy of submandibular gland could be considered on the operated side in the late postoperative period. According to the TcPertechnetate uptake and excretion of the submandibular gland are correlated with the rate of saliva excretion [11]. In a study including 16 patients of whom 11 had canal wall-down tympanoplasty and 5 had radical mastoidectomy, the function of each submandibular gland was investigated by scintigraphy before and after treatment.…”

Section: Discussionmentioning

confidence: 99%

The changes in submandibular gland size and function following chorda tympani section

Uzun¹,

Özkırış

Kubilay

2011

Eur Arch Otorhinolaryngol

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To investigate the effects of chorda tympani section on submandibular gland size and function in the early (postoperative day 7) and late (postoperative month 6) postoperative period by ultrasonography, scintigraphy, and biochemical analysis of the saliva patients with unilateral chronic otitis media. One-hundred and thirty patients (46 males and 84 females) who were ≥16 years of age and diagnosed with unilateral chronic otitis media and for whom type 1 tympanoplasty was indicated in 1st Outpatient Clinic of Kartal Dr. Lutfi Kirdar Training and Research Hospital between August 2004 and February 2007 were enrolled in the study. Of 130 patients, 102 patients who were eligible and gave written approval were included in the study. However, of these patients 99 underwent type 1 tympanoplasty and 3 had a canal down mastoidectomy. In 99 patients, chorda tympani nerves of 16 were cut, but 3 patients had to be excluded due to allergic reactions. Before the operation, bilateral submandibular gland ultrasonography was performed on all patients and the anterior-posterior length, the frontal lateral-medial width (transverse), and the paramandibular depth of both submandibular glands were measured. In scintigraphic examinations, perfusion index (PI), uptake ratio and excretion fraction were measured. Then, in biochemical analysis of the saliva the levels of sodium, potassium, chloride, calcium, magnesium, amylase, and the values of pH and density were assessed by the saliva collection through Wharton duct. In the statistical comparison of operated and healthy side of the patients with respect to these parameters Mann-Whitney U test, and in intragroup analysis Wilcoxon test was used. The volume of the submandibular gland of the operated side was significantly lower compared to the healthy side in postoperative month 6 (P < 0.05). According to the baseline volume of the submandibular gland of the healthy side, the increase in postoperative day 7 and month 6 were found to be statistically insignificant (P > 0.05). According to the baseline PI value, the decreases in the PI value in the postoperative day 7 and postoperative month 6 were statistically significant (P < 0.01). The uptake ratio of the patients was lower in the postoperative day 7 and month 6 than those at the baseline; however, the difference was statistically insignificant (P > 0.05). The excretion fraction values in the postoperative day 7 were significantly lower than the baseline values (P < 0.05), whereas the decrease in the EF values in the postoperative month 6 were statistically insignificant (P > 0.05). In conclusion, the present study was the first in the literature in which three parameters of assessment, such as ultrasonography, scintigraphy, and biochemical analysis, were used to determine the changes in submandibular gland size and function following the chorda tympani section. After chorda tympani section, the volume of submandibular gland decreased in the late postoperative period. Moreover, chorda tympani section led to decrease in the saliva secretio...

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Effects of the chorda tympani damage on submandibular glands: scintigraphic changes

Cited by 6 publications

References 6 publications

Major salivary gland damage in allogeneic hematopoietic progenitor cell transplantation assessed by scintigraphic methods

Major salivary gland damage in allogeneic hematopoietic progenitor cell transplantation assessed by scintigraphic methods

Iatrogenic injury of the chorda tympani: a systematic review

The changes in submandibular gland size and function following chorda tympani section

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