Effects of the Chemical Structure and the Surface Properties of Polymeric Biomaterials on Their Biocompatibility

Wang, You-Xiong; Robertson, John L.; Spillman, William B.; Claus, Richard O.

doi:10.1023/b:pham.0000036909.41843.18

Cited by 338 publications

(263 citation statements)

References 88 publications

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“…The surface properties of an implanted biomaterial are of the utmost importance for its biocompatibility. As for a biomaterial surface, the cell-material interaction is strongly influenced by not only surface topography but also by surface chemistry (physicochemical property) including surface wettability (surface energy) and surface charge [1][2][3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

Adhesion of mouse fibroblasts on hexamethyldisiloxane surfaces with wide range of wettability

et al. 2006

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Surface wettability is an important physicochemical property of biomaterials, and it would be more helpful for understanding this property if a wide range of wettability are employed. This study focused on the effect of surface wettability on fibroblast adhesion over a wide range of wettability using a single material without changing surface topography. Plasma polymerization with hexa methyldisiloxane followed by oxygen (O 2 ) plasma treatment was employed to modify the surfaces. The water contact angle of sample surfaces varied from 106 degrees (hydrophobicity) to almost 0 degrees (super-hydrophilicity). O 2 -functional groups were introduced on polymer surfaces during O 2 -plasma treatment. The cell attachment study confirmed that the more hydrophilic the surface, the more fibroblasts adhered in the initial stage that includes on super-hydrophilic surfaces. Cells spread much more widely on the hydrophilic surfaces than on the hydrophobic surfaces. There was no significant difference in fibroblast proliferation, but cell spreading was much greater on the hydrophilic surfaces. These findings suggest the importance of the surface wettability of biomaterials on initial cell attachment and spreading. The degree of wettability should be taken into account when a new biomaterial is to be employed. Further research of surface wettability on adhesive molecules is necessary for a better understanding of this property.

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Section: Introductionmentioning

confidence: 99%

Adhesion of mouse fibroblasts on hexamethyldisiloxane surfaces with wide range of wettability

et al. 2006

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“…A high water level on the surface of the biomaterial provides a low interfacial tension with blood, thus reducing fibrinogen adsorption, cell adhesion and clot formation, (Abraham, 2002;Faibish, 2002;Van Krevelen, 1990;Wang, 2004). The results are presented in Fig 2. It is observed that the water uptake is given by the PEA-PU sample (reference polyurethane sample without hydroxypropylcellulose, PEA/MDI/EG, M n =109.613, M w /M n =1.3), PEA-HPC and PTHF-HPC samples (151 %, 140 % and 167 %, respectively ) and in a less extent by the PPG-HPC (92 %) due to its less polar soft segment having the lateral -CH 3 substituent which confer a different geometry to the polyurethane internal microporous structure, unfavorable for water uptake.…”

Section: Water Sorptionmentioning

confidence: 99%

“…In case of the preferentially fibrinogen adsorption (important protein in endogenous haemostasis), platelet adhesion is increased followed by thrombus activation and clot formation. In case of albumin absorbtion platelet adhesion is diminished which confer to the surface a thromboresistant character, (Bajpai, 2005;Wang et al, 2004). Fig.…”

Section: Platelet Adhesionmentioning

confidence: 99%

Natural-Based Polyurethane Biomaterials for Medical Applications

Macocinschi¹,

Filip²,

Vlad³

2011

Biomaterials Applications for Nanomedicine

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“…These methods do not require hazardous chemicals, yet still have the capability to modify the surface while imparting less degradation and roughness compared to wet chemical surface modification techniques [26]. In addition, the film deposited on the polymer surface can be manipulated by changing the deposition rate, energy range and surface topography [97]. Plasma pre-treatment has also been used prior to attaching collagen to a polymer nanofiber mesh, a method that showed increased cell attachment, spreading and viability [98].…”

Section: Attachment Of Pharmaceuticals Biopharmaceuticals or Biomolementioning

confidence: 99%

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

Govindarajan

Shandas

2014

Polymers

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Abstract:The search for a single material with ideal surface properties and necessary mechanical properties is on-going, especially with regard to cardiovascular stent materials. Since the majority of stent problems arise from surface issues rather than bulk material deficiencies, surface optimization of a material that already contains the necessary bulk properties is an active area of research. Polymers can be surface-modified using a variety of methods to increase hemocompatibilty by reducing either late-stage restenosis or acute thrombogenicity, or both. These modification methods can be extended to shape memory polymers (SMPs), in an effort to make these materials more surface compatible, based on the application. This review focuses on the role of surface modification of materials, mainly polymers, to improve the hemocompatibility of stent materials; additional discussion of other materials commonly used in stents is also provided. Although shape memory polymers are not yet extensively used for stents, they offer numerous benefits that may make them good candidates for next-generation stents. Surface modification techniques discussed here include roughening, patterning, chemical modification, and surface modification for biomolecule and drug delivery.

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Effects of the Chemical Structure and the Surface Properties of Polymeric Biomaterials on Their Biocompatibility

Cited by 338 publications

References 88 publications

Adhesion of mouse fibroblasts on hexamethyldisiloxane surfaces with wide range of wettability

Adhesion of mouse fibroblasts on hexamethyldisiloxane surfaces with wide range of wettability

Natural-Based Polyurethane Biomaterials for Medical Applications

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

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