Effects of the calcium ionophore A23187 on airway responsiveness to histamine and substance P in guinea pigs

Uno, Daisuke; Tsukagoshi, Hideo; Hisada, Takeshi; Iwamae, Shigenori; Mori, Masataka

doi:10.1007/s000110050125

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…It is known that a Ca ionophore induced airway hyper-responsiveness to intravenous histamine and substance P possibly by reducing NO levels in the airway tissues. This may be due to damaged airway epithelium and/or NO breakdown by activated inflammatory cells in the airway [17]. It is speculated that there is correlation between Ca levels in BALF and the damage of the airway epithelium in the dogs with bronchopneumonia.…”

Section: Resultsmentioning

confidence: 95%

Trace and Major Elements Status in Bronchoalveolar Lavage Fluid in Dogs with or without Bronchopneumonia

Suzuki

Yamaya

Kanzawa

et al. 2008

Biol Trace Elem Res

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The aim of this study was to investigate the relationships between the bronchopneumonia and mean concentrations of those trace elements in bronchoalveolar lavage fluid (BALF). Twenty-nine dogs were included this study (17 healthy dogs and 12 dogs with respiratory disease). Each BALF sample had been obtained during bronchoscope examination by use of a standardized method. The concentrations of Al, Br, Ca, Cu, Fe, K, Ni, P, Si, Sr and Zn in BALF were measured by the particle-induced X-ray emission method. We found no relationship between the bronchopneumonia and the levels of elements in the BALF, except Ca, P and Zn. The dogs with respiratory disease were found to have a large amount of Ca and Zn, and a high Ca/P and Zn/Cu ratios in BALF compared to those without respiratory disease.

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Section: Resultsmentioning

confidence: 95%

Trace and Major Elements Status in Bronchoalveolar Lavage Fluid in Dogs with or without Bronchopneumonia

Suzuki

Yamaya

Kanzawa

et al. 2008

Biol Trace Elem Res

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“…It is known that a calcium ionophore induces airway hyper-responsiveness to intravenous histamine and substance P possibly by reducing the nitric oxide levels in the airway tissues. This may be due to damaged airway epithelium and/or NO breakdown by activated inflammatory cells in the airway [28]. It is speculated that there is a correlation between Ca levels in BALF and the damage of the airway epithelium in calves with Mycoplasma bronchopneumonia.…”

Section: Discussionmentioning

confidence: 96%

Analysis of Trace and Major Elements in Bronchoalveolar Lavage Fluid of Mycoplasma Bronchopneumonia in Calves

Suzuki

Higuchi

Iwano

et al. 2011

Biol Trace Elem Res

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The aim of this study was to evaluate the reliability and effectiveness of direct determination of trace and major element concentrations in bronchoalveolar lavage fluid samples from Holstein calves with Mycoplasma bronchopneumonia (n = 21) and healthy controls (n = 20). The samples were obtained during bronchoscopy using a standard examination method. A total of 18 elements (aluminum, bromine, calcium, chlorine, chromium, copper, iron, potassium, magnesium, manganese, molybdenum, nickel, phosphorous, sulfur, silicon, strontium, titanium, and zinc) were detected by particle-induced X-ray emission. The average bromine, iron, potassium, magnesium, and phosphorous concentrations were higher in calves with bronchopneumonia than in controls (p < 0.05). They were found to have higher amounts of calcium and zinc, and a higher zinc-copper ratio than that in healthy calves (p < 0.001). Based on the receiver operating characteristics curves, we propose a diagnostic cutoff point for zinc-copper ratio for identification of Mycoplasma pneumonia of 8.676. Our results indicate that assessment of the elemental composition of broncholaveolar lavage fluid is a promising diagnostic tool for Mycoplasma bronchopneumonia.

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4-Hydroxy-2-Nonenal Enhances Fibronectin Production by IMR-90 Human Lung Fibroblasts Partly via Activation of Epidermal Growth Factor Receptor-Linked Extracellular Signal-Regulated Kinase p44/42 Pathway

Tsukagoshi

Kawata

Shimizu

et al. 2002

Toxicology and Applied Pharmacology

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Effects of the calcium ionophore A23187 on airway responsiveness to histamine and substance P in guinea pigs

Abstract: These data suggest that A23187 exposure induced AHR to SP possibly by reducing NO levels in the airway tissues. This may be due to damaged airway epithelium and/or NO breakdown by activated inflammatory cells in the airways of these guinea pigs.

Cited by 6 publications

References 24 publications

Trace and Major Elements Status in Bronchoalveolar Lavage Fluid in Dogs with or without Bronchopneumonia

Trace and Major Elements Status in Bronchoalveolar Lavage Fluid in Dogs with or without Bronchopneumonia

Analysis of Trace and Major Elements in Bronchoalveolar Lavage Fluid of Mycoplasma Bronchopneumonia in Calves

4-Hydroxy-2-Nonenal Enhances Fibronectin Production by IMR-90 Human Lung Fibroblasts Partly via Activation of Epidermal Growth Factor Receptor-Linked Extracellular Signal-Regulated Kinase p44/42 Pathway

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