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Cited by 38 publications
(7 citation statements)
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“…It has been reported that the addition of thalidomide di rectly into human leukocyte cultures causes a reduction in spontaneous blast transformation [7] and that two derivates of thalidomide inhibit the human mixed lymphocyte reac tion but not PH A activation [8], In this work, we observed no significant in vitro effect of thalidomide at three different concentrations (5, 25 and 50 pg/ml) on PPD-induced lym phocyte activation (table 1). These concentrations are far more higher than the 1.15±0.2 pg/ml plasma peak concen tration of thalidomide expected to be reached in humans 6 h after administration of200 mg of the drug [ 11].…”
Section: Discussioncontrasting
confidence: 42%
See 1 more Smart Citation
“…It has been reported that the addition of thalidomide di rectly into human leukocyte cultures causes a reduction in spontaneous blast transformation [7] and that two derivates of thalidomide inhibit the human mixed lymphocyte reac tion but not PH A activation [8], In this work, we observed no significant in vitro effect of thalidomide at three different concentrations (5, 25 and 50 pg/ml) on PPD-induced lym phocyte activation (table 1). These concentrations are far more higher than the 1.15±0.2 pg/ml plasma peak concen tration of thalidomide expected to be reached in humans 6 h after administration of200 mg of the drug [ 11].…”
Section: Discussioncontrasting
confidence: 42%
“…Lymphocyte proliferation after antigen stimulation is a very important step during the induction and expression of an immune response and the effect of thalidomide on this lymphocyte function remains controversial [7][8][9].…”
Section: Introductionmentioning
confidence: 99%
“…These results are in disagreement with several earlier investigations suggesting that thalidomide might depress the immune response (Dukor and Dietrich, 1968): for instance, this compound has been reported to delay the rejection of skin homografts in mice (Hellmann et al, 1965), and the IgM antibody response of both mice and leprous patients (Shannon et al, 1981), and to prevent acute graft versus host (GvH) disease in rats (Vogelsang et al, 1986). Decreased responsiveness of thalidomideexposed lymphocytes to mitogens has also been reported (Roath et al, 1963), but failed to be confirmed (Gunzler et al, 1986). Differences in the parameters under scrutiny, as well as variations in treatment schedules, may account for the discrepancy between previously reported findings and our results.…”
Section: Discussionmentioning
confidence: 97%
“…Thalidomide was found to inhibit lymphocyte proliferation after lectin stimulation in studies relying on optical evaluation of lymphoblast transformation (Roath et al 1962(Roath et al , 1963, but these results could not be reproduced by others (LindahlKiessling & Book 1963). No influence of thalidomide and its 7 major hydrolysis products on the 3H-thymidine incorporation of either lectin-or allogeneically-stimulated peripheral lymphocytes was detected (Gunzler et al 1986).…”
Section: Action Of Thalidomide On the Immune Systemmentioning
confidence: 90%