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Cited by 60 publications
(40 citation statements)
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References 40 publications
(50 reference statements)
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“…Tetracyclines dose-dependently inhibited MMP-9, and IC50 values of 40.0, 10.7, and 608.0 µM were achieved for tetracycline, minocycline, and doxycycline, respectively. In previous studies on different MMPs using alternative experimental models, IC50 values ranging from 5 to 500 µM have been generally reported (13,(23)(24)(25)(26). In a study on collagenase extracted from rabbit corneas, the inhibitory effects of tetracyclines on enzyme activity were measured using a chromogen substrate (27).…”
Section: Discussionmentioning
confidence: 99%
“…Tetracyclines dose-dependently inhibited MMP-9, and IC50 values of 40.0, 10.7, and 608.0 µM were achieved for tetracycline, minocycline, and doxycycline, respectively. In previous studies on different MMPs using alternative experimental models, IC50 values ranging from 5 to 500 µM have been generally reported (13,(23)(24)(25)(26). In a study on collagenase extracted from rabbit corneas, the inhibitory effects of tetracyclines on enzyme activity were measured using a chromogen substrate (27).…”
Section: Discussionmentioning
confidence: 99%
“…Conversion of plasminogen to plasmin by PAs in alginate samples and cell lysates was recorded by the hydrolysis of the chromogenic substrate H-D-Val-Leu-Lys-pNA (S-2251, Chromogenix, Mölndal, Sweden), as has been described [21]. No activity could be detected in media samples.…”
Section: Determination Of Pa Activitymentioning
confidence: 99%
“…Clinically, tetracyclines have been used to treat rheumatoid arthritis and various skin disorders, such as inflammatory acne, rosacea, bullous dermatoses, and neutrophilic dermatoses (12,21). The anti-inflammatory activities of tetracyclines include the modulation of lymphocyte activation and neutrophil chemotaxis (6,30), possibly by inhibiting matrix metalloproteinases (20), phospholipase A 2 (19), nitric oxide synthases (2), and/or caspase 1 (33). The ability of tetracyclines to bind Ca 2ϩ and Mg 2ϩ may account for some of those biological activities via the chelation of those cations and their transport into intracellular compartments (34).…”
mentioning
confidence: 99%