1995
DOI: 10.1021/bi00036a031 View full text |Buy / Rent full text
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Abstract: The effect of temperature and various glycerides to modulate the ability of lysolecithin and fatty acid to promote high phospholipase A2 activity was studied using dipalmitoylphosphatidylcholine large unilamellar vesicles as substrate. The length of the lag phase prior to the accumulation of sufficient hydrolysis products (lysolecithin and fatty acid) to support high phospholipase activity was shortest at temperatures near the thermotropic phase transition of the phospholipid substrate. A reduction in the lag … Show more

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“…12). Importantly, these results support the concept that principles learned from biophysical studies with artificial membranes apply to biological systems (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Attempts have been made previously with cultured cells to determine whether changes in membrane order detectable with fluorescent probes might explain the action of Ca 2ϩ to render them vulnerable to sPLA 2 (3,4).…”
Section: Discussionsupporting
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“…12). Importantly, these results support the concept that principles learned from biophysical studies with artificial membranes apply to biological systems (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Attempts have been made previously with cultured cells to determine whether changes in membrane order detectable with fluorescent probes might explain the action of Ca 2ϩ to render them vulnerable to sPLA 2 (3,4).…”
Section: Discussionsupporting
“…For example, small vesicles composed of phosphatidylcholine are immediately hydrolyzed upon addition of sPLA 2 , while larger vesicles are only vulnerable after perturbation of the membrane with contaminants (8,9,14,15,37). Both gross (size and distortion of shape) and fine (surface texture) morphology were scored from micrographs such as those shown in Fig.…”
Section: Resultsmentioning
“…Second, changes in membrane physical properties that promote one or both of these events render the membrane more susceptible to catalysis (8 -10, 14 -17). The properties found to be important for inducing susceptibility can be summarized in two categories: those that promote negative charge at the bilayer surface and those that perturb the interactions among phospholipid molecules (9,10,(13)(14)(15)(16)(17).…”
Section: Discussionmentioning
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