Effects of syndecan‐4 silencing on the extracellular matrix remodeling in anoikis‐resistant endothelial cells
Jessica Oyie Sousa Onyeisi,
Helena Bonciani Nader,
Carla Cristina Lopes
Abstract:Anoikis is a process of programmed cell death induced by the loss of cell/matrix interactions. In previous work, we have shown that the acquisition of anoikis resistance upregulates syndecan‐4 (SDC4) expression in endothelial cells. In addition, SDC4 gene silencing by microRNA interference reverses the transformed phenotype of anoikis‐resistant endothelial cells. Due to this role of SDC4 in regulating the behavior of anoikis‐resistant endothelial cells, we have evaluated that the functional consequences of SDC… Show more
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