Effects of subthalamic nucleus deep brain stimulation on neuronal spiking activity in the substantia nigra pars compacta in a rat model of Parkinson’s disease

The role of neurotransmitter systems in mediating deep brain stimulation effects in Parkinson’s disease

“…Deep brain stimulation has demonstrated alleviation of motor symptoms of PD while decreasing the need for pharmaceutical dopamine treatment, indicating DBS impacts dopaminergic system. In preclinical research, STN-DBS has both local and distant effects on dopaminergic systems ( Meissner et al, 2002 ; Walker et al, 2009 ; He et al, 2014 ; Yamamoto et al, 2014 ; Carcenac et al, 2015 ; Melon et al, 2015 ; Min et al, 2016 ; Nakajima et al, 2017 ; Du et al, 2018 ; Sahai et al, 2020 ). In contrast, clinical results demonstrate local impacts from STN-DBS using electrophysiological and microdialysis, but such data shows less consistency compared to distant effect from neuroimaging studies ( Hilker et al, 2003 ; Strafella et al, 2003 ; Nimura et al, 2005 ; Hesse et al, 2008 ; Thobois et al, 2010 ; Yamamoto et al, 2015 ).…”

“…Nigrostriatal dopaminergic neurons were assessed in several preclinical animal studies and showed that STN-DBS modulate SNc dopaminergic neurons. Sahai et al (2020) showed that STN-DBS decreases the spiking activity in less than half (43%) of the SNc dopaminergic neurons in naïve rats group while increasing the spiking activity in the other 43% of the cells. However, the PD rat group showed a significant reduction in the spiking activity of 88% of dopaminergic cells ( Sahai et al, 2020 ).…”

“… Sahai et al (2020) showed that STN-DBS decreases the spiking activity in less than half (43%) of the SNc dopaminergic neurons in naïve rats group while increasing the spiking activity in the other 43% of the cells. However, the PD rat group showed a significant reduction in the spiking activity of 88% of dopaminergic cells ( Sahai et al, 2020 ). Moreover, an in vivo microdialysis study on unilateral 6-OHDA rats showed short-term effects of stimulation and lesioning in the STN increased extracellular levels of dopamine in the striatum ( Walker et al, 2009 ).…”

Wireless Stimulation of the Subthalamic Nucleus with Nanoparticles Modulates Key Monoaminergic Systems Similar to Contemporary Deep Brain Stimulation

“…Experimental data has shown that STN-DBS decreases the spiking activity in less than half (43%) of the SNc dopaminergic neurons in naïve rats, while increases the spiking activity in another 43% of the dopaminergic cells [22]. However, the effect of STN-DBS was more consistent in PD animals with decreasing spiking activities in 88% of SNc neurons [22]. Another experiment shows that STN-DBS increases the firing rate of 76% of SNc dopaminergic neurons in naïve animals [23].…”

“…The effect of STN-DBS on neuronal activities of dopaminergic SNc neurons has been investigated in several electrophysiological studies in naïve animals [22,23]. Experimental data has shown that STN-DBS decreases the spiking activity in less than half (43%) of the SNc dopaminergic neurons in naïve rats, while increases the spiking activity in another 43% of the dopaminergic cells [22]. However, the effect of STN-DBS was more consistent in PD animals with decreasing spiking activities in 88% of SNc neurons [22].…”