The research aims to develop learning media based on Information and Communications Technology (ICT) to improve the effectiveness of applying the Direct Instruction method in learning Mathematics in senior high schools in Indonesia. The designed media were modified from the Borg & Gall's Research and Development consisting of 5 steps, namely: (1) exploration studies, (2) initial product development, (3) expert validation and product revision, (4) limited field trials and product revisions, and (5) main field and final product trials. The research was started from a needs analysis of mathematics teachers to determine the subject matter, the material scope, the depth of material, the most familiar software used by teachers, and the availability of cameras. The validation was done by senior high school math teachers. The designed media covered three mathematics units, i.e. Functions, Polynomials, and Quadratic Inequality by combining the handouts and Microsoft powerpoint software. The research found that the Interactive Learning Media was validly used in learning mathematics among the senior high school involved in the recent study. There is improvement on effectiveness of applying the Interactive Learning Media in learning Mathematics. The media allowed the teachers to combine with the handouts and the powerpoint application to obtain result optimally.