Effects of statins in primary and secondary prevention for venous thromboembolism events: A meta analysis

Zhu, Hailan; Zheng, Haoxuan; Xu, Tianyu; Liu, Xiong; Sun, Lichang; Pan, Xiong‐Fei; Mai, Weiyi; Cai, Xiaoyan; Huang, Yuli

doi:10.1016/j.vph.2021.106931

Cited by 18 publications

(17 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The knowledge about the risk factors of VTE could be helpful as a piece of prognostic information, but also to eventually target preventive treatment for VTE, since the co-existence of invasive breast cancer and VTE has a significant impact on survival. In particular, new evidence suggests, in humans, a beneficial effect of statins in reducing the risk of breast cancer distant metastasis and in reducing the risk of VTE recurrence [ 61 , 62 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Incidence and Risk Factors for Venous Thromboembolism in Female Patients Undergoing Breast Surgery

Londero

Bertozzi

Cedolini

et al. 2022

Cancers

View full text Add to dashboard Cite

Albeit it does not have the highest venous thromboembolism (VTE) incidence compared to other neoplasms, breast cancer contributes to many VTE events because it is the most diagnosed tumor in women. We aim to analyze the occurrence and timing of VTE during the follow-up of patients who underwent breast surgery, the possible correlated factors, and the overall survival. This retrospective study included all female patients diagnosed with mammary pathology and surgically treated in our clinic between January 2002 and January 2012. Of 5039 women who underwent breast surgery, 1056 were found to have no evidence of malignancy, whereas 3983 were diagnosed with breast cancer. VTE rate resulted significantly higher in patients with invasive breast cancer than in women with benign breast disease or carcinoma in situ. Invasive cancers other than lobular or ductal were associated with a higher VTE rate. In addition, chronic hypertension, high BMI, cancer type, and evidence of metastasis turned out to be the most significant risk factors for VTE in women who underwent breast surgery. Moreover, VTE occurrence significantly impacted survival in invasive breast cancer patients. Compared to women with benign mammary pathology, VTE prevalence in women with breast cancer is significantly higher. The knowledge about the risk factors of VTE could be helpful as prognostic information, but also to eventually target preventive treatment strategies for VTE, as far as the co-existence of invasive breast cancer and VTE has a significantly negative impact on survival.

show abstract

Section: Discussionmentioning

confidence: 99%

Incidence and Risk Factors for Venous Thromboembolism in Female Patients Undergoing Breast Surgery

Londero

Bertozzi

Cedolini

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

“…We evaluated the risk of bias using the Newcastle-Ottawa quality assessment scale for cohort studies and case-control studies ( 29 ). Cohort studies and case-control studies were classified as having low (≥7 stars), moderate (5–6 stars), and high risk of bias (≤4 stars) with an overall quality score of 9 stars ( 30 , 31 ). For cross-sectional studies, we assigned each item of the AHRQ checklist a score of 1 (answered “yes”) or 0 (answered “no” or “unclear”), and summarized scores across items to generate an overall quality score that ranged from 0 to 11.…”

Section: Methodsmentioning

confidence: 99%

The Association Between Diabetes Mellitus and the Risk of Latent Tuberculosis Infection: A Systematic Review and Meta-Analysis

Yan

et al. 2022

Front. Med.

View full text Add to dashboard Cite

BackgroundThe estimated global latent tuberculosis infection (LTBI) burden indicates a large reservoir of population at risk of developing active tuberculosis (TB). Previous studies suggested diabetes mellitus (DM) might associate with LTBI, though still controversial. We aimed to systematically assess the association between DM and LTBI.MethodsWe searched PubMed, Embase, Cochrane Library and Web of Science. Observational studies reporting the number of LTBI and non-LTBI individuals with and without DM were included. Random-effects or fixed-effects models were used to estimate the pooled effect by risk ratios (RRs) and odds ratios (ORs) and its 95% confidence interval (CI), using the original number of participants involved.Results20 studies involving 4,055,082 participants were included. The pooled effect showed a significant association between DM and LTBI (for cohort studies, RR = 1.62, 95% CI: 1.02–2.56; for cross-sectional studies, OR = 1.55, 95% CI: 1.30–1.84). The pooled OR was high in studies with healthcare workers (5.27, 95% CI: 1.52–8.20), refugees (2.88, 95% CI: 1.93–4.29), sample size of 1,000–5,000 (1.99, 95% CI: 1.49–2.66), and male participants accounted for less than 40% (2.28, 95% CI: 1.28–4.06). Prediabetes also associated with LTBI (OR = 1.36, 95% CI: 1.01–1.84).ConclusionThe risk of LTBI was found to be a 60% increase in DM patients, compared with non-DM patients. LTBI screening among DM patients could be of vital importance. More studies are needed to explore appropriate strategies for targeted LTBI screening among DM patients.

show abstract

“…Numerous studies have demonstrated that statins can reduce the VTE incidence in high risk patients, as well as recurrent VTE and mortality in patients with a previous VTE. 26 , 27 Glynn et al, 28 in their meta‐analysis, mentioned that 20 mg daily rosuvastatin, significantly reduced the rate of VTE recurrence, indicating antiplatelet properties of rosuvastatin. In a study by Siniscalchi et al, 29 statin consumption with anticoagulants for VTE was associated with a 20% decrease in mortality and there was no difference between different drugs of statin class.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have demonstrated that statins can reduce the VTE incidence in high risk patients, as well as recurrent VTE and mortality in patients with a previous VTE 26,27 . Glynn et al, 28 in their meta‐analysis, mentioned that 20 mg daily rosuvastatin, significantly reduced the rate of VTE recurrence, indicating antiplatelet properties of rosuvastatin.…”

Section: Discussionmentioning

confidence: 99%

Significant decrease in plasmad‐dimer levels and mean platelet volume after a 3‐month treatment with rosuvastatin in patients with venous thromboembolism

Alirezaei

Sattari

Irilouzadian

2022

Clinical Cardiology

View full text Add to dashboard Cite

Background Inflammation has been considered as a possible mechanism for the initiation and recurrence of venous thromboembolism (VTE). Statins have anti‐inflammatory and potential immune‐modulatory effects, but their effect on plasma d ‐dimer levels is controversial. Hypothesis In this study, we aimed to evaluate the impact of rosuvastatin on D‐dimer and other inflammatory serum markers in VTE patients. Methods We conducted a prospective, randomized study on 228 patients with VTE. Control group received conventional treatment (warfarin or rivaroxaban), whereas rosuvastatin‐intervention group received rosuvastatin 10 mg daily, in addition to their conventional treatment for 3 months. Serum markers were extracted from both groups at the baseline and 3 months after the beginning of treatment. Results After 3 months, in patients of the intervention group, there was a statistically significant decrease in levels of d ‐dimer and mean platelet volume (MPV) but no significant change in neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio. Conclusions Our results showed that a 3‐month treatment with 10 mg rosuvastatin daily can significantly decrease the plasma levels of d ‐dimer and MPV, which would support a potential role of statins to reduce activated systemic inflammation among VTE patients. Such effects can be used to reduce the rate of recurrent VTE in these patients.

show abstract

Effects of statins in primary and secondary prevention for venous thromboembolism events: A meta analysis

Cited by 18 publications

References 35 publications

Incidence and Risk Factors for Venous Thromboembolism in Female Patients Undergoing Breast Surgery

Incidence and Risk Factors for Venous Thromboembolism in Female Patients Undergoing Breast Surgery

The Association Between Diabetes Mellitus and the Risk of Latent Tuberculosis Infection: A Systematic Review and Meta-Analysis

Significant decrease in plasmad‐dimer levels and mean platelet volume after a 3‐month treatment with rosuvastatin in patients with venous thromboembolism

Contact Info

Product

Resources

About