Effects of spirulina on the number of ovary mast cells in lead‐induced toxicity in rats

Abstract

The present study investigated the protective effect of Spirulina against the lead-induced increase in mast cells in the ovary during the oestrous cycle of rats. In the ovary cortex and medulla of lead-exposed animals, there was a significant increase in the number of mast cells; however, when also treated with Spirulina, a decrease was observed. The number of mast cells when Spirulina (300 mg/kg) was used alone was not significantly different from that of the control group. These results indicate that Spirulina decreases the number of mast cells induced by lead in the cortex and medulla of rat ovary.

Mast cells as novel mediators of reproductive processes

“…Additionally, the recipients were treated with steroids and MCs are known for their susceptibility to the action of hormones like estradiol and progesterone (Wordinger et al, 1985; Cocchiara et al, 1992; Rudolph et al, 2004; Jensen et al, 2010) which probably induced the expansion of the MCs present in the ovaries and their migration to the uterus. We detected high amounts of MCs within the ovaries (unpublished observations) that coincides with observations done in different species like mouse (Skalko et al, 1968), rat (Jones et al, 1980; Gaytan et al, 1991; Aydin et al, 1998; Batth and Parshad, 2000), hamster (Shinohara et al, 1987; Krishna and Terranova, 1991), cow (Reibiger and Spanel-Borowski, 2000), goat (Karaca and Simşek, 2007; Karaca et al, 2008), and chicken (Parshad and Kathpalia, 1993). Furthermore, we could not find alterations in the number of follicles as well as corpora lutea between MC-deficient W-sh and control mice (Woidacki et al, 2013).…”

Effects of Spirulina on Cyclophosphamide-Induced Ovarian Toxicity in Rats: Biochemical and Histomorphometric Evaluation of the Ovary

“…Spirulina (Sp), a blue-green algae, has been demonstrated as an antioxidant and antiapoptotic in many in vitro and in vivo studies [12]. Its protective effects on the rat ovary against lead-induced [13] and Cyc-induced toxicities has been published [14]. However, no reports are available on the biochemical effects of Cyc on the ovary or the possible protective effects of Sp on ovarian histomorphometry and oxidant status in Cyc-exposed ovaries.…”

Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals

“…However, no significant changes in Pb levels were observed in the liver, lung, heart and kidneys of the two animal groups. The administration of 300 mg/kg of Spirulina was also able to diminish the increase in the number of mast cells due to Pb in the cortex and medulla of adult inbred female Wistar albino rat ovaries during the oestrous cycle [128]. Ponce-Canchihuamán et al ( 2010) [129] demonstrated that Spirulina restored the biochemical parameters of the liver and kidneys in old Wistar male rats, decreasing the lipid levels both in plasma and liver as well as lipid peroxidation in the liver and kidneys.…”