Effects of silicone gel on burn scars

Momeni, Maryam; Hafezi, Farhad; Rahbar, Hossein; Karimi, Hamid

doi:10.1016/j.burns.2008.04.011

Cited by 72 publications

(68 citation statements)

References 20 publications

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“…Since these early studies, 1,30,31 the subject of scar therapy has advanced dramatically along with clinical evidence, commercial engagement, and consumer interest. [32][33][34][35][36] This progression has been driven by the ongoing clinical support which continues to raise interest and awareness of the efficacy of SGS in scar management in comparison to the alternatives. 32,37,38 In fact, it is proposed that topical SGS and intralesional steroids are the only evidence-based recommendable forms of treatment to control the quality of a scar.…”

Section: Advantages Of Sgsmentioning

confidence: 99%

The Use of Silicone Adhesives for Scar Reduction

Bleasdale¹,

Finnegan

Murray

et al. 2015

Advances in Wound Care

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Significance: This article discusses the history and developments of silicone gel sheeting (SGS) scar therapy. Furthermore, we review a breadth of literature to gain an insight into how and why topical silicone gels remain the favored treatment of medical experts in scar management. We also analyze an ever increasing number of alternative therapies claiming to provide enhanced scar reduction performance. Recent Advances: Topical silicone gel treatments seem to remain the first point of clinical recommendation in scar management. SGS has been used in scar therapy for over 30 years, during which its efficacy has been the subject of numerous clinical evaluations. Critical Issues: While the exact mechanisms by which SGS improves hypertrophic scars, keloid development and recovery are yet to be fully agreed upon, its ability to do so remains largely undisputed at present. However, there still is ongoing deliberation over the exact mechanism of action of silicone in improving a scar. At present it is likely that through occlusion of the scar site and hydration of the wound bed, the overactivity of scar-related cells is suppressed, and their activity normalized. Future Direction: The clinical support of topical silicone gel products, relative to all alternative scar therapies, is considered the internationally recommended first-line form of scar management, and favored by consensus among healthcare professionals. However, there still remains the need for further clinical evidence and a better understanding of the mechanism behind the benefit of silicone gel for use in the prevention of abnormal scarring. SCOPE AND SIGNIFICANCESilicone gel sheeting (SGS) has been used in scar therapy for over 30 years, during which its efficacy has been the subject of numerous clinical evaluations. While the exact mechanisms by which SGS improves hypertrophic scars, keloid development and recovery are yet to be fully agreed upon, its ability to do so remains largely undisputed. As such, topical silicone gel treatments seem to remain the first point of clinical recommendation in scar management. This article aims to review a breadth of literature to gain an insight not only into how, but also why topical silicone gels remain the favored treatment of medical experts in scar management. We also analyze an ever increasing number of alternative therapies claiming to provide enhanced scar reduction performance as a comparison. TRANSLATIONAL RELEVANCESilicone has been used for more than 30 years in the treatment of cutaneous scars.1 New formulations and formats of silicone gel products are becoming available for use in the treatment of scarring resulting from surgery, burns, and other skin injuries requiring hospital treatment.

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Section: Advantages Of Sgsmentioning

confidence: 99%

The Use of Silicone Adhesives for Scar Reduction

Bleasdale¹,

Finnegan

Murray

et al. 2015

Advances in Wound Care

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“…gels, sheets and tapes) are the preferred preventative measure. [8][9][10] Such products should be applied after epithelisation is established and used for at least a month to maximise results. Silicone sheets are commonly available and should be applied for at least 12 hours per day.…”

Section: Scar Preventionmentioning

confidence: 99%

“…Silicone gels, creams and ointments are acceptable alternatives for face and neck scars as well as for patients in hot or humid climates. [9][10][11] Intralesional corticosteroid injections are considered second-line approaches in scar prevention. 12,13 However, silicone and intralesional steroid injections should be used synergistically in high-risk patients.…”

Section: Scar Preventionmentioning

confidence: 99%

“…The exact pathophysiology of scar formation has yet to be completely elucidated, although several factors are believed to play a role, including the degree of tension across the edges of the wound and the speed of cell growth. 9,10 Variable systems exist to quantify changes in scar appearance and there is also a lack of theoretical models available to evaluate current therapies. This has led to a limited amount of useful data derived from prospective randomised studies.…”

Section: Scar Managementmentioning

confidence: 99%

“…8,18,19 Success rates are improved if the sheets or gels are applied for at least 12 hours every day for a minimum of two months. 9,19 If the patient has severe scarring, then augmentation of therapy using intralesional corticosteroid injections or 5-fluorouracil (5-FU) is indicated. 12,13,20,21 It is important to note that hyperpigmentation and skin irritation at the injection site are well-known sideeffects of 5-FU therapy.…”

Section: Linear Hypertrophic Scarsmentioning

confidence: 99%

See 2 more Smart Citations

Cutaneous Scar Prevention and Management: Overview of current therapies

Al-Shaqsi¹,

Al-Bulushi²

2016

SQUMJ

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Cutaneous scarring is common after trauma, surgery and infection and occurs when normal skin tissue is replaced by fibroblastic tissue during the healing process. The pathophysiology of scar formation is not yet fully understood, although the degree of tension across the wound edges and the speed of cell growth are believed to play central roles. Prevention of scars is essential and can be achieved by attention to surgical techniques and the use of measures to reduce cell growth. Grading and classifying scars is important to determine available treatment strategies. This article presents an overview of the current therapies available for the prevention and treatment of scars. It is intended to be a practical guide for surgeons and other health professionals involved with and interested in scar management.

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Silicone gel sheeting for preventing and treating hypertrophic and keloid scars

O’Brien

Jones

2013

Cochrane Database of Systematic Reviews

156

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There is weak evidence of a benefit of silicone gel sheeting as a prevention for abnormal scarring in high-risk individuals but the poor quality of research means a great deal of uncertainty prevails. Trials evaluating silicone gel sheeting as a treatment for hypertrophic and keloid scarring showed improvements in scar thickness and scar colour but are of poor quality and highly susceptible to bias.

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Effects of silicone gel on burn scars

Cited by 72 publications

References 20 publications

The Use of Silicone Adhesives for Scar Reduction

The Use of Silicone Adhesives for Scar Reduction

Cutaneous Scar Prevention and Management: Overview of current therapies

Silicone gel sheeting for preventing and treating hypertrophic and keloid scars

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