Effects of short-term treatment with vitamin E in systemic sclerosis: a double blind, randomized, controlled clinical trial of efficacy based on urinary isoprostane measurement

Cracowski, Jean‐Luc; Girolet, Stéphanie; Imbert, B.; Seinturier, C.; Stanke‐Labesque, Françoise; Bessard, Janine; Boignard, Aude; Bessard, Germain; Carpentier, Patrick

doi:10.1016/j.freeradbiomed.2004.09.032

Cited by 35 publications

(25 citation statements)

References 13 publications

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“…The remaining 278 references could be utilized to establish the increase in 8-iso-PGF 2α levels associated with medical conditions [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146]…”

Section: Resultsmentioning

confidence: 99%

Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin F2α

Erve

2018

Redox Biology

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The widespread detection of elevated oxidative stress levels in many medical conditions has led to numerous efforts to design interventions to reduce its effects. Efforts have been wide-ranging, from dietary changes to administration of antioxidants, supplements, e.g., omega-3-fatty acids, and many medications. However, there is still no systemic assessment of the efficacy of treatments for oxidative stress reduction across a variety of medical conditions.The goal of this meta-analysis is, by combining multiple studies, to quantitate the change in the levels of the popular oxidative stress biomarker 8-iso-prostaglandin F2α (8-iso-PGF2α) after a variety of treatment strategies in human populations.Nearly 350 unique publications with 180 distinct strategies were included in the analysis. For each strategy, the difference between pre- or placebo and post-treatment levels calculated using Hedges’ g value of effect. In general, administration of antibiotics, antihyperlipidemic agents, or changes in lifestyle (g = − 0.63, − 0.54, and 0.56) had the largest effect. Administration of supplements, antioxidants, or changes in diet (g = − 0.09, − 0.28, − 0.12) had small quantitative effects. To fully interpret the effectiveness of these treatments, comparisons to the increase in g value for each medical condition is required. For example, antioxidants in populations with coronary artery disease (CAD) reduce the 8-iso-PGF2α levels by g = − 0.34 ± 0.1, which is quantitatively considered a small effect. However, CAD populations, in comparison to healthy populations, have an increase in 8-iso-PGF2α levels by g = 0.38 ± 0.04; therefore, the overall reduction of 8-iso-PGF2α levels is ≈ 90% by this treatment in this specific medical condition.In conclusion, 8-iso-PGF2α levels can be reduced not only by antioxidants but by many other strategies. Not all strategies are equally effective at reducing 8-iso-PGF2α levels. In addition, the effectiveness of any strategy can be assessed only in relation to the medical condition investigated.

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Section: Resultsmentioning

confidence: 99%

Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin F2α

Erve

2018

Redox Biology

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“…The authors suggest that this activity could probably have a role in the maintenance of intracellular calcium homeostasis. However, in SSc patients, 3 weeks of treatment with vitamin E at doses of 500 or 1000 mg/day neither decreases the basal rate of lipid peroxidation nor improves microvascular perfusion after cold exposure (30). Similarly, the results of five randomized clinical trials of vitamin E supplementation in patients with RA offered little convincing evidence of a positive effect (21).…”

Section: Antioxidant and Autoimmunitymentioning

confidence: 99%

Relationship Between Redox Status and Cell Fate in Immunity and Autoimmunity

Ortona

Maselli²,

Delunardo³

et al. 2014

Antioxidants & Redox Signaling

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“…For example, a short-term treatment with vitamin E in SSc patients failed to decrease the basal rate of lipid peroxidation and did not improve microvascular perfusion following cold exposure in these patients [ 67 ] . However, in related studies, Allanore et al found acute and sustained effects of dihydropyridine-type calcium-channel antagonists on oxidative stress in SSc [ 68 ] , and nifedipine, one of the most commonly used dihydropyridine-type calcium-channel antagonist, was found to protect against overproduction of superoxide anion by peripheral blood monocytes from SSc patients.…”

Section: Antioxidant Treatmentsmentioning

confidence: 97%

Role of Oxidative Stress and Reactive Oxygen Radicals in the Pathogenesis of Systemic Sclerosis

Piera-Velázquez

Jimenez

2012

Studies on Arthritis and Joint Disorders

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Systemic sclerosis (SSc) is an autoimmune connective tissue disease which causes progressive fi brosis of skin and numerous internal organs. Although the etiology of SSc is unknown and the detailed mechanisms responsible for the fi brotic process have not been elucidated, there is strong evidence to support the concept that oxidative stress mediated by an excessive generation of oxidative free radicals plays a crucial role. Elevated levels of markers of oxidative stress and reduced levels of antioxidants have been found in SSc patients, and the most commonly studied animal models of SSc are induced by chemical agents that generate oxidative stress. In this chapter, the available evidence for the participation of oxidative stress in SSc pathogenesis will be reviewed emphasizing the link between free radicals and the process of fi brosis and the potentially bene fi cial effects of antioxidant treatment for the disease.

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Effects of short-term treatment with vitamin E in systemic sclerosis: a double blind, randomized, controlled clinical trial of efficacy based on urinary isoprostane measurement

Cited by 35 publications

References 13 publications

Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin F2α

Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin F2α

Relationship Between Redox Status and Cell Fate in Immunity and Autoimmunity

Role of Oxidative Stress and Reactive Oxygen Radicals in the Pathogenesis of Systemic Sclerosis

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