Effects of short-term fasting on cancer treatment

Groot, Stefanie de; Pijl, Hanno; Hoeven, J.J.M. van der; Kroep, Judith R.

doi:10.1186/s13046-019-1189-9

Cited by 88 publications

(86 citation statements)

References 141 publications

(139 reference statements)

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“…Similarly to de Groot et al 9, we found a significant reduction of IGF-1 during mSTF. This reduction of IGF-1 seems to be one of the key mediators of differential stress resistance in response to nutrient restriction (36) healthy adults (38). While de Groot et al (9) revealed no change of fT3, we found a significant reduction of fT3 during KD in our previous trial in healthy subjects (38).…”

Section: Discussionsupporting

confidence: 42%

Impact of modified short-term fasting and the combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients – a randomised controlled cross-over pilot study

Zorn

Ehret

Schäuble

et al. 2020

Preprint

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Background This pilot trial aimed to investigate whether modified short-term fasting (mSTF) reduces the incidence of chemotherapy-induced toxicities and whether an initial ketogenic diet (KD) as fasting supportive diet reduces the fasting-related discomfort and increases the compliance. Methods In this randomised controlled cross-over trial, gynaecologic cancer patients receiving chemotherapy with a minimum of 4 cycles were randomised to mSTF for 96 h during half of chemotherapy cycles and to consume a normocaloric diet during the other chemotherapy cycles. The caloric intake during mSTF was restricted to 25% of each patient's daily requirement. In addition, half of the patients should eat a 6-day normocaloric KD prior to each mSTF period to investigate the hunger-suppression effect of a KD. Chemotherapy-induced toxicities, fasting-related discomfort, body composition, quality of life, laboratory values, and compliance were assessed on each chemotherapy. Results Thirty patients (30-74 years) completed the study. During mSTF frequency and severity scores of stomatitis [-0.16 ± 0.06; 95% CI -0.28 - (-0.03); P = 0.013], headaches [-1.80 ± 0.55; 95% CI -2.89 – (-0.71); P = 0.002], weakness [-1.99 ± 0.87; 95% CI -3.72 – (-0.26); P = 0.024] and the score of total toxicities were significantly reduced [-10.36 ± 4.44; 95% CI -19.22 - (-1.50); P = 0.023]. Additionally, significant fewer postponements of the chemotherapy were observed post-mSTF, reflecting an improved tolerance of chemotherapy [-0.80 ± 0.37; 95% CI -1.53 – (-0.06); P = 0.034]. A significant reduction of mean body weight by -0.79 ± 1.47 kg during mSTF could not be compensated and remained until the end of study ( P <0.005). On average, Insulin [-169.4 ± 44.1; 95% CI -257.1 – (-81.8); P <0.001] and Insulin-like growth factor 1 levels [-33.3 ± 5.4; 95% CI -44.1 – (-22.5); P <0.001] significantly decreased during fasting. The KD as fasting supportive diet could neither reduce fasting-related discomfort nor increase compliance of our fasting regime. Conclusion MSTF is safe and feasible in gynaecologic cancer patients. The results indicate that mSTF during chemotherapy can reduce chemotherapy-induced toxicities and increase the tolerance of chemotherapy. Larger clinical trials are required to recommend mSTF for cancer patients.

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Section: Discussionsupporting

confidence: 42%

Impact of modified short-term fasting and the combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients – a randomised controlled cross-over pilot study

Zorn

Ehret

Schäuble

et al. 2020

Preprint

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“…There is growing evidence that short-term fasting can improve patient response to cancer chemotherapy, whilst providing protection from toxicity [28].…”

Section: Metabolic Effects Of Controlled and Ramadan Fastingmentioning

confidence: 99%

Ramadan and Diabetes: A Narrative Review and Practice Update

et al. 2020

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Fasting in the Islamic month of Ramadan is obligatory for all sane, healthy adult Muslims. The length of the day varies significantly in temperate regions-typically lasting C 18 h during peak summer in the UK. The synodic nature of the Islamic calendar means that Ramadan migrates across all four seasons over an approximately 33-year cycle. Despite valid exemptions, there is an intense desire to fast during this month, even among those who are considered to be at high risk, including many individuals with diabetes mellitus. In this review we explore the current scientific and clinical evidence on fasting in patients with diabetes mellitus, focussing on type 2 diabetes mellitus and type 1 diabetes mellitus, with brief reviews on pregnancy, pancreatic diabetes, bariatric surgery, the elderly population and current practice guidelines. We also make recommendations on the management of diabetes patients during the month of Ramadan.

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“…La evidencia muestra que el ayuno protege de la toxicidad al tiempo que mejora la eficacia de una variedad de quimioterapéuticos en el tratamiento de varios tipos de tumores (23) .…”

Section: Cáncerunclassified

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Canicoba

2020

Rev. Nutr. Clin. Metab.

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Effects of short-term fasting on cancer treatment

Cited by 88 publications

References 141 publications

Impact of modified short-term fasting and the combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients – a randomised controlled cross-over pilot study

Impact of modified short-term fasting and the combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients – a randomised controlled cross-over pilot study

Ramadan and Diabetes: A Narrative Review and Practice Update

Aplicaciones clínicas del ayuno intermitente

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