2018
DOI: 10.18632/aging.101624
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Abstract: Regenerative medicine approaches based on mesenchymal stem cells (MSCs) are being investigated to treat several aging-associated diseases, including age-related macular degeneration (AMD). Loss of retinal pigment epithelium (RPE) cells occurs early in AMD, and their transplant has the potential to slow disease progression.The human RPE contains a subpopulation of cells - adult RPE stem cells (RPESCs) – that are capable of self-renewal and of differentiating into RPE cells in vitro. However, age-related MSC cha… Show more

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Cited by 9 publications
(2 citation statements)
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References 56 publications
(63 reference statements)
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“…MMPs and their inhibitors play a role in the pathogenesis of AMD [ 108 ] [ 109 , 110 ] by reorganizing the extracellular matrix [ 111 ] and reduction in the build up of sub-RPE material [ 58 ]. CDKN1A is involved in RPE differentiation, proliferation, migration, and cell-cycle progression [ 112 ]. As such, CDKN1A plays a role in the ageing process of RPE and hence in AMD [ 113 ].…”
Section: Discussionmentioning
confidence: 99%
“…MMPs and their inhibitors play a role in the pathogenesis of AMD [ 108 ] [ 109 , 110 ] by reorganizing the extracellular matrix [ 111 ] and reduction in the build up of sub-RPE material [ 58 ]. CDKN1A is involved in RPE differentiation, proliferation, migration, and cell-cycle progression [ 112 ]. As such, CDKN1A plays a role in the ageing process of RPE and hence in AMD [ 113 ].…”
Section: Discussionmentioning
confidence: 99%
“…A main feature of SASP is the presence of cytokines and chemokines whose expression is regulated by NF-κB [ 47 ]. In our experimental model, the long-term exposure to H 2 O 2 increased the expression of the inflammatory cytokines IL-6 and IL-1β thus suggesting the acquisition of SASP, which could also affect other retinal cells during pathogenesis and progression of AMD [ 9 , 48 ]. Moreover, the increase in pro-inflammatory mediators upon senescence induction may mirror inflammaging, a state of low-grade chronic inflammation induced by age-related mitochondrial dysfunction that is deeply connected to age-relate pathologies including AMD [ 49 , 50 ].…”
Section: Discussionmentioning
confidence: 99%