volume 10, issue 1, P100-114 2018
DOI: 10.18632/aging.101362
View full text
Ruohan Sun, Tongrong He, Yujun Pan, Zvonimir S. Katusic

Abstract: ABSTRACTThe present study was designed to determine the effects of senescence and angiotensin II (Ang II) on expression and processing of amyloid precursor protein (APP) in human brain microvascular endothelial cells (BMECs). Senescence caused a decrease in APP expression thereby resulting in reduced secretion of soluble APPα (sAPPα). In contrast, β-site APP cleaving enzyme (BACE1) expression and production of amyloid β (Aβ)40 were increased in senescent endothelium. Importantly, in senescent human BMECs, tre…

expand abstract