Effects of selected secondary metabolites of Fusarium moniliforme on unscheduled synthesis of DNA by rat primary hepatocytes

Evaluation of the genotoxicity of Fusarium mycotoxin moniliformin in human peripheral blood lymphocytes

“…DOI 10.1002/em The mutagenicity of MON has been reported in several different cell lines. Negative results have been obtained using other test systems [Ueno and Kubota, 1976;Wehner et al, 1978;Auffray and Boutibonnes, 1986;Norred et al, 1992]. Styer and Cutler [1984] reported that high concentrations of MON caused a disruption of the spindle apparatus and consequent C-mitosis, and metaphase accumulation in Zea mays.…”

Evaluation of the genotoxicity of Fusarium mycotoxin moniliformin in human peripheral blood lymphocytes

“…DOI 10.1002/em The mutagenicity of MON has been reported in several different cell lines. Negative results have been obtained using other test systems [Ueno and Kubota, 1976;Wehner et al, 1978;Auffray and Boutibonnes, 1986;Norred et al, 1992]. Styer and Cutler [1984] reported that high concentrations of MON caused a disruption of the spindle apparatus and consequent C-mitosis, and metaphase accumulation in Zea mays.…”

Apoptotic and anti-proliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells

“…Previous studies have characterized fumonisin B] as both a tumor initiator (5) and a tumor promoter in rodents (6) and as a mitogen based on its ability to stimulate [ 3 H]thymidine incorporation in Swiss 3T3 murine fibroblasts (7). However, other studies have demonstrated that fumonisin Bj is not a mutagen in Salmonella mutagenicity assays (8) and does not induce unscheduled DNA synthesis in rat primary hepatocytes in culture (9). These results indicate that fumonisin B] is not a genotoxic tumor initiator.…”

Role of fumonisin B1 on DNA methylation changes in rat kidney and liver cells

“…Global methylation status was quantified by HPLC-UV/DAD. (Norred et al, 1992) and appears not to bind directly to DNA. Epigenetic alterations may play an important role in the mechanism of FB1 carcinogenicity (Gelderblom & Marasas, 2012).…”

Evaluation of the genotoxicity of Fusarium mycotoxin moniliformin in human peripheral blood lymphocytes

“…DOI 10.1002/em The mutagenicity of MON has been reported in several different cell lines. Negative results have been obtained using other test systems [Ueno and Kubota, 1976;Wehner et al, 1978;Auffray and Boutibonnes, 1986;Norred et al, 1992]. Styer and Cutler [1984] reported that high concentrations of MON caused a disruption of the spindle apparatus and consequent C-mitosis, and metaphase accumulation in Zea mays.…”

Apoptotic and anti-proliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells

“…Previous studies have characterized fumonisin B] as both a tumor initiator (5) and a tumor promoter in rodents (6) and as a mitogen based on its ability to stimulate [ 3 H]thymidine incorporation in Swiss 3T3 murine fibroblasts (7). However, other studies have demonstrated that fumonisin Bj is not a mutagen in Salmonella mutagenicity assays (8) and does not induce unscheduled DNA synthesis in rat primary hepatocytes in culture (9). These results indicate that fumonisin B] is not a genotoxic tumor initiator.…”

Role of fumonisin B1 on DNA methylation changes in rat kidney and liver cells

“…Global methylation status was quantified by HPLC-UV/DAD. (Norred et al, 1992) and appears not to bind directly to DNA. Epigenetic alterations may play an important role in the mechanism of FB1 carcinogenicity (Gelderblom & Marasas, 2012).…”

Evaluation of the genotoxicity of Fusarium mycotoxin moniliformin in human peripheral blood lymphocytes

“…DOI 10.1002/em The mutagenicity of MON has been reported in several different cell lines. Negative results have been obtained using other test systems [Ueno and Kubota, 1976;Wehner et al, 1978;Auffray and Boutibonnes, 1986;Norred et al, 1992]. Styer and Cutler [1984] reported that high concentrations of MON caused a disruption of the spindle apparatus and consequent C-mitosis, and metaphase accumulation in Zea mays.…”

Apoptotic and anti-proliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells

“…Previous studies have characterized fumonisin B] as both a tumor initiator (5) and a tumor promoter in rodents (6) and as a mitogen based on its ability to stimulate [ 3 H]thymidine incorporation in Swiss 3T3 murine fibroblasts (7). However, other studies have demonstrated that fumonisin Bj is not a mutagen in Salmonella mutagenicity assays (8) and does not induce unscheduled DNA synthesis in rat primary hepatocytes in culture (9). These results indicate that fumonisin B] is not a genotoxic tumor initiator.…”

Role of fumonisin B1 on DNA methylation changes in rat kidney and liver cells

“…Global methylation status was quantified by HPLC-UV/DAD. (Norred et al, 1992) and appears not to bind directly to DNA. Epigenetic alterations may play an important role in the mechanism of FB1 carcinogenicity (Gelderblom & Marasas, 2012).…”