2020
DOI: 10.1002/ptr.6708
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Abstract: The aim of this systematic review and meta-analysis was to evaluate the effects of Nigella sativa (N. sativa) on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress. Two independent authors systematically examined online databases consisting of, EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science from inception until October 30, 2019. Cochrane Collaboration risk of bias tool was applied to assess the methodological quality of the studied trials. The heterogeneity amon… Show more

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Cited by 25 publications
(42 citation statements)
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“…Nigella sativa (NS) is a herbal medicine used in various studies as an alternative medication alongside their chemical counterparts. Several findings suggest that NS oil, obtained from its seeds, maybe a beneficial dietary supplement in preventing and managing various disorders by exerting antioxidative or anti‐inflammatory effects (Ardiana, Pikir, Santoso, Hermawan, & Al‐Farabi, 2020; Hallajzadeh et al, 2020; Tavakoly et al, 2019). It is also indicated that NS might be a suitable choice in managing most of the metabolic parameters, including glycemic homeostasis, lipid profile (Askari et al, 2019; Daryabeygi‐Khotbehsara, Golzarand, Ghaffari, & Djafarian, 2017; Sahebkar, Beccuti, Simental‐Mendía, Nobili, & Bo, 2016), and blood pressure (BP) (Sahebkar, Soranna, et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…Nigella sativa (NS) is a herbal medicine used in various studies as an alternative medication alongside their chemical counterparts. Several findings suggest that NS oil, obtained from its seeds, maybe a beneficial dietary supplement in preventing and managing various disorders by exerting antioxidative or anti‐inflammatory effects (Ardiana, Pikir, Santoso, Hermawan, & Al‐Farabi, 2020; Hallajzadeh et al, 2020; Tavakoly et al, 2019). It is also indicated that NS might be a suitable choice in managing most of the metabolic parameters, including glycemic homeostasis, lipid profile (Askari et al, 2019; Daryabeygi‐Khotbehsara, Golzarand, Ghaffari, & Djafarian, 2017; Sahebkar, Beccuti, Simental‐Mendía, Nobili, & Bo, 2016), and blood pressure (BP) (Sahebkar, Soranna, et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…Studies suggest a bene cial effect of N. sativa supplementation on glycemic status, especially fasting blood glucose and HbA1c [24,28]. Also, a hypolipidemic effect of N. sativa was shown by reducing verylow-density lipoprotein, triglyceride, total cholesterol, and low-density lipoprotein level [28,40,41].…”
Section: Discussionmentioning
confidence: 99%
“…Numerous studies have been carried out to evaluate the therapeutic effects of this plant. Improving the components of metabolic syndrome and lipid pro le, lowering blood pressure, alleviating glycemic indexes, as well as reducing in ammation, have been among the properties discovered in recent years [28][29][30][31][32][33][34]. N. sativa is shown to improve the endothelial in ammation and atherosclerosis by reducing the gene expression of Vascular cell adhesion molecule (VCAM-1) and oxidized low-density lipoprotein (LOX-1) in endothelial cell of diabetic rats [35].…”
mentioning
confidence: 99%
“…In addition, many researches have indicated that thymoquinone had various pharmacological activities, proving to be responsible for oil activities. In addition, some clinical trials have been conducted on eligible patients to evaluate the effects of N. sativa seeds on glycemic control, inflammation, oxidative stress, and so on [44]. And, we have summarized the characteristics of several human studies regarding the effect of Nigella sativa seeds in Table 2. 3.1.…”
Section: Pharmacological Effectsmentioning
confidence: 99%