Effects of resveratrol on the inflammatory response and renal injury in hyperuricemic rats

Ben-xi, Xiao; Ma, Wenjun; Zheng, Ying; Li, Zhen; Li, Dan; Zhang, Yanjun; Li, Yuanhong

doi:10.4162/nrp.2021.15.1.26

Cited by 16 publications

(9 citation statements)

References 33 publications

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“…We further explored the mechanism of resveratrol on XO in human HepG2 cells and found that FFA treatment increased uric acid levels in the supernatants and intracellular XO activity, and resveratrol (10 μmol/L) significantly decreased the uric acid and activity of XO. Taken together, these results suggest that the uric acid-lowering effect of resveratrol can be attributed to a certain extent to decreased uric acid production mediated by decreasing XO activity, consistent with the literature [ 44 , 53 ]. Although the dosage of resveratrol in cell experiment (10 μmol/L) was higher than the physiological concentration reported [ 54 ], it is at a low dose level in previous in vitro studies [ 55 , 56 ].…”

Section: Discussionsupporting

confidence: 92%

“…Regarding the effect of resveratrol on hyperuricemia, animal studies showed that resveratrol reduced serum uric acid concentration by inhibiting XO to reduce uric acid production [ 44 ] and regulating organic ion transporters to increase uric acid excretion [ 45 , 46 ], which are inconsistent with the results of clinical studies. It has been reported that resveratrol dimers significantly reduced uric acid levels in healthy subjects [ 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

“…Resveratrol, as a natural exogenous antioxidant, may decrease the production of uric acid by reducing oxidative stress. In this regard, Xiao et al [ 44 ] showed that resveratrol intervention in hyperuricemia rats reduced serum uric acid and XO and levels of SOD, a traditional oxidative stress biomarker, indicating that oxidative stress was alleviated. In clinical studies, Ali Movahed et al [ 57 ] demonstrated that 500 mg/d resveratrol for 60 days decreased oxidative stress biomarker MDA levels and increased total antioxidant capacity in subjects with type 1 diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

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A Randomized Trial on Resveratrol Supplement Affecting Lipid Profile and Other Metabolic Markers in Subjects with Dyslipidemia

et al. 2023

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Resveratrol is a polyphenol with a well-established beneficial effect on dyslipidemia and hyperuricemia in preclinical experiments. Nonetheless, its efficacy and dose–response relationship in clinical trials remains unclear. This study examined whether resveratrol supplement improves the serum lipid profile and other metabolic markers in a dose-response manner in individuals with dyslipidemia. A total of 168 subjects were randomly assigned to placebo (n = 43) and resveratrol treatment groups of 100 mg/d (n = 41), 300 mg/d (n = 43), and 600 mg/d (n = 41). Anthropometric and biochemical parameters were analyzed at baseline and 4 and 8 weeks. Resveratrol supplementation for 8 weeks did not significantly change the lipid profile compared with the placebo. However, a significant decrease of serum uric acid was observed at 8 weeks in 300 mg/d (−23.60 ± 61.53 μmol/L, p < 0.05) and 600 mg/d resveratrol groups (−24.37 ± 64.24 μmol/L, p < 0.01) compared to placebo (8.19 ± 44.60 μmol/L). Furthermore, xanthine oxidase (XO) activity decreased significantly in the 600 mg/d resveratrol group (−0.09 ± 0.29 U/mL, p < 0.05) compared with placebo (0.03 ± 0.20 U/mL) after 8 weeks. The reduction of uric acid and XO activity exhibited a dose–response relationship (p for trend, <0.05). Furthermore, a marked correlation was found between the changes in uric acid and XO activity in the resveratrol groups (r = 0.254, p < 0.01). Resveratrol (10 μmol/L) treatment to HepG2 cells significantly reduced the uric acid levels and intracellular XO activity. Nevertheless, we failed to detect significant differences in glucose, insulin, or oxidative stress biomarkers between the resveratrol groups and placebo. In conclusion, resveratrol supplementation for 8 weeks had no significant effect on lipid profile but decreased uric acid in a dose-response manner, possibly due to XO inhibition in subjects with dyslipidemia. The trial was registered on ClinicalTrials.gov (NCT04886297).

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Randomized Trial on Resveratrol Supplement Affecting Lipid Profile and Other Metabolic Markers in Subjects with Dyslipidemia

et al. 2023

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“… 2021 ), drug-induced kidney injury (DKI) (Xiao et al. 2021 ) and sepsis-associated acute kidney injury (SA-AKI) (Wang et al. 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The anti-inflammatory activity of resveratrol in acute kidney injury: a systematic review and meta‐analysis of animal studies

Cao

Yang

et al. 2022

Pharmaceutical Biology

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Context Accumulated experimental evidence suggests that resveratrol (RSV) may have an effect on acute kidney injury (AKI) by inhibiting inflammation. However, the credibility of the evidence for this practice is unclear. Objective This study investigated the effect of RSV on AKI and the underlying mechanism. Methods We searched PubMed, EMBASE, and Web of Science from 2005 to April 2022 for controlled animal trials assessing the effect of conventional resveratrol versus placebo on renal function outcome after AKI. This study was registered within the International Prospective Register of Systematic Reviews (PROSPERO) as number CRD42022329596. Results We retrieved 455 studies, 25 studies comprising data of 436 animals that met the inclusion criteria. Our meta-analysis suggested that RSV treatment was significantly associated with lower levels of serum creatinine (Scr) and blood urea nitrogen (BUN). The greatest effects were recorded in low-dose (<20 mg/kg/day) groups rather than in high-dose (> 20 mg/kg/day) groups. For time-response effects, subgroup analysis indicated that intervention duration of RSV can influence the treatment effect, and more beneficial effects were observed when studies had a drug administration time of <2 weeks. Discussion and conclusions This systematic review of animal AKI studies showed a consistently favourable effect of RSV as compared to placebo on renal function outcomes that increased with lower TNF-α, IL-6, and IL-1β. RSV has a more beneficial effect on SA-AKI animal models than the others. When the RSV intervention dose was low (< 20 mg/kg/day) and the intervention time was <2 weeks, more benefits could be observed.

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“…In the same context, the renoprotective effect of resveratrol appears via activation of the SIRT1/FOXO1 pathway and enhances mitochondrial biogenesis with Mn-SOD. Moreover, it prevents glomerulosclerosis, and attenuated renotoxicity-induced by lipopolysaccharides may be via reduced SIRT3 activity (33)(34)(35)(36)(37)(38).…”

Section: Discussionmentioning

confidence: 99%

Renal ameliorating effect of resveratrol in hydrogen peroxide induced male rats

Khudair

Al-Okaily

2022

IJVS

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The study aimed to investigate the potential effect of resveratrol (RS) supplementation in attenuating kidney injury induced by hydrogen peroxide (H2O2) in male rats. Forty adult male rats were randomly assigned into four groups (10 each). The control group was orally supplemented with distilled water, and group G1 was orally supplemented with tap water containing 0.5% of H2O2, G2: was orally supplemented with tap water containing 0.5% of H2O2 and RS 87 mg/kg BW, and G3 was orally supplemented with RS 87 mg/kg BW. Blood samples were obtained before treatment and after 45 days of daily treatment. Serum concentrations of creatinine (Cr), urea nitrogen (UN), and total bilirubin were assessed. On day 45, male rats were euthanized, and kidney samples were taken to estimate malondialdehyde (MDA) and superoxide dismutase (SOD) concentrations, and other samples were obtained for histopathological examination. The results showed a significant increase in creatinine and BUN concentrations accompanied by a significant increase in MDA and a decrease in SOD in kidney tissue in G1 group male rats compared to other groups. Resveratrol partially restored the studied criteria related to renal functions by modulating the histopathological changes in the kidney induced by hydrogen peroxide. It could be concluded that supplementation of resveratrol to oxidatively stressed rats maintains the antioxidant defenses mechanism and could be helpful in the prevention of renal oxidative stress.

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Effects of resveratrol on the inflammatory response and renal injury in hyperuricemic rats

Cited by 16 publications

References 33 publications

A Randomized Trial on Resveratrol Supplement Affecting Lipid Profile and Other Metabolic Markers in Subjects with Dyslipidemia

A Randomized Trial on Resveratrol Supplement Affecting Lipid Profile and Other Metabolic Markers in Subjects with Dyslipidemia

The anti-inflammatory activity of resveratrol in acute kidney injury: a systematic review and meta‐analysis of animal studies

Renal ameliorating effect of resveratrol in hydrogen peroxide induced male rats

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