Effects of resveratrol on female reproduction: A review

Abstract

The present review summarizes the current knowledge concerning physiological effects of resveratrol (RSV) with emphasis on the RSV action on female reproductive processes. The review outlines provenance, properties, mechanisms of action, physiological and therapeutic actions of RSV on female reproduction and other physiological processes, as well as areas of possible application of R. This review is based on the search for the related full papers indexed in Medline/Pubmed, Web of Science and SCOPUS databases between the year 2000 and 2021 according to the criteria of preferred reporting items for systematic reviews and meta‐analyses extension for scoping reviews and other related guidelines. The analysis of the available information suggests that RSV has a number of properties which enable its influence on various physiological processes including female reproduction at various regulatory levels via various extra‐ and intracellular signalling pathways. Despite some contradictions and limitations in the available data, they indicate applicability of both stimulatory and inhibitory effects of RSV for control and influence of various reproductive and non‐reproductive processes and treatment of their disorders in phytotherapy, animal production, medicine, biotechnology and assisted reproduction. To establish the clinical efficacy of RSV, further high quality studies are needed.

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?

“…Therefore, resveratrol levels may be translated, via SIRT1, into the development of inflammation, regulation of apoptosis, mitochondrial function, and protection from oxidative stress. Among other reasons, sirtuin has become a therapeutic target in reproductive system diseases [ 28 ]. Mitochondrial activity, as well as the efficiency of the organization of cell organelles, is one of the keys to achieving good-quality oocytes.…”

Natural Kinase Inhibitors for the Treatment and Management of Endometrial/Uterine Cancer: Preclinical to Clinical Studies

“…Resveratrol has stilbenoid chemistry which is produced by more than 70 species of plants in response to stress, injury, infection, or ultraviolet radiations ( Sirotkin, 2021 ). Resveratrol was found to have an apoptotic induction in uterine cancer cells.…”

Resveratrol Reverses Endothelial Colony-Forming Cell Dysfunction in Adulthood in a Rat Model of Intrauterine Growth Restriction

“…In females, resveratrol is considered a natural phytoestrogen since its chemical structure is similar to that of some estrogens, such as diethylstilbestrol. Although some publications have shown a negative influence of resveratrol on female reproductive processes [23], several studies have demonstrated beneficial effects of resveratrol. It has been shown to promote ovarian cell culture, in vitro fertilization of oocytes, ovarian stimulation, ovarian follicular growth and oocyte maturation, embryonic development, cryopreservation of oocytes and embryos, and it can improve the quality of oocytes obtained from aged females [24][25][26].…”