Effects of resveratrol on eNOS in the endothelium and the perivascular adipose tissue

Xia, Ning; Förstermann, Ulrich; Li, Huige

doi:10.1111/nyas.13397

Cited by 34 publications

(31 citation statements)

References 99 publications

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“…RE can also modulate NO release, which is crucial for endothelial function [123]. ROS decreases NO production and bioavailability [124], while RE increases them [125,126].…”

Section: Resveratrol Cytotoxic Mechanisms Can Induce Oxidative Stressmentioning

confidence: 99%

Potential Adverse Effects of Resveratrol: A Literature Review

Shaito

Posadino

Younes

et al. 2020

IJMS

403

293

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Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clinical trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects.In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.

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“…RE can also modulate NO release, which is crucial for endothelial function [123]. ROS decreases NO production and bioavailability [124], while RE increases them [125,126].…”

Section: Resveratrol Cytotoxic Mechanisms Can Induce Oxidative Stressmentioning

confidence: 99%

Potential Adverse Effects of Resveratrol: A Literature Review

Shaito

Posadino

Younes

et al. 2020

IJMS

403

293

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“…However, mounting evidence suggests that in disease states, PVAT contributes to endothelial dysfunction, neointimal formation, atherosclerosis, and other cardiovascular diseases, including abdominal aortic aneurysms, aortic stiffness, and vasculitis [4–12]. Mechanistically, these effects have been linked to local inflammation, oxidative stress, and decreased nitric oxide (NO) release from endothelium along with uncoupling of endothelial NO synthase (eNOS) in PVAT [13, 14]. …”

Section: Introductionmentioning

confidence: 99%

Remote Effects of Transplanted Perivascular Adipose Tissue on Endothelial Function and Atherosclerosis

Horimatsu

Patel

Prasad

et al. 2018

Cardiovasc Drugs Ther

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Purpose Perivascular adipose tissue (PVAT) surrounds the arterial adventitia and plays an important role in vascular homeostasis. PVAT expands in obesity, and inflamed PVAT can locally promote endothelial dysfunction and atherosclerosis. Here, using adipose tissue transplantation, we tested the hypothesis that expansion of PVAT can also remotely exacerbate vascular disease. Methods Fifty milligrams of abdominal aortic PVAT was isolated from high-fat diet (HFD)-fed wild-type mice and transplanted onto the abdominal aorta of lean LDL receptor knockout mice. Subcutaneous and visceral adipose tissues were used as controls. After HFD feeding for 10 weeks, body weight, glucose/insulin sensitivity, and lipid levels were measured. Adipocytokine gene expression was assessed in the transplanted adipose tissues, and the thoracic aorta was harvested to quantify atherosclerotic lesions by Oil-Red O staining and to assess vasorelaxation by wire myography. Results PVAT transplantation did not influence body weight, fat composition, lipid levels, or glucose/insulin sensitivity. However, as compared with controls, transplantation of PVAT onto the abdominal aorta increased thoracic aortic atherosclerosis. Furthermore, PVAT transplantation onto the abdominal aorta inhibited endothelium-dependent relaxation in the thoracic aorta. MCP-1 and TNF-α expression was elevated, while adiponectin expression was reduced, in the transplanted PVAT tissue, suggesting augmented inflammation as a potential mechanism for the remote vascular effects of transplanted PVAT. Conclusions These data suggest that PVAT expansion and inflammation in obesity can remotely induce endothelial dysfunction and augment atherosclerosis. Identifying the underlying mechanisms may lead to novel approaches for risk assessment and treatment of obesity-related vascular disease.

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“…Recently, both gene and protein expression of eNOS have been detected in adipose tissues [ 267 , 268 ], while eNOS in PVAT contributes to vascular NO production [ 269 , 270 , 271 ]. eNOS is abundantly found in both isolated brown adipocytes and BAT [ 272 ], while eNOS-derived NO can promote adiponectin synthesis and mitochondrial biogenesis [ 273 ].…”

Section: Oxidative Stress and Circadian Rhythmmentioning

confidence: 99%

Circadian Rhythm in Adipose Tissue: Novel Antioxidant Target for Metabolic and Cardiovascular Diseases

Man¹,

Xia²,

Li³

2020

Antioxidants

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Obesity is a major risk factor for most metabolic and cardiovascular disorders. Adipose tissue is an important endocrine organ that modulates metabolic and cardiovascular health by secreting signaling molecules. Oxidative stress is a common mechanism associated with metabolic and cardiovascular complications including obesity, type 2 diabetes, and hypertension. Oxidative stress can cause adipose tissue dysfunction. Accumulating data from both humans and experimental animal models suggest that adipose tissue function and oxidative stress have an innate connection with the intrinsic biological clock. Circadian clock orchestrates biological processes in adjusting to daily environmental changes according to internal or external cues. Recent studies have identified the genes and molecular pathways exhibiting circadian expression patterns in adipose tissue. Disruption of the circadian rhythmicity has been suggested to augment oxidative stress and aberrate adipose tissue function and metabolism. Therefore, circadian machinery in the adipose tissue may be a novel therapeutic target for the prevention and treatment of metabolic and cardiovascular diseases. In this review, we summarize recent findings on circadian rhythm and oxidative stress in adipose tissue, dissect the key components that play a role in regulating the clock rhythm, oxidative stress and adipose tissue function, and discuss the potential use of antioxidant treatment on metabolic and cardiovascular diseases by targeting the adipose clock.

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Effects of resveratrol on eNOS in the endothelium and the perivascular adipose tissue

Cited by 34 publications

References 99 publications

Potential Adverse Effects of Resveratrol: A Literature Review

Potential Adverse Effects of Resveratrol: A Literature Review

Remote Effects of Transplanted Perivascular Adipose Tissue on Endothelial Function and Atherosclerosis

Circadian Rhythm in Adipose Tissue: Novel Antioxidant Target for Metabolic and Cardiovascular Diseases

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