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“…8 ' Kimishima, et al 88 found a lowered seizure threshold in rabbits after cisternal NE injection. The alterations in EEG and cortical evoked potentials during NE perfusions provide further evidence that exogenous NE in the cortical extracellular space can disrupt neuronal function.…”
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“…8 ' Kimishima, et al 88 found a lowered seizure threshold in rabbits after cisternal NE injection. The alterations in EEG and cortical evoked potentials during NE perfusions provide further evidence that exogenous NE in the cortical extracellular space can disrupt neuronal function.…”
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“…Until the present investigation, the possible relationship of 5-HT to the pathophysiology of cerebrovascular disease has been largely concerned with the occurrence of vasospasm after subarachnoid haemorrhage and of vascular changes associated with cerebral trauma (Echlin, 1965;Brawley, Strandness, and Kelly, 1968;Simeone, Ryan, and Cotter, 1968;Arutiunov, Baron, and Majorova, 1970;Wilkins and Odom, 1970). In addition to its vasoconstrictor action, 5-HT depresses the reticular formation, cardiorespiratory centres and the cerebral cortex, and causes cerebral oedema (Marrazzi and Hart, 1955;Gaddum and Vogt, 1956;Bulle, 1957;Costa and Rinaldi, 1958;Monnier, 1960; 1 Supported by Grant No. NS 09287-01 from the National Institute of Neurological Diseases and Stroke.…”
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“…The finding of Brodie and coworkers that reserpine causes almost complete elimination of serotonin and epinephrine (4), and our finding that chlorpromazine enhances the central nervous system depressant effect of both these neurohumors (6,7), seem to indicate that these two ataractics cause tranquilization through their influence upon the neurohumors, but by opposite actions. This fact also seems to be supported by the findings of Brodie and others (3).…”
Section: Remarks On Possible Interaction Between Ataractics and Neuro...mentioning