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Cited by 32 publications
(22 citation statements)
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“…Our pre-defined study design stipulated that quantitative assessment would only be carried out on >10 observations leaving only focal cerebral ischemia studies. These 17 publications, [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] contained 52 comparisons: 30…”
Section: Resultsmentioning
confidence: 99%
“…Our pre-defined study design stipulated that quantitative assessment would only be carried out on >10 observations leaving only focal cerebral ischemia studies. These 17 publications, [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] contained 52 comparisons: 30…”
Section: Resultsmentioning
confidence: 99%
“…mTORC1 can serve as a regulator of autophagy and is highly sensitive to rapamycin ( 45 ). Although the role of mTOR in ischemic injury is unclear, mTOR has been previous demonstrated to exhibit neuroprotective properties ( 46 , 47 ). In focal cerebral IR models of neonatal rats, 3-MA exerted neuroprotective effects even after 4 h ischemia ( 48 ).…”
Section: Discussionmentioning
confidence: 99%
“…Wnt signaling pathway has been shown to play a role in the development and maintenance of the BBB, while mTOR signaling pathway is a therapeutic target of brain metastases and cerebral ischemia-reperfusion injury. [52][53][54] PcdhgC3 has been proposed to have tumor suppressor capabilities in human colorectal cancer. 55 Changes in Wnt and mTOR pathway due to downregulation of Pcdhg have been demonstrated in colorectal cancer cell lines and in Wilms' tumors.…”
Section: Discussionmentioning
confidence: 99%