Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study

Enseleit, Frank; Sudano, Isabella; Périat, Daniel; Winnik, Stephan; Wolfrum, Mathias; Flammer, Andreas J.; Fröhlich, Georg; Kaiser, Priska; Hirt, Astrid; Haile, Sarah R.; Krasniqi, Nazmi; Matter, Christian M.; Uhlenhut, Klaus; Högger, Petra; Neidhart, Michel; Lüscher, Thomas F.; Ruschitzka, Frank; Noll, Georg

doi:10.1093/eurheartj/ehr482

Cited by 80 publications

(132 citation statements)

References 45 publications

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“…PYC can noticeably reduce many of the risk factors associated with cardiovascular disease (CVD), such as systolic blood pressure, glycosylated hemoglobin, hyperlipidemia, and platelet aggregation (Parveen et al, 2009). PYC also improves endothelial function in patients with coronary artery disease by reducing oxidative stress (Enseleit et al, 2012). Enzogenol has been shown to block early atherogenesis and may therefore be useful for treating atherosclerosis (Kim et al, 2010).…”

Section: Organ Protective Effects Of Pbe Cardiovascular Protectionmentioning

confidence: 99%

Pine Bark Extracts: Nutraceutical, Pharmacological, and Toxicological Evaluation

Jiao

Zhang

et al. 2015

J Pharmacol Exp Ther

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Proanthocyanidins are among the most abundant constituents in pine bark extracts (PBEs). This review summarizes medical research on PBEs from Pinus pinaster, Pinus radiata, Pinus massoniana, and other less well characterized species. The precise mechanisms of the important physiologic functions of PBE components remain to be elucidated, but there is evidently great potential for the identification and development of novel antioxidant, anti-inflammatory, cardiovascular, neuroprotective, and anticancer medicines. Although toxicological data for PBEs are limited, no serious adverse effects have been reported. PBEs, therefore, may have potential as nutraceuticals and pharmaceuticals and should be safe for use as food ingredients.

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Section: Organ Protective Effects Of Pbe Cardiovascular Protectionmentioning

confidence: 99%

Pine Bark Extracts: Nutraceutical, Pharmacological, and Toxicological Evaluation

Jiao

Zhang

et al. 2015

J Pharmacol Exp Ther

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“…et al investigated the big ET-1 levels in a young population and found that the plasma big ET-1 levels were significantly higher in the patients with CAD than that without 27) . Several other studies have focused on the impact of currently available medications on the endothelial function in patients with stable CAD using the ET-1 level as a marker, but most of these studies included a small sample size, and no data are currently available regarding the relationship between ET-1 and the severity of CAD [28][29][30] . In addition, The plasma ET-1, who has a short half-life, does not reflect the true ET-1 value.…”

Section: Auc=064mentioning

confidence: 99%

Plasma Big Endothelin-1 Level and the Severity of New-onset Stable Coronary Artery Disease

Chen

Guo

et al. 2015

J Atheroscler Thromb

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“…All the ABPM measurements were performed using a validated device (Tracker NIBP2, Delmar, Del Mar Reynolds Medical, Hertford, UK). [30] In these previous studies approved by our institutional ethical committee all patients have granted their informed consent [28,29]. For this retrospective analysis pseudonymised data of these two previous pharmaceutical studies were used.…”

Section: Methodsmentioning

confidence: 99%

“…In our previous studies [28,29] we used ABPM to assess changes in blood pressure with drugs or food additives with uncertain effects on blood pressure. Here we used these datasets to study the reproducibility of ABPM.…”

Section: Original Articlementioning

confidence: 99%

Reproducibility of ambulatory blood pressure measurement in patients with coronary heart disease

2014

Cardiovasc Med

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SummaryAmbulatory blood pressure monitoring (ABPM) is a useful tool to establish the diagnosis of hypertension as well as for the monitoring of the response to antihypertensive therapy. We aimed to assess the reproducibility of the circadian blood pressure (BP) pattern (24 h, daytime and night-time BP and heart rate HR), the categorisation of individuals as dippers and non-dippers and the morning BP peak in three consecutive ABPM recordings obtained in patients with coronary artery disease.Methods: We performed a retrospective analysis of the reproducibility of 3 repeated ABPM obtained in 49 patients with coronary artery disease (age: 61.4 ± 7.9 years, 41 males, 36 hypertensives) enrolled in two previous studies using Tracker NIBP2 devices (Delmar, Del Mar Reynolds Medical, Hertford, UK). The standard interval of measurement was 20 minutes during the day and 45 minutes at night. The patients underwent ABPM on three separate days at intervals two to six weeks apart, on a typical week day with normal daily activity. All patients had a history of coronary artery disease and stable cardiovascular medication during the period of the three measurements.Results: Using analysis of variance for repeated measurement (ANOVA, Pillai's trace test) and by Pearson's correlation coefficient there was no significant variance in 24-hour, day and night BP and HR as well as morning BP peak. The categorisation of the subjects as dippers and non-dippers was also highly reproducible (p = 0.852; ns).Conclusions: Our data confirm that in patients with coronary artery disease the 24-hour recording of the circadian blood pressure patterns using Tracker NIBP2 devices is highly reproducible.

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Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study

Abstract: This study provides the first evidence that the antioxidant Pycnogenol improves endothelial function in patients with CAD by reducing oxidative stress.

Cited by 80 publications

References 45 publications

Pine Bark Extracts: Nutraceutical, Pharmacological, and Toxicological Evaluation

Pine Bark Extracts: Nutraceutical, Pharmacological, and Toxicological Evaluation

Plasma Big Endothelin-1 Level and the Severity of New-onset Stable Coronary Artery Disease

Reproducibility of ambulatory blood pressure measurement in patients with coronary heart disease

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