1992
DOI: 10.1055/s-2007-1020178
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Abstract: In a prospective randomized study with 80 male patients scheduled for aorto-coronary bypass grafting we investigated the influence of pulsatile and nonpulsatile perfusion mode on cell count (leukocytes, platelets, hematocrit), concentrations of thromboxane (TXB2), 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), plasma hemoglobin, PMN-elastase, complement C3a, clotting factor XII, lactate, plasmatic inhibitors (C1-INH, AT-III, alpha 2-antiplasmin), arterio-venous oxygen difference (AVDO2) and hemodynamic par… Show more

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Cited by 32 publications
(13 citation statements)
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“…However, no investigation has demonstrated a causal relationship between any one of these mechanisms and tPA-release during CPB. Finally, PMN elastase, an intracellular enzyme of known fibrinolytic potential [26], was shown to be elevated during CPB [27]. Thus, the liberation of cytokines and other intracellular compounds such as human T-cell serin proteinase 1 (HuTSP1), an activator of scuPA [28], can be assumed.…”
Section: Discussionmentioning
confidence: 99%
“…However, no investigation has demonstrated a causal relationship between any one of these mechanisms and tPA-release during CPB. Finally, PMN elastase, an intracellular enzyme of known fibrinolytic potential [26], was shown to be elevated during CPB [27]. Thus, the liberation of cytokines and other intracellular compounds such as human T-cell serin proteinase 1 (HuTSP1), an activator of scuPA [28], can be assumed.…”
Section: Discussionmentioning
confidence: 99%
“…In this regard it has to be mentioned that the extent as well as the time course of the activation of bi01ogical systems during CPB depend on the set-up, i.e. type of oxygenator [23,24] and bloodpump [25], and the perioperative management, i.e. hypothermia [26,27], anticoagulation and pump-flow [28].…”
Section: Discussionmentioning
confidence: 99%
“…Despite controversy, blood pulsation has been accepted to have a benefit during cardiopulmonary bypass, because it achieves greater perfusion to peripheral vessels and end-organs (Dapper et al, 1992, Orime et al, 1999. Furthermore, blood pulsation in a pediatric CRRT 1 animal model was found to deliver adequate performance over a 2-hour period in terms of ultrafiltration rates and cross-filter blood pressure drops (Lopez-Herce et al, 2006, Ruperez et al, 2003.…”
Section: Pulse Push/pull Hemodialysis (Ppphd)mentioning
confidence: 99%