Effects of progesterone on gastric emptying and intestinal transit in male rats

Liu, Chuanyong; Chen, Lian-Bi; Liu, Peiyi; Xie, Dacheng; Wang, Paulus S.

doi:10.3748/wjg.v8.i2.338

Cited by 51 publications

(42 citation statements)

References 49 publications

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“…This study also demonstrated that E 2 and a combination of E 2 and progesterone inhibit gastric emptying, but progesterone alone enhances gastric emptying in Ovx rats (Chen et al 1995). Furthermore, in male rats, low-dose progesterone has been reported to increase gastric emptying, while high-dose progesterone inhibits it (Liu et al 2002). In this study, increased gastric emptying was seen in Ovx rats, as secretion of E 2 and progesterone was blocked due to ovariectomy.…”

Section: Discussionsupporting

confidence: 65%

Human chorionic gonadotropin regulates gastric emptying in ovariectomized rats

Seow¹,

Lee²,

Doong³

et al. 2012

Journal of Endocrinology

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Prolongation of gastrointestinal transit resulting in nausea and vomiting in pregnancy (NVP) is the most common phenomenon during the first trimester of pregnancy. Increased human chorionic gonadotropin (hCG) concentration during the first trimester is the most likely cause of NVP. The aim of this study was to investigate the effect of hCG on gastrointestinal transit and plasma concentrations of cholecystokinin (CCK) in ovariectomized (Ovx) rats. I.p. injection of hCG was used to evaluate the dose effect of hCG on gastrointestinal transit in Ovx rats. The CCK antagonist lorglumide was used to clarify the role of CCK in regulating gastrointestinal transit. Gastrointestinal transit was assessed 15 min after intragastric gavage of a mixture of 10% charcoal and Na 2 51 CrO 4 (0.5 mCi/ml). After i.p. administration of hCG, gastric emptying was inhibited in Ovx rats, but intestinal transit was not affected. Plasma CCK concentrations were increased in a dose-dependent manner after hCG treatment, and gastric emptying showed a significant negative correlation with CCK concentrations (PZ0.01, r 2 ZK0.5104). Peripheral administration (i.p.) of lorglumide, a selective CCK 1 receptor antagonist, attenuated the hCG-induced inhibition of gastric emptying in Ovx rats, whereas central administration via the i.c.v. route did not. hCG treatment of Ovx rats inhibits gastric emptying in a dose-dependent manner via a peripheral mechanism of CCK hypersecretion and activation of CCK 1 receptors. Journal of EndocrinologyResearch K-M SEOW, J-L LEE and others hCG and gastric emptying 216:3 307-314

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Section: Discussionsupporting

confidence: 65%

Human chorionic gonadotropin regulates gastric emptying in ovariectomized rats

Seow¹,

Lee²,

Doong³

et al. 2012

Journal of Endocrinology

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show abstract

“…Bu sonuç, bizim metil selüloz boşalmasında artmış mide boşalması ile uyum içindedir. Buna karşın, OT'nin sıçanlarda ip verilmesi (0.8 mg/kg, bizim çalışmamızla aynı dozda) besin değeri olmayan sıvı gıdanın boşalmasını, çalış-mamızdaki kanüllü sıçanlarda olduğu gibi, inhibe etmiştir (31). Benzer şekilde, OT'nin anestezi altındaki sıçanlarda vagusun dorsal motor çekirdeğine uygulanması (4 pmol) mide motilitesini inhibe etmiştir (32).…”

Section: Discussionunclassified

The Effect of Oxytocin on the Gastric Emptying Rate of Liquids: The Role of Oxytocin and CCK-2 Receptors

Kumral¹,

Novruzov²,

Turan³

et al. 2013

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“…Certains cas déjà décrits dans la littérature [6,7] ont lieu à la même période, d'autres plus tardivement à 33 SA ½ mais en lien avec une cause tumorale (adénocarci-nome du côlon droit) [8]. L'hypothèse d'un ralentissement de la motilité intestinale due à l'imprégnation hormonale progestéronique dès 12 SA est également à évoquer [9][10][11].…”

Section: Discussionunclassified