Effects of probiotic supplementation on systemic and intestinal oxidant–antioxidant events in splenectomized rats

Cevher, Şule Çoşkun; Balabanlı, Barbaros; Aslım, Belma

doi:10.1007/s00595-014-1035-9

Cited by 9 publications

(5 citation statements)

References 38 publications

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“…Transient ischemia as well as the subsequent hyperemia are associated with an increased accumulation of oxidatively active substances, such as free radicals (van Wijck et al 2012). The antioxidative properties of probiotics have generally been known for a long time (Coskun Cevher et al 2015;Pieniz et al 2015). Various factors are probably responsible for this feature, e.g., generation of radical scavenging substances and induction of radical depleting enzymes in host tissues (Wang et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Effects of Escherichia coli strain Nissle 1917 on exercise-induced disruption of gastrointestinal integrity

et al. 2020

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The aim of the current study was to investigate the effects of the probiotic Escherichia coli strain Nissle 1917 (EcN) on the exercise-induced disruption of gastrointestinal (GI) integrity and the associated release of damage and inflammatory markers. Methods After a pre-performance test, 19 untrained subjects (aged 18-35 years) passed two identical exhaustive treadmill exercise tests in an intensity corresponding to 60-80% VO 2max in a test-retest design. The exercise tests were separated by a time period of 4 weeks. During this period, all subjects ingested 5 ml of an EcN suspension daily. Serum samples were taken before, immediately following and 3 h after both exercise tests. They were analyzed for indicators of GI integrity (zonulin; claudin-3; LPS), various damage and redox markers (I-FABP, GOT; GPT; TBARS) and inflammatory parameters (hsCRP; leucocytes). GI complaints were evaluated by a questionnaire. Results The intake of EcN resulted in a significantly lower increase in I-FABP and TBARS after exercise (p < 0.05). In contrast, no effect of EcN supplementation was found for hsCRP and leucocyte numbers. Similarly, no differences were found for levels of zonulin and claudin-3. Exercise-associated GI complaints were not affected by the probiotic supplement. Conclusion The probiotic EcN reduced the exercise-associated increase in oxidative stress. This antioxidative mechanism probably leads to a reduction of GI epithelial damage after exhaustive exercise. The lack of EcN effects on other markers of GI permeability and systemic inflammation is most likely due to an inadequate exercise load, with rather small and insignificant exercise effects on these parameters.

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Section: Discussionmentioning

confidence: 99%

Effects of Escherichia coli strain Nissle 1917 on exercise-induced disruption of gastrointestinal integrity

et al. 2020

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“…bulgaricus play an important role in the splenectomized patients. They have an ability to increase antioxidants and decrease the lipid peroxidation (Coşkun Cevher et al, 2015). In Pagrus major , Lacticaseibacillus rhamnosus (formerly known as Lactobacillus rhamnosus ) and Lactobacillus delbrueckii subsp.…”

Section: Reactive Oxygen Speciesmentioning

confidence: 99%

Balancing reactive oxygen species generation by rebooting gut microbiota

Singh

Ahlawat

Mohan

et al. 2022

Journal of Applied Microbiology

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Reactive oxygen species (ROS; free radical form O 2 •− , superoxide radical; OH • , hydroxyl radical; ROO • , peroxyl; RO • , alkoxyl and non-radical form 1 O 2 , singlet oxygen; H 2 O 2 , hydrogen peroxide) are inevitable companions of aerobic life with crucial role in gut health. But, overwhelming production of ROS can cause serious damage to biomolecules. In this review, we have discussed several sources of ROS production that can be beneficial or dangerous to the human gut. Micro-organisms, organelles and enzymes play crucial role in ROS generation, where NOX1 is the main intestinal enzyme, which produce ROS in the intestine epithelial cells. Previous studies have reported that probiotics play significant role in gut homeostasis by checking the ROS generation, maintaining the antioxidant level, immune system and barrier protection. With current knowledge, we have critically analysed the available literature and presented the outcome in the form of bubble maps to suggest that the probiotics help in controlling the ROS-specific intestinal diseases, such as inflammatory bowel disease (IBD) and colon cancer. Finally, it has been concluded that rebooting of the gut microbiota with probiotics, postbiotics or faecal microbiota transplantation (FMT) can have crucial implications in the structuring of gut communities for the personalized management of the gastrointestinal (GI) diseases.

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“…Excessive NO represents a factor of oxidative injuries to many visceral organs (Beckman et al, 1990); it is unstable and readily converted into NO x (Soleimani et al, 2016), which makes NO x a useful index to evaluate the oxidative status of intestinal environment (Coskun Cevher et al, 2015). The effect of different treatments on the concentration of NO x in the feces is shown in Figure 6A.…”

Section: Concentrations Of No X and Scfa In Fecesmentioning

confidence: 99%

“…The oxidative stress can be relieved by the counteraction of defense system with ROS through neutralization with antioxidants (Wen et al, 2015). Functional dietary antioxidant ingredients originating from fermented foods play an important role in preventing occurrence of diseases associated with oxidative stress by directly inhibiting of lipid peroxidation, scavenging ROS, and regulating intestinal environment (Coskun Cevher et al, 2015). These dietary antioxidants mainly include bioactive peptides (Ohata et al, 2016), microbial enzymes, and metabolites (Mishra et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant status and gut microbiota change in an aging mouse model as influenced by exopolysaccharide produced by Lactobacillus plantarum YW11 isolated from Tibetan kefir

Zhang

Zhao

Jiang

et al. 2017

Journal of Dairy Science

117

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This study investigated the effect of exopolysaccharide (EPS) produced by Lactobacillus plantarum YW11 on the oxidative status and gut microbiota in an aging mouse model induced with d-galactose. The in vitro assay of the antioxidant activity of the EPS showed concentration-dependent (0.25-3.0 mg/mL) activities. At 3.0 mg/mL, the EPS reached the highest scavenging activities with half maximal inhibitory concentration values against hydroxyl radicals at 75.10% and 1.22 mg/mL, superoxide anion at 62.71% and 1.54 mg/mL, 2, 2-diphenyl-1-picrylhydrazyl at 35.11% and 0.63 mg/mL, and the maximal chelating rate on ferrous ion and the half-maximal chelating concentration of the EPS at 41.09% and 1.07 mg/mL, respectively. High doses of EPS (50 mg/kg per day) effectively relieved the oxidative stress in the aging mice with increased levels of glutathione peroxidase, superoxide dismutase, catalase, and total antioxidant capacity in mice serum by 21.55, 33.14, 61.09, and 38.18%, respectively, and decreased malondialdehyde level from 11.69 to 5.89 mmol/mL compared with those in the untreated aging mice model. The analysis of pyrosequencing sequence data from the gut microbiota revealed that the EPS could recover the microbiota diversity and phylotypes decreased or eliminated by the d-galactose treatment. The EPS could selectively decrease the abundance of Flexispira (37.5 fold), and increase the abundance of Blautia (36.5 fold) and Butyricicoccus (9.5 fold), which correspondingly decreased the content of nitrogen oxides to 9.87% and increased the content of short-chain fatty acids by 2.23 fold, thereby improving the oxidative and health conditions of the host intestinal tract. Further correlation analysis of core-microbiota variation induced by different treatments showed a strong correlation with oxidative phenotypes [catalase, goodness of prediction (Q) = 0.49; total antioxidant capacity, Q = 0.45; nitrogen oxides, Q = 0.67; short-chain fatty acids, Q = 0.55]. The fermented milk with L. plantarum YW11 containing EPS also showed favorable antioxidant and gut microbiota regulating activities. The present finding provided new insights into the functional mechanism of probiotics bioactivity.

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Effects of probiotic supplementation on systemic and intestinal oxidant–antioxidant events in splenectomized rats

Abstract: Together, these data suggest that. L. delbruckii subsp. bulgaricus supplementation is beneficial for decreasing lipid peroxidation and enhancing the antioxidant capacity of systemic and intestinal tissue in splenectomized rats.

Cited by 9 publications

References 38 publications

Effects of Escherichia coli strain Nissle 1917 on exercise-induced disruption of gastrointestinal integrity

Effects of Escherichia coli strain Nissle 1917 on exercise-induced disruption of gastrointestinal integrity

Balancing reactive oxygen species generation by rebooting gut microbiota

Antioxidant status and gut microbiota change in an aging mouse model as influenced by exopolysaccharide produced by Lactobacillus plantarum YW11 isolated from Tibetan kefir

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