Effects of Prenatal Lipopolysaccharide Exposure on Epithelial Development and Function in Newborn Rat Intestine

Giannone, Peter J.; Schanbacher, Brandon L; Bauer, John; Reber, Kristina M.

doi:10.1097/01.mpg.0000232572.56397.d6

Cited by 34 publications

(24 citation statements)

References 29 publications

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“…Recently prenatal inflammation, in the form of chorioamnionitis, has been shown to predispose infants to the development of NEC. We have shown that rat pups exposed to prenatal inflammation have decreased mucosal growth and intestinal barrier function as well as altered NO regulation (Giannone et al, 2006). These may all be contributory mechanisms to the development of NEC in infants born to mothers with chorioamnionitis and add further insight into possible inflammatory etiologies of this disease.…”

Section: Speculative Mechanisms: the Role Of Inflammation In Nec And Chdmentioning

confidence: 97%

Necrotizing enterocolitis in neonates with congenital heart disease

et al. 2008

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Section: Speculative Mechanisms: the Role Of Inflammation In Nec And Chdmentioning

confidence: 97%

Necrotizing enterocolitis in neonates with congenital heart disease

et al. 2008

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“…For example, maternal smoking during pregnancy may cause reno-vascular changes (28) and elevated blood pressure. (29)Maternal exposure to endotoxin can result in fetal brain damage in the sheep (30) or altered intestinal growth and barrier function in the rat (31).…”

Section: Research Is Emerging On Developmental Disruption By Environmmentioning

confidence: 99%

Meeting Report on the 3rd International Congress on Developmental Origins of Health and Disease (DOHaD)

et al. 2007

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Developmental origins of health and disease (DOHaD) focuses on the earliest stages of human development, and provides a novel paradigm to complement other strategies for lifelong prevention of common chronic health conditions. The 3 rd International Congress on DOHaD, held in 2005, retained the most popular features from the first two biannual Congresses, while adding a number of innovations, including increased emphasis on implications of DOHaD for the developing world; programs for trainees and young investigators; and new perspectives, including developmental plasticity, influences of social hierarchies, effects of prematurity, and populations in transition. Emerging areas of science included, first, the controversial role of infant weight gain in predicting adult obesity, diabetes, and cardiovascular disease. Second, in the era of epidemic obesity, paying attention to the over-nourished fetus is as important as investigating the growth retarded one. Third, environmental toxins appear to have abroad range of long-lasting effects on the developing human. Fourth, epigenetic mechanisms could unite several strands of human and animal observations, and explain how genetically identical individuals raised in similar postnatal environments can nonetheless develop widely differing phenotypes. Improving the environment to which an individual is exposed during development may be as important as any other public health effort to enhance population health world wide. held in Mumbai, India, and Brighton, UK, respectively. The name change from FOAD to DOHaD recognizes the broader scope of developmental cues, extending from the oocyte to the infant and beyond, and the concept that the early life environment has widespread consequences for later health. After the 2 nd FOAD Congress, the International Society for DOHaD was formed, with members extending from evolutionary biologists through all branches of the basic and clinical sciences to epidemiologists and public health scientists. The 3 rd International Congress was the first to be held under the auspices of the new society.The 3 rd Congress retained the most popular features from the first two Congresses, while adding a number of innovations, including 1) increased emphasis on implications of DOHaD for the developing world; 2) programs for trainees and young investigators; and 3) new perspectives, e.g., evolutionary biology, developmental plasticity, influences of social hierarchies, effects of prematurity, populations in transition, the toxic environment, approaches to data analysis, discussion of controversial areas and policy implications. The 625content was organized around four domains-exposures, outcomes, mechanisms, and interventions-woven in an integrated fashion throughout the program. The format included both plenary and parallel scientific sessions, with additional special sessions, dedicated poster sessions, and opportunities for interdisciplinary discussion.Hailing from over 50 countries, 691 delegates attended the Congress. This number represente...

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“…The association between reduced nephron number and the development of hypertension has been well documented by Giannone PJ et al [7]. It can be explained that prenatal exposure to zymosan might have affected the renal development and caused decreased glomerular number.…”

Section: Discussionmentioning

confidence: 85%

“…Antenatal insults, including infections and inflammation, have been implicated in alterations of development, leading to increased incidences and/or severities of diseases of later onset [7]. Maternal protein or calorie restriction, as well as exposure to glucocorticoids during pregnancy, programmed hypertension and a reduced glomerular (nephron) number in offspring [8][9][10][11][12] Zymosan, a component of yeast cell walls comprised mainly of β-glucan and mannan, is a specific ligand for TLR2/6 and is capable of inducing inflammation that mimics a non-bacterial inflammatory response [13].…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Inflammation Induced by Zymosan Results in Activation of Intrarenal Renin-Angiotensin System in Adult Offspring Rats

Hao

Zhang

et al. 2010

Inflammation

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Prenatal exposure to inflammation produces offspring that are hypertensive in adulthood. The present study was to explore the role of intrarenal renin-angiotensin (Ang) system in the development of hypertension programmed by prenatal exposure to zymosan. Pregnant rats were randomly divided into control group and zymosan group (n = 6). Rats in these two groups were administered intraperitoneally with 0.5 ml vehicle and 2.37 mg/kg zymosan, respectively, on the eighth, tenth, and 12th day during gestation. The results showed the glomerular number and creatinine clearance rate decreased significantly in offspring of zymosan-treated rats. The renal cortex renin mRNA expression, Ang II-positive cells in renal cortex, and Ang II expression in renal medulla increased significantly in offspring of zymosan-treated rats at 7, 16, and 25 weeks of age. The plasma renin activity and Ang II concentration were unchanged. In conclusion, prenatal exposure to zymosan resulted in the activation of intrarenal renin-Ang system in adult offspring rats.

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Effects of Prenatal Lipopolysaccharide Exposure on Epithelial Development and Function in Newborn Rat Intestine

Abstract: Maternal exposure to LPS during pregnancy alters intestinal growth and regulation of iNOS in the newborn rat intestine.

Cited by 34 publications

References 29 publications

Necrotizing enterocolitis in neonates with congenital heart disease

Necrotizing enterocolitis in neonates with congenital heart disease

Meeting Report on the 3rd International Congress on Developmental Origins of Health and Disease (DOHaD)

Prenatal Exposure to Inflammation Induced by Zymosan Results in Activation of Intrarenal Renin-Angiotensin System in Adult Offspring Rats

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