Effects of prenatal exposure to triclosan on the liver transcriptome in chicken embryos

Guo, Jiahua; Ito, Shohei; Nguyen, Hoa Thanh; Yamamoto, Keizô; Tanoue, Rumi; Kunisue, Tatsuya; Iwata, Hisato

doi:10.1016/j.taap.2018.03.026

Cited by 23 publications

(13 citation statements)

References 48 publications

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“…Protein levels of PPAR α downstream target, acyl-coenzyme A oxidase, were decreased in HepG2 cells but were increased in Hepa1c1c7, which also showed higher DNA synthesis and blunted apoptosis through transforming growth factor (TGF- β ). PPAR signaling was similarly identified as a target of TCS through genome-wide CRISPR-Cas9 screening in HepG2 cells [188], zebrafish [189], and Gallus gallus chicken embryos [190]. In the latter model, PPAR signaling members Cyp7a1 , fatty acid-binding protein 1 ( Fabp1 ), acyl-CoA synthetase long-chain family member 5 ( Acsl5 ), acyl-CoA oxidase 2 ( Acox2 ), and perilipin 1 ( Plin1 ) were upregulated, whereas angiopoietin-like 4 ( Angptl ) was downregulated.…”

Section: Cellular Signalingmentioning

confidence: 99%

Triclosan: An Update on Biochemical and Molecular Mechanisms

Alfhili

Lee

2019

Oxidative Medicine and Cellular Longevity

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Triclosan (TCS) is a synthetic, chlorinated phenolic antimicrobial agent commonly used in commercial and healthcare products. Items made with TCS include soaps, deodorants, shampoos, cosmetics, textiles, plastics, surgical sutures, and prosthetics. A wealth of information obtained from in vitro and in vivo studies has demonstrated the therapeutic effects of TCS, particularly against inflammatory skin conditions. Nevertheless, extensive investigations on the molecular aspects of TCS action have identified numerous adversaries associated with the disinfectant including oxidative injury and influence of physiological lifespan and longevity. This review presents a summary of the biochemical alterations pertaining to TCS exposure, with special emphasis on the diverse molecular pathways responsive to TCS that have been elucidated during the present decade.

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Section: Cellular Signalingmentioning

confidence: 99%

Triclosan: An Update on Biochemical and Molecular Mechanisms

Alfhili

Lee

2019

Oxidative Medicine and Cellular Longevity

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“…The most dominant constituent of the protective layer is the Cr 2 O 3 due to the higher affinity of Cr to oxygen in comparison to Co and Mo and the corrosion proceeds mainly by Co dissolution. [6,30,31] The investigation of the corroded samples by RBS-NRA and SEM-EDS confirmed that the corrosion preferentially occurred by Co dissolution in specific sites and in modified regions of limited thickness.…”

Section: B Influence Of the Nitriding Oxidizing And Double Treatment On The Corrosion Resistancementioning

confidence: 69%

“…The samples subjected to nitriding displayed improved corrosion resistance due to the presence of nitrogen as well as the enhanced thickness of the modified layers. [30] The highest corrosion resistance was exhibited by the CoCrMo + N + O sample combining nitriding and oxidizing and the formation of a protective Cr 2 O 3 oxide plus a thicker nitrogen-rich layer after the double treatment. As was revealed by RBS-NRA investigation of this sample, the nitrogen depth distribution was little affected by the corrosion treatment in comparison to the nitrided sample.…”

Section: B Influence Of the Nitriding Oxidizing And Double Treatment On The Corrosion Resistancementioning

confidence: 94%

“…[21] Guo et al reported that N-implantation into CoCrMo induces a novel composite microstructure of the nanocrystalline CrN which enhances hardness, corrosion, and tribocorrosion properties and Ba et al found that plasma nitriding produces thicker, harder, and higher wear-resistant layers than the conventional CoCrMo alloys. [30,31] Therefore, nitriding can be beneficial in prosthesis applications depending on the combination of wear and corrosion processes induced by the chemical and tribological solicitations.…”

Section: Introductionmentioning

confidence: 99%

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The Influence of Plasma-Based Nitriding and Oxidizing Treatments on the Mechanical and Corrosion Properties of CoCrMo Biomedical Alloy

Noli

Pichon

Öztürk

2018

Metall Mater Trans A

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Plasma-based nitriding and/or oxidizing treatments were applied to CoCrMo alloy to improve its surface mechanical properties and corrosion resistance for biomedical applications. Three treatments were performed. A set of CoCrMo samples has been subjected to nitriding at moderate temperatures (~400°C). A second set of CoCrMo samples was oxidized at 395°C in pure O 2 . The last set of CoCrMo samples was nitrided and subsequently oxidized under the experimental conditions of previous sets (double treatment). The microstructure and morphology of the layers formed on the CoCrMo alloy were investigated by X-ray diffraction, Atomic Force Microscopy, and Scanning Electron Microscopy. In addition, nitrogen and oxygen profiles were determined by Glow Discharge Optical Emission Spectroscopy, Rutherford Backscattering Spectroscopy, Energy-Dispersive X-ray, and Nuclear Reaction Analysis. Significant improvement of the Vickers hardness of the CoCrMo samples after plasma nitriding was observed due to the supersaturated nitrogen solution and the formation of an expanded FCC c N phase and CrN precipitates. In the case of the oxidized samples, Vickers hardness improvement was minimal. The corrosion behavior of the samples was investigated in simulated body fluid (0.9 pct NaCl solution at 37°C) using electrochemical techniques (potentiodynamic polarization and cyclic voltammetry). The concentration of metal ions released from the CoCrMo surfaces was determined by Instrumental Neutron Activation Analysis. The experimental results clearly indicate that the CoCrMo surface subjected to the double surface treatment consisting in plasma nitriding and plasma oxidizing exhibited lower deterioration and better resistance to corrosion compared to the nitrided, oxidized, and untreated samples. This enhancement is believed to be due to the formation of a thicker and more stable layer.

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“…the amount of reactive oxygen species (ROS), the activity of SOD, CAT, and GST enzymes, the levels of lipid peroxidation (LPO) and DNA fragmentation) were performed on embryo liver because it is the main organ for detoxification and excretion of lipophilic chemicals and some studies demonstrated that TCS induced adverse effects on the liver of avian species (e.g. Guo et al, 2018). Biomarkers were not performed on the brain because measured TCS concentration was negligible (Table 1).…”

Section: Oxidative Stress and Genetic Biomarkersmentioning

confidence: 99%

Embryotoxic effects of in-ovo triclosan injection to the yellow-legged gull

et al. 2019

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Triclosan (TCS) is an antimicrobial agent used in diverse personal care products that is considered as an emerging contaminant of both aquatic and terrestrial ecosystems. Although TCS aquatic ecotoxicity is well known, information on the presence and effects on terrestrial organisms is still scarce. This study was aimed at exploring the embryotoxicity of TCS to the yellow-legged gull (Larus michahellis) induced by the in-ovo injection of 150 ng TCS/g egg weight. Effects of TCS on embryo morphological traits (i.e. body mass, tarsus length and head size). Moreover, oxidative and genetic effects were assessed in the embryo liver, by measuring the amount of reactive oxygen species (ROS), the activity of antioxidant (superoxide dismutase and catalase) and detoxifying (glutathione Stransferase-GST) enzymes, the levels of lipid peroxidation and DNA fragmentation. After the injection, the concentration of TCS measured in the yolk of unincubated eggs (159 ± 35 ng/g wet weight, ww) was close to the expected concentration. Triclosan was found in residual yolk (2.9 ± 1.1 ng/g ww), liver (2.3 ± 1.1 ng/g ww) and brain (0.2 ± 0.1 ng/g ww) of embryos soon before hatching. Triclosan did not significantly affect embryo morphological traits, while it increased ROS levels and promoted GST activity, inducing the onset of both oxidative and genetic damage. This study demonstrated, for the first time in a wild euriecious bird species with mixed habits, that TCS can be maternally transferred to developing embryos, representing a potential threat for offspring.

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Effects of prenatal exposure to triclosan on the liver transcriptome in chicken embryos

Cited by 23 publications

References 48 publications

Triclosan: An Update on Biochemical and Molecular Mechanisms

Triclosan: An Update on Biochemical and Molecular Mechanisms

The Influence of Plasma-Based Nitriding and Oxidizing Treatments on the Mechanical and Corrosion Properties of CoCrMo Biomedical Alloy

Embryotoxic effects of in-ovo triclosan injection to the yellow-legged gull

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