Effects of prenatal administration of acetylsalicylic acid in rats

Improvement of the evaluation method for teratogenicity using zebrafish embryos

“…In the present study, 4 teratogens (aspirin, indomethacin, for aspirin and indomethacin, no compound-related anomaly was found even when morphological assessment was conducted at sublethal dose (half of the 100% lethal dose) of each compound. External or skeletal anomalies were reported in mice for aspirin and indomethacin (Shapiro et al, 1976;Tuchmann-Duplessis et al, 1975;Kusayanagi et al, 1977) and some case reports have linked aspirin and indomethacin use with an increased risk of congenital anomalies, whereas others have not shown an association (Cook et al, 2003). Additionally, there was no evidence of any association between maternal aspirin ingestion in from the results of meta-analysis of aspirin (Kozer et al, 2002).…”

Improvement of the evaluation method for teratogenicity using zebrafish embryos

“…In the present study, 4 teratogens (aspirin, indomethacin, for aspirin and indomethacin, no compound-related anomaly was found even when morphological assessment was conducted at sublethal dose (half of the 100% lethal dose) of each compound. External or skeletal anomalies were reported in mice for aspirin and indomethacin (Shapiro et al, 1976;Tuchmann-Duplessis et al, 1975;Kusayanagi et al, 1977) and some case reports have linked aspirin and indomethacin use with an increased risk of congenital anomalies, whereas others have not shown an association (Cook et al, 2003). Additionally, there was no evidence of any association between maternal aspirin ingestion in from the results of meta-analysis of aspirin (Kozer et al, 2002).…”

Improvement of the evaluation method for teratogenicity using zebrafish embryos

“…In the present study, 4 teratogens (aspirin, indomethacin, for aspirin and indomethacin, no compound-related anomaly was found even when morphological assessment was conducted at sublethal dose (half of the 100% lethal dose) of each compound. External or skeletal anomalies were reported in mice for aspirin and indomethacin (Shapiro et al, 1976;Tuchmann-Duplessis et al, 1975;Kusayanagi et al, 1977) and some case reports have linked aspirin and indomethacin use with an increased risk of congenital anomalies, whereas others have not shown an association (Cook et al, 2003). Additionally, there was no evidence of any association between maternal aspirin ingestion in from the results of meta-analysis of aspirin (Kozer et al, 2002).…”

Improvement of the evaluation method for teratogenicity using zebrafish embryos

“…In the present study, 4 teratogens (aspirin, indomethacin, for aspirin and indomethacin, no compound-related anomaly was found even when morphological assessment was conducted at sublethal dose (half of the 100% lethal dose) of each compound. External or skeletal anomalies were reported in mice for aspirin and indomethacin (Shapiro et al, 1976;Tuchmann-Duplessis et al, 1975;Kusayanagi et al, 1977) and some case reports have linked aspirin and indomethacin use with an increased risk of congenital anomalies, whereas others have not shown an association (Cook et al, 2003). Additionally, there was no evidence of any association between maternal aspirin ingestion in from the results of meta-analysis of aspirin (Kozer et al, 2002).…”