Effects of postpartum treatment with oral calcium formate on serum calcium, serum metabolites, and the occurrence of diseases at the beginning of lactation of high-producing dairy cows

Ramella, Keli Daiane Cristina Libardi; Santos, Luis Gabriel Cucunubo; Patelli, Thais Helena Constantino; Flaiban, Karina Keller Marques da Costa; Lisbôa, Júlio Augusto Naylor

doi:10.1016/j.prevetmed.2020.105180

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…The results of Goff et al ( 15 ) showed that calcium propionate treatment had no significant effects on blood Ca of dairy cows but reduced the incidence of milk fever, which were similar to our results. Ramella et al ( 37 ) also discovered that oral treatment with calcium formate did not improve the serum Ca concentration of early lactation dairy cows.…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with calcium propionate could beneficially alter rectal microbial composition of early lactation dairy cows

et al. 2022

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Dietary supplementation with calcium propionate can effectively alleviate negative energy balance and hypocalcemia of dairy cows in early lactation. The objective of this study was to investigate the effects of calcium propionate feeding levels on the immune function, liver function, and fecal microbial composition of dairy cows in early lactation. Thirty-two multiparous Holstein cows were randomly assigned to four treatments after calving. Treatments were a basal diet plus 0, 200, 350, and 500 g calcium propionate per cow per day throughout a 5-week trial period. Cows were milked three times a day, and blood was sampled to measure immune function and liver function on d 7, 21, and 35. The rectal contents were sampled and collected on d 35 to analyze the microbial composition using 16S rRNA gene sequencing. The results indicated that increasing amounts of calcium propionate did not affected the serum concentrations of total protein, IgG, IgM, and calcium, but the concentrations of albumin and IgA changed quadratically. With the increase of calcium propionate, the activity of serum alanine transaminase and aspartate aminotransferase increased linearly, in contrast, the activity of alkaline phosphatase decreased linearly. Moreover, dietary supplementation with increasing levels of calcium propionate tended to quadratically decrease the relative abundance of Firmicutes while quadratically increased the abundance of Bacteroidetes, and consequently linearly decreased the Firmicutes/Bacteroidetes ratio in the rectal microbiota. Additionally, the supplementation of calcium propionate increased the relative abundances of Ruminococcaceae_UCG-005 and Prevotellaceae_UCG-004 linearly, and Ruminococcaceae_UCG-014 quadratically, but decreased the relative abundances of Lachnospiraceae_NK3A20_group and Family_XIII_AD3011_group quadratically. Compared with the CON group, the calcium propionate supplementation significantly decreased the relative abundance of Acetitomaculum but increased the abundances of Rikenellaceae_RC9_gut_group and Alistipes. In summary, these results suggested that the supplementation of calcium propionate to dairy cows in early lactation could beneficially alter the rectal microbiota.

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Section: Discussionmentioning

confidence: 99%

Dietary supplementation with calcium propionate could beneficially alter rectal microbial composition of early lactation dairy cows

et al. 2022

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Effects of oral calcium on reproduction and postpartum health in cattle: a meta-analysis and quality assessment

Ma,

Zhao

et al. 2024

Front. Vet. Sci.

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Postpartum blood calcium (Ca) concentration is related to the reproduction and health of cattle. Oral calcium supplements were given to dairy cows after calving to increase blood Ca concentration and reduce the risk of hypocalcemia. However, studies have shown that oral Ca has different effects in preventing disease. The purposes of this study were (i) to conduct a meta-analysis to evaluate the expected effect of oral Ca on incidence of calving-related diseases, pregnancy risk and milk yield in dairy cows, and (ii) to make a quality assessment of these related studies. In total, 22 eligible studies were included in this review. Meta-analysis showed that oral Ca could significantly reduce the incidence of hypocalcemia (clinical hypocalcemia: relative risk (RR) = 0.67, 95% confidence interval (CI) = [0.52, 0.87]; subclinical hypocalcemia: RR = 0.81, CI = [0.72, 0.91]), and incidence of retained placenta (RR = 0.77, CI = [0.62, 0.95]), improved blood Ca concentrations: mean difference (MD) = 0.08; 95% CI = [0.04, 0.11]. For other results, the meta-analysis revealed a lack of evidence of the correlation between oral Ca and serum magnesium (Mg) / phosphorus (P) concentration (Mg: MD = −0.04; 95% CI = [−0.10, 0.02]; P: MD = 0.05; 95% CI = [−0.10, 0.21]) or incidence of other calving-related disorders (metritis: RR = 1.06, CI = [0.94, 1.19]; ketosis: RR = 1.04, CI = [0.91, 1.18]; mastitis: RR = 1.02, CI = [0.86, 1.21]; displacement of the abomasum: RR = 0.81, CI = [0.57, 1.16]) or pregnancy risk (pregnancy risk at first service: RR = 0.99, CI = [0.94, 1.05]; overall pregnancy rate: RR = 1.03, CI = [0.98, 1.08]) or milk yield (MD = 0.44; 95% CI = [−0.24, 1.13]). The distribution of the funnel plot formed by the included studies was symmetrical, and the Egger’s test had a p > 0.05, indicating that there was no significant publication bias. Sensitivity analyses results suggested that the results of meta-analysis are robust. Quality assessment of the included studies revealed that the risk of bias was focused on selection bias, performance bias, detection bias and other sources of bias, and the future research should focus on these aspects.

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Effects of postpartum treatment with oral calcium formate on serum calcium, serum metabolites, and the occurrence of diseases at the beginning of lactation of high-producing dairy cows

Cited by 2 publications

References 27 publications

Dietary supplementation with calcium propionate could beneficially alter rectal microbial composition of early lactation dairy cows

Dietary supplementation with calcium propionate could beneficially alter rectal microbial composition of early lactation dairy cows

Effects of oral calcium on reproduction and postpartum health in cattle: a meta-analysis and quality assessment

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