Effects of Plasmin on Human Factor VIII (AHF)

Pasquini, Rossana; Hershgold, Edward J.

doi:10.1182/blood.v41.1.105.105

Cited by 45 publications

(5 citation statements)

References 4 publications

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“…Plasmin is a two‐chain macromolecule joined by two disulphide bridges (94,95) with a broad specificity protease (96–99), that cooperates with fibrin to form a clot. The role of plasmin in tumour cell invasion and migration is well documented (100–102), with evidences for both direct (by degrading proteins of the extracellular matrix and activating plasminogen activators) and indirect action (by activating of matrix metalloproteases).…”

Section: Inhibition Of Serine Proteases Activity By Polyphenolsmentioning

confidence: 99%

Natural Occurring Polyphenols as Template for Drug Design. Focus on Serine Proteases

et al. 2009

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Several major physio-pathological processes, including cancer, inflammatory states and thrombosis, are all strongly dependent upon the fine regulation of proteolytic enzyme activities, and dramatic are the consequences of unbalanced equilibria between enzymes and their cognate inhibitors. In this perspective, the discovery of small-molecule ligands able to modulate catalytic activities has a massive therapeutic potential and is a stimulating goal. Numerous recent experimental evidences revealed that proteolytic enzymes can be opportunely targeted, reporting on small ligands capable of binding to these biological macromolecules with drug-like potencies, and primarily with comparable (or even higher) efficiency with respect to their endogenous binding partner. In particular, natural occurring polyphenols and their derivatives recently disclosed these intriguing abilities, making them promising templates for drug design and development. In this review, we compared the inhibitory capacities of a set of monomeric polyphenols toward serine proteases activity, and finally summarized the data with an emphasis on the derivation of a pharmacophore model.

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Section: Inhibition Of Serine Proteases Activity By Polyphenolsmentioning

confidence: 99%

Natural Occurring Polyphenols as Template for Drug Design. Focus on Serine Proteases

et al. 2009

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“…Associated with VIII:C in plasma is a protein, so-called factor VIII related protein (16), which can be determined immunologically (VIII:R:AG, factor VIII related antigen). This protein resists proteolytic degradation better than VII1:C (13). A discrepancy between VII1:C and VII1:R:AG may thus indicate pathological proteolysis.…”

mentioning

confidence: 94%

Factor Viii Activity and Antigen in Sick Newborns With Pathological Proteolysis in Blood

Henriksson

Holmberg²

1978

Acta Paediatrica

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Factor VIII clotting activity (VII:C) and factor VIII related antigen (VIII:R:AG) were determined in 12 sick newborn infants with pathological proteolysis in their circulation. A marked discrepancy was noted between VIII:R:AG and VIII:C, the ratio in sick infants being, on average, 2:1, while no discrepancy was seen in healthy newborns. The finding in the sick infants resembled a low grade plasminogen activation, which was studied experimentally. It is concluded that demonstration of a marked discrepancy between VIII:R:AG and VIII:C is a useful indication of pathologic proteolysis in sick newborns.

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“…The AHF activity may be low in some acquired diseases, such as osteomyelo- Penick 1957, Donaldsen 1960, Pasquini & Hershgold 1973, which may thus be reduced in fibrinolytic states (NilChn 1962). The AHF activity may also be low in intravascular coagulation (Merskey 1969, Ratnoff 1969, Lasch et a1 1971, Colman et a1 1972.…”

mentioning

confidence: 99%

AHF Related Protein in Clinical Praxis

Holmberg¹,

Nilsson²

1974

Scandinavian Journal of Haematology

103

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Factor VIII (AHF) antigen and activity have been determined in 243 patients with various diseases. A rise of both antigen and activity was found in all groups. The correlation between antigen and activity was not good in some of the diseases, however. The reason is discussed. Factor VIII protein was isolated from one patient with necrosis of the liver and its properties were compared to those of normal factor VIII protein.

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Effects of Plasmin on Human Factor VIII (AHF)

Cited by 45 publications

References 4 publications

Natural Occurring Polyphenols as Template for Drug Design. Focus on Serine Proteases

Natural Occurring Polyphenols as Template for Drug Design. Focus on Serine Proteases

Factor Viii Activity and Antigen in Sick Newborns With Pathological Proteolysis in Blood

AHF Related Protein in Clinical Praxis

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