Effects of pindolol therapy on the size of experimentally induced myocardial infarction in the pig

Abstract

Summary: The effect of pindolol on experimental myocardial infarction was studied in a pig model. Intravenous application of 0.05 mg pindolol per kg body weight was initiated one hour after coronary ligation and repeated at 12-hour intervals for five days. No significant difference in infarct size could be found between pindolol-treated animals (20.4f0.6% SEM of whole ventricular mass, n=6) and untreated controls (20.5+1.2% SEM, n=9). Hemodynamic data did not change significantly throughout the experiment. These results differ in pa; from those reported by other investigators: The disagreement may be due to the specific pharmacological properties of the applied drug, to variations in the dosages of beta blockers, as well as to differences in the study design.

Conventional Pig as Animal Model for Human Renal Drug Excretion Processes: Unravelling the Porcine Renal Function by Use of a Cocktail of Exogenous Markers

“…Furthermore, the IV dose of 0.05 mg/kg that was used in the present study resulted in much lower plasma concentrations than an oral dosage of 5 or 15 mg of pindolol in humans, minimizing the risk of potential adverse renal effects (Gross et al, 2001;Udy et al, 2014). Furthermore, in pigs, in whom mycocardial infarction was induced, an equivalent IV dose of 0.05 mg/kg pindolol did not induce any hemodynamical changes (Friedli et al, 1986). To the authors' knowledge, information about the PK of pindolol in pigs is not available.…”

“…Due to the poor solubility of pindolol in water, the solution was slightly acidified with glacial acetic acid (0.04 v/v %) followed by sonication to enhance solubility (Fornal et al, 1999). The administered doses were determined based on available literature and practical considerations (Friedli et al, 1986;Gross et al, 2001;Gasthuys et al, 2017a). In the study of Gross et al, fluconazole and pindolol were both administered orally to humans (Gross et al, 2001).…”